HIC2

Details:

UniProt Entry: Q96JB3
Gene: HIC2
Class: RING
Family: RING6
Protein length: 615
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 7txc

Protein Sequence ▾

>Q96JB3
MVSGPLALRW CAWAGRGDMG PDMELPSHSK QLLLQLNQQR TKGFLCDVII MVENSIFRAH
KNVLAASSIY FKSLVLHDNL INLDTDMVSS TVFQQILDFI YTGKLLPSDQ PAEPNFSTLL
TAASYLQLPE LAALCRRKLK RAGKPFGSGR AGSTGMGRPP RSQRLSTASV IQARYQGLVD
GRKGAHAPQE LPQAKGSDDE LFLGGSNQDS VQGLGRAVCP AGGEAGLGGC SSSTNGSSGG
CEQELGLDLS KKSPPLPPAT PGPHLTPDDA AQLSDSQHGS PPAASAPPVA NSASYSELGG
TPDEPMDLEG AEDNHLSLLE APGGQPRKSL RHSTRKKEWG KKEPVAGSPF ERREAGPKGP
CPGEEGEGVG DRVPNGILAS GAGPSGPYGE PPYPCKEEEE NGKDASEDSA QSGSEGGSGH
ASAHYMYRQE GYETVSYGDN LYVCIPCAKG FPSSEQLNAH VETHTEEELF IKEEGAYETG
SGGAEEEAED LSAPSAAYTA EPRPFKCSVC EKTYKDPATL RQHEKTHWLT RPFPCNICGK
MFTQRGTMTR HMRSHLGLKP FACDECGMRF TRQYRLTEHM RVHSGEKPYE CQLCGGKFTQ
QRNLISHLRM HTSPS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
21	149	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
23	141	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
36	141	Domain	BTB/POZ domain	IPR000210	PF00651
46	143	Domain	BTB/POZ domain	IPR000210	SM00225
46	109	Domain	BTB/POZ domain	IPR000210	PS50097
438	470	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
442	469	Domain	Zinc finger C2H2-type	IPR013087	PS50157
442	464	Domain	Zinc finger C2H2-type	IPR013087	SM00355
444	464	Domain	Zinc finger C2H2-type	IPR013087	PS00028
503	555	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
505	532	Domain	Zinc finger C2H2-type	IPR013087	PS50157
505	527	Domain	Zinc finger C2H2-type	IPR013087	SM00355
507	527	Domain	Zinc finger C2H2-type	IPR013087	PS00028
533	555	Domain	Zinc finger C2H2-type	IPR013087	PF00096
533	560	Domain	Zinc finger C2H2-type	IPR013087	PS50157
533	555	Domain	Zinc finger C2H2-type	IPR013087	SM00355
535	555	Domain	Zinc finger C2H2-type	IPR013087	PS00028
541	598	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
561	583	Domain	Zinc finger C2H2-type	IPR013087	SM00355
561	588	Domain	Zinc finger C2H2-type	IPR013087	PS50157
561	583	Domain	Zinc finger C2H2-type	IPR013087	PF00096
563	583	Domain	Zinc finger C2H2-type	IPR013087	PS00028
589	615	Domain	Zinc finger C2H2-type	IPR013087	PS50157
589	611	Domain	Zinc finger C2H2-type	IPR013087	PF00096
589	611	Domain	Zinc finger C2H2-type	IPR013087	SM00355
591	611	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	NAS	PMID:11554746
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:12052894
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

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