THOC3

Details:

UniProt Entry: Q96J01
Gene: THOC3
Class: Other E3 Components
Family: Adaptor
Protein length: 351
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q96J01
MAVPAAAMGP SALGQSGPGS MAPWCSVSSG PSRYVLGMQE LFRGHSKTRE FLAHSAKVHS
VAWSCDGRRL ASGSFDKTAS VFLLEKDRLV KENNYRGHGD SVDQLCWHPS NPDLFVTASG
DKTIRIWDVR TTKCIATVNT KGENINICWS PDGQTIAVGN KDDVVTFIDA KTHRSKAEEQ
FKFEVNEISW NNDNNMFFLT NGNGCINILS YPELKPVQSI NAHPSNCICI KFDPMGKYFA
TGSADALVSL WDVDELVCVR CFSRLDWPVR TLSFSHDGKM LASASEDHFI DIAEVETGDK
LWEVQCESPT FTVAWHPKRP LLAFACDDKD GKYDSSREAG TVKLFGLPND S

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
23	347	Family	TREX component Tex1/THOC3	IPR040132	PTHR22839
39	179	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
44	83	Repeat	WD40 repeat	IPR001680	SM00320
47	329	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
48	81	Repeat	WD40 repeat	IPR001680	PF00400
51	92	Repeat	WD40 repeat	IPR001680	PS50082
70	84	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
88	128	Repeat	WD40 repeat	IPR001680	SM00320
94	128	Repeat	WD40 repeat	IPR001680	PF00400
95	137	Repeat	WD40 repeat	IPR001680	PS50082
115	129	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
131	169	Repeat	WD40 repeat	IPR001680	SM00320
134	243	Domain	Translation initiation factor, beta propellor-like domain	IPR013979	PF08662
180	349	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
213	252	Repeat	WD40 repeat	IPR001680	SM00320
220	254	Repeat	WD40 repeat	IPR001680	PS50082
239	253	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
255	294	Repeat	WD40 repeat	IPR001680	SM00320
266	315	Domain	Anaphase-promoting complex subunit 4, WD40 domain	IPR024977	PF12894
297	346	Repeat	WD40 repeat	IPR001680	SM00320

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006406	mRNA export from nucleus	Biological Process	IEA	GO_REF:0000002
GO:0006397	mRNA processing	Biological Process	IEA	GO_REF:0000043
GO:0008380	RNA splicing	Biological Process	IEA	GO_REF:0000043
GO:0051028	mRNA transport	Biological Process	IEA	GO_REF:0000043
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0000781	chromosome, telomeric region	Cellular Component	IDA	PMID:24270157
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-159101
GO:0016607	nuclear speck	Cellular Component	IEA	GO_REF:0000044
GO:0000346	transcription export complex	Cellular Component	IDA	PMID:15833825
GO:0000445	THO complex part of transcription export complex	Cellular Component	IBA	GO_REF:0000033
GO:0003723	RNA binding	Molecular Function	IEA	GO_REF:0000043

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