FXL20

Details:

UniProt Entry: Q96IG2
Gene: FBXL20
Class: Other E3 Components
Family: Receptor
Protein length: 436
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q96IG2
MRRDVNGVTK SRFEMFSNSD EAVINKKLPK ELLLRIFSFL DVVTLCRCAQ VSRAWNVLAL
DGSNWQRIDL FDFQRDIEGR VVENISKRCG GFLRKLSLRG CLGVGDNALR TFAQNCRNIE
VLNLNGCTKT TDATCTSLSK FCSKLRHLDL ASCTSITNMS LKALSEGCPL LEQLNISWCD
QVTKDGIQAL VRGCGGLKAL FLKGCTQLED EALKYIGAHC PELVTLNLQT CLQITDEGLI
TICRGCHKLQ SLCASGCSNI TDAILNALGQ NCPRLRILEV ARCSQLTDVG FTTLARNCHE
LEKMDLEECV QITDSTLIQL SIHCPRLQVL SLSHCELITD DGIRHLGNGA CAHDQLEVIE
LDNCPLITDA SLEHLKSCHS LERIELYDCQ QITRAGIKRL RTHLPNIKVH AYFAPVTPPP
SVGGSRQRFC RCCIIL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
18	264	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
22	68	Domain	F-box domain	IPR001810	PS50181
27	69	Domain	F-box domain	IPR001810	PF12937
28	68	Domain	F-box domain	IPR001810	SM00256
90	115	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
116	141	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
142	165	Repeat	Leucine-rich repeat	IPR001611	PF13516
142	167	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
168	193	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
168	191	Repeat	Leucine-rich repeat	IPR001611	PF13516
194	219	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
219	243	Repeat	Leucine-rich repeat	IPR001611	PF13516
220	245	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
246	271	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
272	297	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
296	432	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
298	323	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
323	346	Repeat	Leucine-rich repeat	IPR001611	PF13516
324	349	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
353	377	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
378	403	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0001662	behavioral fear response	Biological Process	IEA	GO_REF:0000107
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0099575	regulation of protein catabolic process at presynapse, modulating synaptic transmission	Biological Process	IEA	GO_REF:0000107
GO:2000300	regulation of synaptic vesicle exocytosis	Biological Process	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000107
GO:0098685	Schaffer collateral - CA1 synapse	Cellular Component	IEA	GO_REF:0000107
GO:0098978	glutamatergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0098793	presynapse	Cellular Component	IEA	GO_REF:0000108
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:27705803

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