RN185

Details:

UniProt Entry: Q96GF1
Gene: RNF185
Class: RING
Family: RING4
Protein length: 192
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q96GF1
MASKGPSASA SPENSSAGGP SGSSNGAGES GGQDSTFECN ICLDTAKDAV ISLCGHLFCW
PCLHQWLETR PNRQVCPVCK AGISRDKVIP LYGRGSTGQQ DPREKTPPRP QGQRPEPENR
GGFQGFGFGD GGFQMSFGIG AFPFGIFATA FNINDGRPPP AVPGTPQYVD EQFLSRLFLF
VALVIMFWLL IA

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
26	180	Family	E3 ubiquitin-protein ligase RNF5/RNF185-like	IPR045103	PTHR12313
27	93	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
39	79	Domain	Zinc finger, RING-type	IPR001841	SM00184
39	80	Domain	Zinc finger, RING-type	IPR001841	PS50089
54	63	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0140896	cGAS/STING signaling pathway	Biological Process	IDA	PMID:30842659
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0006914	autophagy	Biological Process	IEA	GO_REF:0000043
GO:0036503	ERAD pathway	Biological Process	IBA	GO_REF:0000033
GO:0044314	protein K27-linked ubiquitination	Biological Process	IDA	PMID:28273161
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000043
GO:0045089	positive regulation of innate immune response	Biological Process	IDA	PMID:28273161
GO:0051607	defense response to virus	Biological Process	IDA	PMID:28273161
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:24019521
GO:0055085	transmembrane transport	Biological Process	TAS	Reactome:R-HSA-382556
GO:0060340	positive regulation of type I interferon-mediated signaling pathway	Biological Process	IDA	PMID:28273161
GO:1904294	positive regulation of ERAD pathway	Biological Process	IMP	PMID:27485036
GO:1904380	endoplasmic reticulum mannose trimming	Biological Process	IEA	GO_REF:0000117
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0005739	mitochondrion	Cellular Component	IEA	GO_REF:0000043
GO:0005741	mitochondrial outer membrane	Cellular Component	IEA	GO_REF:0000120
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000120
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0044322	endoplasmic reticulum quality control compartment	Cellular Component	IEA	GO_REF:0000108
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:19549727
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0043130	ubiquitin binding	Molecular Function	IDA	PMID:27485036
GO:0044390	ubiquitin-like protein conjugating enzyme binding	Molecular Function	IBA	GO_REF:0000033
GO:0044877	protein-containing complex binding	Molecular Function	IPI	PMID:24019521
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


O75915	PRAF3	Yes	No	Yes	No	25416956	EBI-10189917	E3-specific
Q12981	SEC20	Yes	Yes	No	No	—	No	E3-specific
Q9BRJ7	TIRR	Yes	Yes	No	No	—	No	E3-specific

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Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
O75915	PRAF3	Yes	No	Yes	No	25416956	EBI-10189917	E3-specific
Q12981	SEC20	Yes	Yes	No	No	—	No	E3-specific
Q9BRJ7	TIRR	Yes	Yes	No	No	—	No	E3-specific