TRI11

Details:

UniProt Entry: Q96F44
Gene: TRIM11
Class: RING
Family: RING5
Protein length: 468
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 7qs1

Protein Sequence ▾

>Q96F44
MAAPDLSTNL QEEATCAICL DYFTDPVMTD CGHNFCRECI RRCWGQPEGP YACPECRELS
PQRNLRPNRP LAKMAEMARR LHPPSPVPQG VCPAHREPLA AFCGDELRLL CAACERSGEH
WAHRVRPLQD AAEDLKAKLE KSLEHLRKQM QDALLFQAQA DETCVLWQKM VESQRQNVLG
EFERLRRLLA EEEQQLLQRL EEEELEVLPR LREGAAHLGQ QSAHLAELIA ELEGRCQLPA
LGLLQDIKDA LRRVQDVKLQ PPEVVPMELR TVCRVPGLVE TLRRFRGDVT LDPDTANPEL
ILSEDRRSVQ RGDLRQALPD SPERFDPGPC VLGQERFTSG RHYWEVEVGD RTSWALGVCR
ENVNRKEKGE LSAGNGFWIL VFLGSYYNSS ERALAPLRDP PRRVGIFLDY EAGHLSFYSA
TDGSLLFIFP EIPFSGTLRP LFSPLSSSPT PMTICRPKGG SGDTLAPQ

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	80	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
16	57	Domain	Zinc finger, RING-type	IPR001841	PS50089
16	56	Domain	Zinc finger, RING-type	IPR001841	SM00184
31	40	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
87	128	Domain	B-box-type zinc finger	IPR000315	SM00336
87	128	Domain	B-box-type zinc finger	IPR000315	PS50119
89	128	Domain	B-box-type zinc finger	IPR000315	PF00643
268	461	Domain	B30.2/SPRY domain	IPR001870	PS50188
279	456	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
280	463	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
285	302	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
286	338	Domain	SPRY-associated	IPR006574	SM00589
289	337	Domain	SPRY-associated	IPR006574	PF13765
302	319	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
324	348	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
339	458	Domain	SPRY domain	IPR003877	SM00449
341	443	Domain	SPRY domain	IPR003877	PF00622
354	367	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
395	419	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
426	444	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0010468	regulation of gene expression	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0032897	negative regulation of viral transcription	Biological Process	IBA	GO_REF:0000033
GO:0044790	suppression of viral release by host	Biological Process	IBA	GO_REF:0000033
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000107
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:0046597	host-mediated suppression of symbiont invasion	Biological Process	IBA	GO_REF:0000033
GO:0046598	positive regulation of viral entry into host cell	Biological Process	IEA	GO_REF:0000120
GO:0050768	negative regulation of neurogenesis	Biological Process	IEA	GO_REF:0000107
GO:0051607	defense response to virus	Biological Process	IEA	GO_REF:0000043
GO:0051865	protein autoubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0140972	negative regulation of AIM2 inflammasome complex assembly	Biological Process	IDA	PMID:27498865
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:16904669
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019904	protein domain specific binding	Molecular Function	IEA	GO_REF:0000107
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IDA	PMID:27498865
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


Q16828	DUS6	Yes	No	No	No	—	No	E3-specific
P0CJ68	HMN1	Yes	No	No	No	—	No	E3-specific
P26367	PAX6	Yes	Yes	No	No	16098226	EBI-851832	E3-specific
Q96QS3	ARX	Yes	Yes	No	No	—	No	E3-specific
Q9P219	DAPLE	Yes	No	No	No	—	No	E3-specific
O60346	PHLP1	Yes	No	No	No	—	No	E3-specific
Q96RN5	MED15	Yes	Yes	No	No	16904669	EBI-8607298	E3-specific

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