RN125

Details:

UniProt Entry: Q96EQ8
Gene: RNF125
Class: RING
Family: RING4
Protein length: 232
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 5dka

Protein Sequence ▾

>Q96EQ8
MGSVLSTDSG KSAPASATAR ALERRRDPEL PVTSFDCAVC LEVLHQPVRT RCGHVFCRSC
IATSLKNNKW TCPYCRAYLP SEGVPATDVA KRMKSEYKNC AECDTLVCLS EMRAHIRTCQ
KYIDKYGPLQ ELEETAARCV CPFCQRELYE DSLLDHCITH HRSERRPVFC PLCRLIPDEN
PSSFSGSLIR HLQVSHTLFY DDFIDFNIIE EALIRRVLDR SLLEYVNHSN TT

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
33	128	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
37	76	Domain	Zinc finger, RING-type	IPR001841	PS50089
37	75	Domain	Zinc finger, RING-type	IPR001841	SM00184
52	61	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
94	126	Domain	Zinc finger C2HC RNF-type	IPR034734	PF18574
100	119	Domain	Zinc finger C2HC RNF-type	IPR034734	PS51803
140	196	Domain	Drought induced 19 protein type, zinc-binding domain	IPR008598	PF05605

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:1990830	cellular response to leukemia inhibitory factor	Biological Process	IEA	GO_REF:0000107
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0002250	adaptive immune response	Biological Process	IEA	GO_REF:0000043
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0032480	negative regulation of type I interferon production	Biological Process	IDA	PMID:17460044
GO:0039536	negative regulation of RIG-I signaling pathway	Biological Process	IDA	PMID:17460044
GO:0000139	Golgi membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000043
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0043231	intracellular membrane-bounded organelle	Cellular Component	IDA	PMID:17990982
GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	Cellular Component	IBA	GO_REF:0000033
GO:0002039	p53 binding	Molecular Function	IPI	PMID:25591766
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:17460044
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0031624	ubiquitin conjugating enzyme binding	Molecular Function	IPI	PMID:27411375
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q96EQ8	RN125	Yes	No	No	No	—	No	E3-specific
Q9HB29	ILRL2	Yes	No	No	No	—	No	E3-specific
P23458	JAK1	Yes	Yes	No	No	—	No	E3-specific
Q9BYX4	IFIH1	Yes	Yes	No	No	17460044	EBI-15633958	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q96EQ8	RN125	Yes	No	No	No	—	No	E3-specific
Q9HB29	ILRL2	Yes	No	No	No	—	No	E3-specific
P23458	JAK1	Yes	Yes	No	No	—	No	E3-specific
Q9BYX4	IFIH1	Yes	Yes	No	No	17460044	EBI-15633958	E3-specific