NEUL3

Details:

UniProt Entry: Q96EH8
Gene: NEURL3
Class: RING
Family: RING3
Protein length: 262
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q96EH8
MGAQLCFEAN AKAPREALRF HAEAKGAQVR LDTRGCIAHR RTTFHDGIVF SQRPVRLGER
VALRVLREES GWCGGLRVGF TRLDPACVSV PSLPPFLCPD LEEQSPTWAA VLPEGCALTG
DLVRFWVDRR GCLFAKVNAG CRLLLREGVP VGAPLWAVMD VYGTTKAIEL LDPTASRLPT
PMPWDLSNKA VPEPKATPGE ECAICFYHAA NTRLVPCGHT YFCRYCAWRV FSDTAKCPVC
RWQIEAVAPA QGPPALRVEE GS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
15	138	Domain	Neuralized homology repeat (NHR) domain	IPR006573	SM00588
17	173	Domain	Neuralized homology repeat (NHR) domain	IPR006573	PS51065
19	172	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
20	171	Domain	Neuralized homology repeat (NHR) domain	IPR006573	PF07177
178	244	Family	Neuralized	IPR037962	PTHR12429
187	249	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
202	240	Domain	Zinc finger, RING-type	IPR001841	SM00184
202	241	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000104
GO:0043409	negative regulation of MAPK cascade	Biological Process	ISS	GO_REF:0000024
GO:0070371	ERK1 and ERK2 cascade	Biological Process	IDA	PMID:16314496
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000043
GO:0070086	ubiquitin-dependent endocytosis	Biological Process	IBA	GO_REF:0000033
GO:1901800	positive regulation of proteasomal protein catabolic process	Biological Process	IDA	PMID:38667302
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005769	early endosome	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120

Enzyme–Substrate Interactions ▾

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