ZBT10

Details:

UniProt Entry: Q96DT7
Gene: ZBTB10
Class: RING
Family: RING6
Protein length: 871
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q96DT7
MSFSEMNRRT LAFRGGGLVT ASGGGSTNNN AGGEASAWPP QPQPRQPPPP APPALQPPNG
RGADEEVELE GLEPQDLEAS AGPAAGAAEE AKELLLPQDA GGPTSLGGGA GGPLLAERNR
RTLAFRGGGG GGLGNNGSSR GRPETSVWPL RHFNGRGPAT VDLELDALEG KELMQDGASL
SDSTEDEEEG ASLGDGSGAE GGSCSSSRRS GGDGGDEVEG SGVGAGEGET VQHFPLARPK
SLMQKLQCSF QTSWLKDFPW LRYSKDTGLM SCGWCQKTPA DGGSVDLPPV GHDELSRGTR
NYKKTLLLRH HVSTEHKLHE ANAQESEIPS EEGYCDFNSR PNENSYCYQL LRQLNEQRKK
GILCDVSIVV SGKIFKAHKN ILVAGSRFFK TLYCFSNKES PNQNNTTHLD IAAVQGFSVI
LDFLYSGNLV LTSQNAIEVM TVASYLQMSE VVQTCRNFIK DALNISIKSE APESVVVDYN
NRKPVNRDGL SSSRDQKIAS FWATRNLTNL ASNVKIENDG CNVDEGQIEN YQMNDSSWVQ
DGSPEMAENE SEGQTKVFIW NNMGSQGIQE TGKTRRKNQT TKRFIYNIPP NNETNLEDCS
VMQPPVAYPE ENTLLIKEEP DLDGALLSGP DGDRNVNANL LAEAGTSQDG GDAGTSHDFK
YGLMPGPSND FKYGLIPGTS NDFKYGLIPG ASNDFKYGLL PESWPKQETW ENGESSLIMN
KLKCPHCSYV AKYRRTLKRH LLIHTGVRSF SCDICGKLFT RREHVKRHSL VHKKDKKYKC
MVCKKIFMLA ASVGIRHGSR RYGVCVDCAD KSQPGGQEGV DQGQDTEFPR DEEYEENEVG
EADEELVDDG EDQNDPSRWD ESGEVCMSLD D

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
341	482	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
342	461	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
354	461	Domain	BTB/POZ domain	IPR000210	PF00651
364	433	Domain	BTB/POZ domain	IPR000210	PS50097
364	463	Domain	BTB/POZ domain	IPR000210	SM00225
722	749	Domain	Zinc finger C2H2-type	IPR013087	PS50157
722	744	Domain	Zinc finger C2H2-type	IPR013087	SM00355
734	787	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
750	772	Domain	Zinc finger C2H2-type	IPR013087	SM00355
750	777	Domain	Zinc finger C2H2-type	IPR013087	PS50157
752	772	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	ISS	GO_REF:0000024
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0000781	chromosome, telomeric region	Cellular Component	IDA	PMID:30629181
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Molecular Function	ISS	GO_REF:0000024
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	ISS	GO_REF:0000024
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0042162	telomeric DNA binding	Molecular Function	IDA	PMID:30629181

Enzyme–Substrate Interactions ▾

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