RN183

Details:

UniProt Entry: Q96D59
Gene: RNF183
Class: RING
Family: RING4
Protein length: 192
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q96D59
MAEQQGRELE AECPVCWNPF NNTFHTPKML DCCHSFCVEC LAHLSLVTPA RRRLLCPLCR
QPTVLASGQP VTDLPTDTAM LALLRLEPHH VILEGHQLCL KDQPKSRYFL RQPQVYTLDL
GPQPGGQTGP PPDTASATVS TPILIPSHHS LRECFRNPQF RIFAYLMAVI LSVTLLLIFS
IFWTKQFLWG VG

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	91	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
12	60	Domain	Zinc finger, RING-type	IPR001841	PF13639
13	59	Domain	Zinc finger, RING-type	IPR001841	SM00184
13	60	Domain	Zinc finger, RING-type	IPR001841	PS50089
32	41	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:26567849
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0034976	response to endoplasmic reticulum stress	Biological Process	IBA	GO_REF:0000033
GO:0051865	protein autoubiquitination	Biological Process	IEA	GO_REF:0000120
GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IBA	GO_REF:0000033
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000043
GO:0005765	lysosomal membrane	Cellular Component	ISS	GO_REF:0000024
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000120
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0033106	cis-Golgi network membrane	Cellular Component	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


P05026	AT1B1	Yes	Yes	No	No	—	No	E3-specific
O14763	TR10B	Yes	Yes	No	No	—	No	E3-specific

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P05026	AT1B1	Yes	Yes	No	No	—	No	E3-specific
O14763	TR10B	Yes	Yes	No	No	—	No	E3-specific