BIRC7

Details:

UniProt Entry: Q96CA5
Gene: BIRC7
Class: RING
Family: RING4
Protein length: 298
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 1oxn, 1oxq, 1oy7, 1tw6, 2i3h, 2i3i, 3f7g, 3f7h, 3f7i, 3gt9, 3gta, 3uw5, 4auq

Protein Sequence ▾

>Q96CA5
MGPKDSAKCL HRGPQPSHWA AGDGPTQERC GPRSLGSPVL GLDTCRAWDH VDGQILGQLR
PLTEEEEEEG AGATLSRGPA FPGMGSEELR LASFYDWPLT AEVPPELLAA AGFFHTGHQD
KVRCFFCYGG LQSWKRGDDP WTEHAKWFPS CQFLLRSKGR DFVHSVQETH SQLLGSWDPW
EEPEDAAPVA PSVPASGYPE LPTPRREVQS ESAQEPGGVS PAEAQRAWWV LEPPGARDVE
AQLRRLQEER TCKVCLDRAV SIVFVPCGHL VCAECAPGLQ LCPICRAPVR SRVRTFLS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
85	156	Repeat	BIR repeat	IPR001370	SM00238
87	154	Repeat	BIR repeat	IPR001370	PS01282
88	155	Repeat	BIR repeat	IPR001370	cd00022
90	154	Repeat	BIR repeat	IPR001370	PF00653
90	155	Repeat	BIR repeat	IPR001370	PS50143
234	298	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
252	285	Domain	Zinc finger, RING-type	IPR001841	SM00184
252	286	Domain	Zinc finger, RING-type	IPR001841	PS50089
267	276	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:1902531	regulation of intracellular signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0042981	regulation of apoptotic process	Biological Process	IEA	GO_REF:0000117
GO:0002088	lens development in camera-type eye	Biological Process	IEA	GO_REF:0000107
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IDA	PMID:16729033
GO:0031398	positive regulation of protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0042127	regulation of cell population proliferation	Biological Process	IDA	PMID:21617971
GO:0043066	negative regulation of apoptotic process	Biological Process	IBA	GO_REF:0000033
GO:0046330	positive regulation of JNK cascade	Biological Process	IEA	GO_REF:0000117
GO:0051726	regulation of cell cycle	Biological Process	IBA	GO_REF:0000033
GO:0070247	regulation of natural killer cell apoptotic process	Biological Process	IDA	PMID:18034418
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005813	centrosome	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000120
GO:0004869	cysteine-type endopeptidase inhibitor activity	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0030414	peptidase inhibitor activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:11024045
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019899	enzyme binding	Molecular Function	NAS	PMID:11801603
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	Molecular Function	IBA	GO_REF:0000033
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL5186855	ChEMBL	7.7	—	—	CC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O
E3 Binder	CHEMBL3039522	ChEMBL	9.0	GT6	—	CC[C@H](NC(=O)[C@H](C)NC)C(=O)N1C[C@@H](O)C[C@H]1Cc1c(-c2[nH]c3cc(F)ccc3c2C[C@@H]2C[C@H](O)CN2C(=O)[C@H](CC)NC(=O)[C@H](C)NC)[nH]c2cc(F)ccc12
E3 Binder	CHEMBL5175233	ChEMBL	7.3	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(S(=O)(=O)F)ccc1OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O
E3 Binder	CHEMBL5174454	ChEMBL	7.96	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(S(=O)(=O)F)ccc1OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H]1CCc2ccccc21
E3 Binder	CHEMBL5193194	ChEMBL	6.55	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(S(=O)(=O)F)ccc1OC)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O
E3 Binder	CHEMBL5170823	ChEMBL	6.32	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(S(=O)(=O)F)ccc1OC)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H]1CCc2ccccc21
E3 Binder	CHEMBL5195146	ChEMBL	6.56	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(S(=O)(=O)O)ccc1OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H]1CCc2ccccc21
E3 Binder	CHEMBL5181541	ChEMBL	7.46	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1ccc(S(=O)(=O)F)c(OC)c1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O
E3 Handle	CHEMBL2063869	ChEMBL	7.85	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)Nc1snnc1-c1ccccc1)C1CCCCC1
E3 Handle	CHEMBL2431768	ChEMBL	8.05	IUN	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2ccc(F)cc2)cs1)C1CCCCC1
E3 Binder	CHEMBL5169527	ChEMBL	6.06	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(S(=O)(=O)F)ccc1OC)C(=O)N1CCCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O
E3 Binder	CHEMBL5203019	ChEMBL	6.25	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(S(=O)(=O)F)ccc1OC)C(=O)N1CCCC[C@H]1C(=O)N[C@@H]1CCc2ccccc21
E3 Binder	CHEMBL5191180	ChEMBL	6.5	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(S(=O)(=O)F)ccc1OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H]1CCc2c(F)cccc21

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