RNF25

Details:

UniProt Entry: Q96BH1
Gene: RNF25
Class: RING
Family: RING9
Protein length: 459
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 2day, 2dmf, 5d1k, 5d1l, 5d1m

Protein Sequence ▾

>Q96BH1
MAASASAAAG EEDWVLPSEV EVLESIYLDE LQVIKGNGRT SPWEIYITLH PATAEDQDSQ
YVCFTLVLQV PAEYPHEVPQ ISIRNPRGLS DEQIHTILQV LGHVAKAGLG TAMLYELIEK
GKEILTDNNI PHGQCVICLY GFQEKEAFTK TPCYHYFHCH CLARYIQHME QELKAQGQEQ
EQERQHATTK QKAVGVQCPV CREPLVYDLA SLKAAPEPQQ PMELYQPSAE SLRQQEERKR
LYQRQQERGG IIDLEAERNR YFISLQQPPA PAEPESAVDV SKGSQPPSTL AAELSTSPAV
QSTLPPPLPV ATQHICEKIP GTRSNQQRLG ETQKAMLDPP KPSRGPWRQP ERRHPKGGEC
HAPKGTRDTQ ELPPPEGPLK EPMDLKPEPH SQGVEGPPQE KGPGSWQGPP PRRTRDCVRW
ERSKGRTPGS SYPRLPRGQG AYRPGTRRES LGLESKDGS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
9	444	Family	E3 ubiquitin-protein ligase RNF25	IPR039133	PTHR13198
16	130	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	G3DSA:3.10.110.10
16	125	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	SSF54495
18	128	Domain	RWD domain	IPR006575	SM00591
18	123	Domain	RWD domain	IPR006575	PF05773
18	128	Domain	RWD domain	IPR006575	PS50908
131	222	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
135	202	Domain	Zinc finger, RING-type	IPR001841	PS50089
135	201	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006414	translational elongation	Biological Process	IDA	PMID:36638793
GO:0006415	translational termination	Biological Process	IDA	PMID:27863242
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:36638793
GO:0085020	protein K6-linked ubiquitination	Biological Process	IDA	PMID:37951215
GO:0160127	protein-RNA covalent cross-linking repair	Biological Process	IDA	PMID:37951215
GO:0016567	protein ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process	IDA	PMID:12748188
GO:0072344	rescue of stalled ribosome	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0022626	cytosolic ribosome	Cellular Component	IDA	PMID:27863242
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	PMID:12748188
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000002
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:18757723
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0051059	NF-kappaB binding	Molecular Function	IPI	PMID:12748188

Enzyme–Substrate Interactions ▾


Q969F2	NKD2	Yes	Yes	Yes	No	18757723	EBI-15726331	E3-specific

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