NACC2

Details:

UniProt Entry: Q96BF6
Gene: NACC2
Class: Other E3 Components
Family: Adaptor
Protein length: 587
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q96BF6
MSQMLHIEIP NFGNTVLGCL NEQRLLGLYC DVSIVVKGQA FKAHRAVLAA SSLYFRDLFS
GNSKSAFELP GSVPPACFQQ ILSFCYTGRL TMTASEQLVV MYTAGFLQIQ HIVERGTDLM
FKVSSPHCDS QTAVIEDAGS EPQSPCNQLQ PAAAAAAPYV VSPSVPIPLL TRVKHEAMEL
PPAGPGLAPK RPLETGPRDG VAVAAGAAVA AGTAPLKLPR VSYYGVPSLA TLIPGIQQMP
YPQGERTSPG ASSLPTTDSP TSYHNEEDEE DDEAYDTMVE EQYGQMYIKA SGSYAVQEKP
EPVPLESRSC VLIRRDLVAL PASLISQIGY RCHPKLYSEG DPGEKLELVA GSGVYITRGQ
LMNCHLCAGV KHKVLLRRLL ATFFDRNTLA NSCGTGIRSS TSDPSRKPLD SRVLNAVKLY
CQNFAPSFKE SEMNVIAADM CTNARRVRKR WLPKIKSMLP EGVEMYRTVM GSAAASVPLD
PEFPPAAAQV FEQRIYAERR GDAATIVALR TDAVNVDLSA AANPAFDAGE EVDGAGSVIQ
EVAAPEPLPA DGQSPPQPFE QGGGGPSRPQ TPAAAARRPE GTYAGTL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	125	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
3	120	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
20	116	Domain	BTB/POZ domain	IPR000210	PF00651
30	124	Domain	BTB/POZ domain	IPR000210	SM00225
30	94	Domain	BTB/POZ domain	IPR000210	PS50097
351	448	Domain	BEN domain	IPR018379	PS51457
373	451	Domain	BEN domain	IPR018379	SM01025
375	432	Domain	BEN domain	IPR018379	PF10523

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IMP	PMID:22926524
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0008285	negative regulation of cell population proliferation	Biological Process	IDA	PMID:22926524
GO:0031503	protein-containing complex localization	Biological Process	IDA	PMID:22926524
GO:0042127	regulation of cell population proliferation	Biological Process	IEA	GO_REF:0000117
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	ISS	GO_REF:0000024
GO:0051260	protein homooligomerization	Biological Process	IDA	PMID:22926524
GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	Biological Process	IDA	PMID:22926524
GO:0000785	chromatin	Cellular Component	IDA	PMID:22926524
GO:0005634	nucleus	Cellular Component	ISS	GO_REF:0000024
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000052
GO:0005739	mitochondrion	Cellular Component	IDA	GO_REF:0000052
GO:0031981	nuclear lumen	Cellular Component	IEA	GO_REF:0000117
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IDA	PMID:22926524
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:22926524
GO:0042803	protein homodimerization activity	Molecular Function	IDA	PMID:22926524
GO:0042826	histone deacetylase binding	Molecular Function	IPI	PMID:22926524
GO:0044877	protein-containing complex binding	Molecular Function	IPI	PMID:22926524

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