TRI52

Details:

UniProt Entry: Q96A61
Gene: TRIM52
Class: RING
Family: RING5
Protein length: 297
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q96A61
MAGYATTPSP MQTLQEEAVC AICLDYFKDP VSISCGHNFC RGCVTQLWSK EDEEDQNEEE
DEWEEEEDEE AVGAMDGWDG SIREVLYRGN ADEELFQDQD DDELWLGDSG ITNWDNVDYM
WDEEEEEEEE DQDYYLGGLR PDLRIDVYRE EEILEAYDED EDEELYPDIH PPPSLPLPGQ
FTCPQCRKSF TRRSFRPNLQ LANMVQIIRQ MCPTPYRGNR SNDQGMCFKH QEALKLFCEV
DKEAICVVCR ESRSHKQHSV LPLEEVVQEY QEIKLETTLV GILQIEQESI HSKAYNQ

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
3	71	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
20	46	Domain	Zinc finger, RING-type	IPR001841	PS50089
20	186	Domain	Zinc finger, RING-type	IPR001841	SM00184
35	44	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
222	263	Domain	B-box-type zinc finger	IPR000315	PS50119
222	263	Domain	B-box-type zinc finger	IPR000315	SM00336
223	263	Domain	B-box-type zinc finger	IPR000315	PF00643

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0009967	positive regulation of signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0051607	defense response to virus	Biological Process	IEA	GO_REF:0000117
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:27667714
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:27667714
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000117
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000117
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:23077300

Enzyme–Substrate Interactions ▾


P35813	PPM1A	Yes	No	No	No	—	No	Cluster-specific
Q06124	PTN11	Yes	No	No	No	—	No	E3-specific

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P35813	PPM1A	Yes	No	No	No	—	No	Cluster-specific
Q06124	PTN11	Yes	No	No	No	—	No	E3-specific