MUL1

>Q969V5
MESGGRPSLC QFILLGTTSV VTAALYSVYR QKARVSQELK GAKKVHLGED LKSILSEAPG
KCVPYAVIEG AVRSVKETLN SQFVENCKGV IQRLTLQEHK MVWNRTTHLW NDCSKIIHQR
TNTVPFDLVP HEDGVDVAVR VLKPLDSVDL GLETVYEKFH PSIQSFTDVI GHYISGERPK
GIQETEEMLK VGATLTGVGE LVLDNNSVRL QPPKQGMQYY LSSQDFDSLL QRQESSVRLW
KVLALVFGFA TCATLFFILR KQYLQRQERL RLKQMQEEFQ EHEAQLLSRA KPEDRESLKS
ACVVCLSSFK SCVFLECGHV CSCTECYRAL PEPKKCPICR QAITRVIPLY NS

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
98	251	Domain	E3 Ubiquitin ligase MUL1-like	IPR022170	PF12483
272	351	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
302	340	Domain	Zinc finger, RING-type	IPR001841	PS50089

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:21597459
GO:0000266	mitochondrial fission	Biological Process	IMP	PMID:18207745
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0009893	positive regulation of metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0010637	negative regulation of mitochondrial fusion	Biological Process	IDA	PMID:19407830
GO:0010821	regulation of mitochondrion organization	Biological Process	IMP	PMID:24898855
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0016925	protein sumoylation	Biological Process	IEA	GO_REF:0000041
GO:0022603	regulation of anatomical structure morphogenesis	Biological Process	IEA	GO_REF:0000117
GO:0031647	regulation of protein stability	Biological Process	IEA	GO_REF:0000120
GO:0031648	protein destabilization	Biological Process	IMP	PMID:24898855
GO:0033235	positive regulation of protein sumoylation	Biological Process	IDA	PMID:19407830
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	HMP	PMID:12761501
GO:0045824	negative regulation of innate immune response	Biological Process	IMP	PMID:23399697
GO:0050689	negative regulation of defense response to virus by host	Biological Process	IMP	PMID:23399697
GO:0050821	protein stabilization	Biological Process	IMP	PMID:19407830
GO:0051094	positive regulation of developmental process	Biological Process	IEA	GO_REF:0000117
GO:0051646	mitochondrion localization	Biological Process	IMP	PMID:18213395
GO:0051881	regulation of mitochondrial membrane potential	Biological Process	IEA	GO_REF:0000107
GO:0051898	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Biological Process	IDA	PMID:22410793
GO:0060339	negative regulation of type I interferon-mediated signaling pathway	Biological Process	IMP	PMID:23399697
GO:0071360	cellular response to exogenous dsRNA	Biological Process	IDA	PMID:23399697
GO:0071650	negative regulation of chemokine (C-C motif) ligand 5 production	Biological Process	IMP	PMID:23399697
GO:0090141	positive regulation of mitochondrial fission	Biological Process	IDA	PMID:19407830
GO:1901028	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	Biological Process	IDA	PMID:18591963
GO:1903861	positive regulation of dendrite extension	Biological Process	IEA	GO_REF:0000107
GO:1905091	positive regulation of type 2 mitophagy	Biological Process	IEA	GO_REF:0000107
GO:0005739	mitochondrion	Cellular Component	IBA	GO_REF:0000033
GO:0005741	mitochondrial outer membrane	Cellular Component	IEA	GO_REF:0000120
GO:0005777	peroxisome	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0030424	axon	Cellular Component	IMP	PMID:24898855
GO:0043025	neuronal cell body	Cellular Component	IMP	PMID:24898855
GO:0002039	p53 binding	Molecular Function	IPI	PMID:21597459
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019789	SUMO transferase activity	Molecular Function	IDA	PMID:19407830
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:19407830
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:18591963
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q969V5	MUL1	Yes	Yes	No	No	—	No	E3-specific
P11021	BIP	Yes	No	No	No	—	No	E3-specific