FBXW5

Details:

UniProt Entry: Q969U6
Gene: FBXW5
Class: Other E3 Components
Family: Receptor
Protein length: 566
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q969U6
MDEGGTPLLP DSLVYQIFLS LGPADVLAAG LVCRQWQAVS RDEFLWREQF YRYYQVARDV
PRHPAAMSWY EEFQRLYDTV PCVEVQTLRE HTDQVLHLSF SHSGYQFASC SKDCTVKIWS
NDLTISLLHS ADMRPYNWSY TQFSQFNKDD SLLLASGVFL GPHNSSSGEI AVISLDSFAL
LSRVRNKPYD VFGCWLTETS LISGNLHRIG DITSCSVLWL NNAFQDVESE NVNVVKRLFK
IQNLNASTVR TVMVADCSRF DSPDLLLEAG DPATSPCRIF DLGSDNEEVV AGPAPAHAKE
GLRHFLDRVL EGRAQPQLSE RMLETKVAEL LAQGHTKPPE RSATGAKSKY LIFTTGCLTY
SPHQIGIKQI LPHQMTTAGP VLGEGRGSDA FFDALDHVID IHGHIIGMGL SPDNRYLYVN
SRAWPNGAVV ADPMQPPPIA EEIDLLVFDL KTMREVRRAL RAHRAYTPND ECFFIFLDVS
RDFVASGAED RHGYIWDRHY NICLARLRHE DVVNSVVFSP QEQELLLTAS DDATIKAWRS
PRTMRVLQAP RPRPRTFFSW LASQRR

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	559	Family	F-box/WD repeat-containing protein 5	IPR042508	PTHR20995
7	50	Domain	F-box domain	IPR001810	PF12937
8	132	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
9	49	Domain	F-box domain	IPR001810	PS50181
9	49	Domain	F-box domain	IPR001810	SM00256
63	192	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
75	544	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
81	120	Repeat	WD40 repeat	IPR001680	SM00320
85	120	Repeat	WD40 repeat	IPR001680	PF00400
88	120	Repeat	WD40 repeat	IPR001680	PS50082
392	553	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
453	497	Repeat	WD40 repeat	IPR001680	SM00320
500	539	Repeat	WD40 repeat	IPR001680	SM00320
506	538	Repeat	WD40 repeat	IPR001680	PS50082

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000002
GO:0007088	regulation of mitotic nuclear division	Biological Process	IEA	GO_REF:0000107
GO:0010564	regulation of cell cycle process	Biological Process	IEA	GO_REF:0000117
GO:0010824	regulation of centrosome duplication	Biological Process	IMP	PMID:21725316
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000120
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:18381890
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000002
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000002
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0005515	protein binding	Molecular Function	IPI	PMID:15070733
GO:0019901	protein kinase binding	Molecular Function	IPI	PMID:21725316

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