TRI63

Details:

UniProt Entry: Q969Q1
Gene: TRIM63
Class: RING
Family: RING5
Protein length: 353
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2d8u, 3ddt, 4m3l

Protein Sequence ▾

>Q969Q1
MDYKSSLIQD GNPMENLEKQ LICPICLEMF TKPVVILPCQ HNLCRKCAND IFQAANPYWT
SRGSSVSMSG GRFRCPTCRH EVIMDRHGVY GLQRNLLVEN IIDIYKQECS SRPLQKGSHP
MCKEHEDEKI NIYCLTCEVP TCSMCKVFGI HKACEVAPLQ SVFQGQKTEL NNCISMLVAG
NDRVQTIITQ LEDSRRVTKE NSHQVKEELS QKFDTLYAIL DEKKSELLQR ITQEQEKKLS
FIEALIQQYQ EQLDKSTKLV ETAIQSLDEP GGATFLLTAK QLIKSIVEAS KGCQLGKTEQ
GFENMDFFTL DLEHIADALR AIDFGTDEEE EEFIEEEDQE EEESTEGKEE GHQ

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
10	112	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
18	80	Domain	E3 ubiquitin-protein ligase TRIM63, RING finger, HC subclass	IPR042667	cd16759
23	76	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
23	79	Domain	Zinc finger, RING-type	IPR001841	PS50089
23	78	Domain	Zinc finger, RING-type	IPR001841	SM00184
39	48	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
117	159	Domain	B-box-type zinc finger	IPR000315	PS50119
117	159	Domain	B-box-type zinc finger	IPR000315	SM00336
120	152	Domain	B-box-type zinc finger	IPR000315	PF00643
267	325	Domain	COS domain	IPR017903	PS51262

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006936	muscle contraction	Biological Process	IEA	GO_REF:0000107
GO:0007165	signal transduction	Biological Process	NAS	PMID:11243782
GO:0010614	negative regulation of cardiac muscle hypertrophy	Biological Process	IEA	GO_REF:0000107
GO:0014732	skeletal muscle atrophy	Biological Process	IEA	GO_REF:0000107
GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation	Biological Process	ISS	GO_REF:0000024
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0045820	negative regulation of glycolytic process	Biological Process	IMP	PMID:34244144
GO:0051384	response to glucocorticoid	Biological Process	IEA	GO_REF:0000107
GO:0070555	response to interleukin-1	Biological Process	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005874	microtubule	Cellular Component	NAS	PMID:11243782
GO:0030018	Z disc	Cellular Component	IEA	GO_REF:0000044
GO:0031430	M band	Cellular Component	IEA	GO_REF:0000044
GO:0043292	contractile muscle fiber	Cellular Component	IEA	GO_REF:0000107
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:18157088
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0031432	titin binding	Molecular Function	IDA	PMID:11927605
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P31937	3HIDH	Yes	Yes	No	No	—	No	E3-specific
Q96A32	MYL11	Yes	Yes	No	No	—	No	E3-specific
P19429	TNNI3	Yes	Yes	No	No	18157088	EBI-7745632	E3-specific
P63316	TNNC1	Yes	No	No	No	—	No	E3-specific
P05976	MYL1	Yes	Yes	No	No	—	No	E3-specific
P19237	TNNI1	Yes	Yes	No	No	—	No	E3-specific
P10916	MLRV	Yes	Yes	No	No	—	No	E3-specific
Q9Y692	GMEB1	Yes	Yes	No	No	18157088	EBI-7745852	E3-specific
Q14324	MYPC2	Yes	Yes	No	No	23414517	EBI-5661341	E3-specific
P06576	ATPB	Yes	Yes	No	No	18157088	EBI-7746611	E3-specific
Q14896	MYPC3	Yes	Yes	No	No	18157088	EBI-7745671	E3-specific
P06732	KCRM	Yes	Yes	No	No	—	No	E3-specific
P10827	THA	Yes	Yes	No	No	—	No	E3-specific
P25963	IKBA	Yes	Yes	No	No	—	No	E3-specific

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