RNF34

Details:

UniProt Entry: Q969K3
Gene: RNF34
Class: RING
Family: RING3
Protein length: 372
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q969K3
MKAGATSMWA SCCGLLNEVM GTGAVRGQQS AFAGATGPFR FTPNPEFSTY PPAATEGPNI
VCKACGLSFS VFRKKHVCCD CKKDFCSVCS VLQENLRRCS TCHLLQETAF QRPQLMRLKV
KDLRQYLILR NIPIDTCREK EDLVDLVLCH HGLGSEDDMD TSSLNSSRSQ TSSFFTRSFF
SNYTAPSATM SSFQGELMDG DQTSRSGVPA QVQSEITSAN TEDDDDDDDE DDDDEEENAE
DRNPGLSKER VRASLSDLSS LDDVEGMSVR QLKEILARNF VNYSGCCEKW ELVEKVNRLY
KENEENQKSY GERLQLQDEE DDSLCRICMD AVIDCVLLEC GHMVTCTKCG KRMSECPICR
QYVVRAVHVF KS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
50	130	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
257	310	Homologous_superfamily	SAP domain superfamily	IPR036361	G3DSA:1.10.720.30
263	299	Homologous_superfamily	SAP domain superfamily	IPR036361	SSF68906
311	372	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
325	360	Domain	Zinc finger, RING-type	IPR001841	PS50089
325	359	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	Biological Process	IMP	PMID:25012219
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0070417	cellular response to cold	Biological Process	IEA	GO_REF:0000107
GO:0070936	protein K48-linked ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:1901796	regulation of signal transduction by p53 class mediator	Biological Process	TAS	Reactome:R-HSA-6806003
GO:1901797	negative regulation of signal transduction by p53 class mediator	Biological Process	IEA	GO_REF:0000117
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	Biological Process	IBA	GO_REF:0000033
GO:2000374	regulation of oxygen metabolic process	Biological Process	ISS	GO_REF:0000024
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000043
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000043
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0016604	nuclear body	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000044
GO:0016607	nuclear speck	Cellular Component	IEA	GO_REF:0000044
GO:0012505	endomembrane system	Cellular Component	IEA	GO_REF:0000044
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0002039	p53 binding	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:15069192
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:18382127
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033
GO:1901981	phosphatidylinositol phosphate binding	Molecular Function	IDA	PMID:15069192

Enzyme–Substrate Interactions ▾


Q9UBK2	PRGC1	Yes	Yes	No	No	—	No	E3-specific
Q92851	CASPA	Yes	Yes	No	No	15069192	EBI-8802549	Cluster-specific
Q9Y239	NOD1	Yes	Yes	No	No	—	No	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q9UBK2	PRGC1	Yes	Yes	No	No	—	No	E3-specific
Q92851	CASPA	Yes	Yes	No	No	15069192	EBI-8802549	Cluster-specific
Q9Y239	NOD1	Yes	Yes	No	No	—	No	E3-specific