FBXW7

>Q969H0
MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQLRQQEE EHTARNGEVV
GVEPRPGGQN DSQQGQLEEN NNRFISVDED SSGNQEEQEE DEEHAGEQDE EDEEEEEMDQ
ESDDFDQSDD SSREDEHTHT NSVTNSSSIV DLPVHQLSSP FYTKTTKMKR KLDHGSEVRS
FSLGKKPCKV SEYTSTTGLV PCSATPTTFG DLRAANGQGQ QRRRITSVQP PTGLQEWLKM
FQSWSGPEKL LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD
LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP WKSAYIRQHR
IDTNWRRGEL KSPKVLKGHD DHVITCLQFC GNRIVSGSDD NTLKVWSAVT GKCLRTLVGH
TGGVWSSQMR DNIIISGSTD RTLKVWNAET GECIHTLYGH TSTVRCMHLH EKRVVSGSRD
ATLRVWDIET GQCLHVLMGH VAAVRCVQYD GRRVVSGAYD FMVKVWDPET ETCLHTLQGH
TNRVYSLQFD GIHVVSGSLD TSIRVWDVET GNCIHTLTGH QSLTSGMELK DNILVSGNAD
STVKIWDIKT GQCLQTLQGP NKHQSAVTCL QFNKNFVITS SDDGTVKLWD LKTGEFIRNL
VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL DFDVDMK

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
264	363	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
278	324	Domain	F-box domain	IPR001810	PS50181
282	325	Domain	F-box domain	IPR001810	PF12937
284	324	Domain	F-box domain	IPR001810	SM00256
368	692	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
368	707	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
369	407	Repeat	WD40 repeat	IPR001680	SM00320
374	407	Repeat	WD40 repeat	IPR001680	PF00400
391	416	Repeat	WD40 repeat	IPR001680	PS50082
410	447	Repeat	WD40 repeat	IPR001680	SM00320
411	447	Repeat	WD40 repeat	IPR001680	PF00400
417	456	Repeat	WD40 repeat	IPR001680	PS50082
434	448	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
450	487	Repeat	WD40 repeat	IPR001680	SM00320
451	487	Repeat	WD40 repeat	IPR001680	PF00400
457	496	Repeat	WD40 repeat	IPR001680	PS50082
474	488	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
474	488	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
490	527	Repeat	WD40 repeat	IPR001680	SM00320
491	527	Repeat	WD40 repeat	IPR001680	PF00400
497	536	Repeat	WD40 repeat	IPR001680	PS50082
530	567	Repeat	WD40 repeat	IPR001680	SM00320
532	567	Repeat	WD40 repeat	IPR001680	PF00400
537	576	Repeat	WD40 repeat	IPR001680	PS50082
554	568	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
570	607	Repeat	WD40 repeat	IPR001680	SM00320
571	607	Repeat	WD40 repeat	IPR001680	PF00400
577	616	Repeat	WD40 repeat	IPR001680	PS50082
594	608	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
594	608	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
610	650	Repeat	WD40 repeat	IPR001680	SM00320
611	650	Repeat	WD40 repeat	IPR001680	PF00400
620	659	Repeat	WD40 repeat	IPR001680	PS50082
637	651	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
637	651	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
653	701	Repeat	WD40 repeat	IPR001680	SM00320

GO term	Name	Ontology	Evidence	Reference
GO:0001944	vasculature development	Biological Process	IEA	GO_REF:0000117
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0031647	regulation of protein stability	Biological Process	IEA	GO_REF:0000117
GO:0042752	regulation of circadian rhythm	Biological Process	IEA	GO_REF:0000117
GO:1901800	positive regulation of proteasomal protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:2001205	negative regulation of osteoclast development	Biological Process	IEA	GO_REF:0000117
GO:0070374	positive regulation of ERK1 and ERK2 cascade	Biological Process	ISS	GO_REF:0000024
GO:0007346	regulation of mitotic cell cycle	Biological Process	IDA	PMID:19160488
GO:0016567	protein ubiquitination	Biological Process	IDA	PMID:12354302
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:20389280
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:19160488
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:24424410
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0007062	sister chromatid cohesion	Biological Process	IMP	PMID:15917200
GO:0010629	negative regulation of gene expression	Biological Process	IMP	PMID:23823476
GO:0010868	negative regulation of triglyceride biosynthetic process	Biological Process	ISS	GO_REF:0000024
GO:0010883	regulation of lipid storage	Biological Process	ISS	GO_REF:0000024
GO:0010992	ubiquitin recycling	Biological Process	IBA	GO_REF:0000033
GO:0031398	positive regulation of protein ubiquitination	Biological Process	IDA	PMID:12628165
GO:0032880	regulation of protein localization	Biological Process	ISS	GO_REF:0000024
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0045746	negative regulation of Notch signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0048511	rhythmic process	Biological Process	IEA	GO_REF:0000043
GO:0050821	protein stabilization	Biological Process	ISS	GO_REF:0000024
GO:0055088	lipid homeostasis	Biological Process	ISS	GO_REF:0000024
GO:1901524	regulation of mitophagy	Biological Process	IMP	PMID:24912190
GO:1902806	regulation of cell cycle G1/S phase transition	Biological Process	TAS	PMID:12628165
GO:1903955	positive regulation of protein targeting to mitochondrion	Biological Process	IMP	PMID:24912190
GO:2000346	negative regulation of hepatocyte proliferation	Biological Process	ISS	GO_REF:0000024
GO:2000639	negative regulation of SREBP signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	IDA	PMID:25438055
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:34102342
GO:0034644	cellular response to UV	Biological Process	IDA	PMID:17873522
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0005730	nucleolus	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IDA	PMID:12628165
GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex	Cellular Component	IPI	PMID:12628165
GO:0032991	protein-containing complex	Cellular Component	IDA	PMID:17873522
GO:0005515	protein binding	Molecular Function	IPI	PMID:15070733
GO:0030332	cyclin binding	Molecular Function	IDA	PMID:12628165
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IDA	PMID:12628165
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:12628165
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:21620836
GO:0043130	ubiquitin binding	Molecular Function	IBA	GO_REF:0000033
GO:0050816	phosphothreonine residue binding	Molecular Function	IDA	PMID:17434132
GO:0097027	ubiquitin-protein transferase activator activity	Molecular Function	IDA	PMID:12628165
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:15150404