CUL5

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Start	End	Type	Name	InterPro	Source
11	776	Family	Cullin	IPR045093	PTHR11932
15	383	Homologous_superfamily	Cullin repeat-like-containing domain superfamily	IPR016159	SSF74788
19	672	Domain	Cullin, N-terminal	IPR001373	PF00888
400	673	Homologous_superfamily	Cullin homology domain superfamily	IPR036317	SSF75632
403	638	Domain	Cullin homology domain	IPR016158	PS50069
435	586	Domain	Cullin homology domain	IPR016158	SM00182
694	780	Homologous_superfamily	Winged helix DNA-binding domain superfamily	IPR036390	SSF46785
694	776	Homologous_superfamily	Winged helix-like DNA-binding domain superfamily	IPR036388	G3DSA:1.10.10.10
707	774	Domain	Cullin protein, neddylation domain	IPR019559	SM00884
711	772	Domain	Cullin protein, neddylation domain	IPR019559	PF10557
753	780	Conserved_site	Cullin, conserved site	IPR016157	PS01256

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0010498	proteasomal protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0038026	reelin-mediated signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0001837	epithelial to mesenchymal transition	Biological Process	IDA	PMID:16096638
GO:0010719	negative regulation of epithelial to mesenchymal transition	Biological Process	IDA	PMID:29059170
GO:0021819	layer formation in cerebral cortex	Biological Process	ISS	GO_REF:0000024
GO:0030968	endoplasmic reticulum unfolded protein response	Biological Process	IDA	PMID:31387940
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:22017875
GO:0038162	erythropoietin-mediated signaling pathway	Biological Process	IDA	PMID:2163696
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	ISS	GO_REF:0000024
GO:0045087	innate immune response	Biological Process	IDA	PMID:22915799
GO:0051607	defense response to virus	Biological Process	IDA	PMID:22915799
GO:0051894	positive regulation of focal adhesion assembly	Biological Process	IMP	PMID:35512830
GO:0051895	negative regulation of focal adhesion assembly	Biological Process	IMP	PMID:35512830
GO:0052170	symbiont-mediated suppression of host innate immune response	Biological Process	IDA	PMID:22190037
GO:0060396	growth hormone receptor signaling pathway	Biological Process	IDA	PMID:2825030
GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	Biological Process	IDA	PMID:12552091
GO:0060400	negative regulation of growth hormone receptor signaling pathway	Biological Process	IDA	PMID:21980433
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:38418882
GO:0140896	cGAS/STING signaling pathway	Biological Process	IDA	PMID:30842659
GO:0160049	negative regulation of cGAS/STING signaling pathway	Biological Process	IDA	PMID:38418882
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	TAS	PMID:8681378
GO:0007165	signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0016477	cell migration	Biological Process	IDA	PMID:35512830
GO:0030335	positive regulation of cell migration	Biological Process	NAS	PMID:33999101
GO:0038128	ERBB2 signaling pathway	Biological Process	TAS	Reactome:R-HSA-1227986
GO:0070588	calcium ion transmembrane transport	Biological Process	IEA	GO_REF:0000108
GO:0070979	protein K11-linked ubiquitination	Biological Process	IDA	PMID:27910872
GO:0097193	intrinsic apoptotic signaling pathway	Biological Process	TAS	PMID:9581826
GO:0120184	negative regulation of focal adhesion disassembly	Biological Process	IDA	PMID:26598620
GO:2001222	regulation of neuron migration	Biological Process	ISS	GO_REF:0000024
GO:0031461	cullin-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000120
GO:0005634	nucleus	Cellular Component	IDA	PMID:38418882
GO:0005737	cytoplasm	Cellular Component	NAS	PMID:26598620
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-180540
GO:0090734	site of DNA damage	Cellular Component	IDA	PMID:28292928
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0031466	Cul5-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IEA	GO_REF:0000002
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	TAS	Reactome:R-HSA-1918095
GO:0005262	calcium channel activity	Molecular Function	TAS	PMID:9581826
GO:0005515	protein binding	Molecular Function	IPI	PMID:12504025
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IBA	GO_REF:0000033
GO:0038023	signaling receptor activity	Molecular Function	TAS	PMID:9581826
GO:0160072	ubiquitin ligase complex scaffold activity	Molecular Function	IDA	PMID:22190037

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CUL5

Details:

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾