KCNB2

Details:

UniProt Entry: Q92953
Gene: KCNB2
Class: Other E3 Components
Family: Adaptor
Protein length: 911
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q92953
MAEKAPPGLN RKTSRSTLSL PPEPVDIIRS KTCSRRVKIN VGGLNHEVLW RTLDRLPRTR
LGKLRDCNTH ESLLEVCDDY NLNENEYFFD RHPGAFTSIL NFYRTGKLHM MEEMCALSFG
QELDYWGIDE IYLESCCQAR YHQKKEQMNE ELRREAETMR EREGEEFDNT CCPDKRKKLW
DLLEKPNSSV AAKILAIVSI LFIVLSTIAL SLNTLPELQE TDEFGQLNDN RQLAHVEAVC
IAWFTMEYLL RFLSSPNKWK FFKGPLNVID LLAILPYYVT IFLTESNKSV LQFQNVRRVV
QIFRIMRILR ILKLARHSTG LQSLGFTLRR SYNELGLLIL FLAMGIMIFS SLVFFAEKDE
DATKFTSIPA SFWWATITMT TVGYGDIYPK TLLGKIVGGL CCIAGVLVIA LPIPIIVNNF
SEFYKEQKRQ EKAIKRREAL ERAKRNGSIV SMNLKDAFAR SMELIDVAVE KAGESANTKD
SADDNHLSPS RWKWARKALS ETSSNKSFEN KYQEVSQKDS HEQLNNTSSS SPQHLSAQKL
EMLYNEITKT QPHSHPNPDC QEKPERPSAY EEEIEMEEVV CPQEQLAVAQ TEVIVDMKST
SSIDSFTSCA TDFTETERSP LPPPSASHLQ MKFPTDLPGT EEHQRARGPP FLTLSREKGP
AARDGTLEYA PVDITVNLDA SGSQCGLHSP LQSDNATDSP KSSLKGSNPL KSRSLKVNFK
ENRGSAPQTP PSTARPLPVT TADFSLTTPQ HISTILLEET PSQGDRPLLG TEVSAPCQGP
SKGLSPRFPK QKLFPFSSRE RRSFTEIDTG DDEDFLELPG AREEKQVDSS PNCFADKPSD
GRDPLREEGS VGSSSPQDTG HNCRQDIYHA VSEVKKDSSQ EGCKMENHLF APEIHSNPGD
TGYCPTRETS M

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
27	156	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
35	144	Domain	BTB/POZ domain	IPR000210	SM00225
35	144	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
37	136	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214
86	96	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
134	147	Family	Potassium channel, voltage dependent, Kv2	IPR003973	PR01495
167	317	Homologous_superfamily	Voltage-dependent channel domain superfamily	IPR027359	G3DSA:1.20.120.350
169	183	Family	Potassium channel, voltage dependent, Kv2	IPR003973	PR01495
193	427	Domain	Ion transport domain	IPR005821	PF00520
257	270	Family	Potassium channel, voltage dependent, Kv2	IPR003973	PR01495
310	318	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
334	348	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
398	409	Family	Potassium channel, voltage dependent, Kv2	IPR003973	PR01495
405	416	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
421	432	Family	Potassium channel, voltage dependent, Kv2	IPR003973	PR01495
455	470	Family	Potassium channel, voltage dependent, Kv2	IPR003973	PR01495
471	759	Family	Potassium channel, voltage dependent, Kv2	IPR003973	PF03521
471	485	Family	Potassium channel, voltage dependent, Kv2.2	IPR005826	PR01515
512	527	Family	Potassium channel, voltage dependent, Kv2.2	IPR005826	PR01515
538	552	Family	Potassium channel, voltage dependent, Kv2.2	IPR005826	PR01515
557	567	Family	Potassium channel, voltage dependent, Kv2.2	IPR005826	PR01515
571	585	Family	Potassium channel, voltage dependent, Kv2.2	IPR005826	PR01515
619	636	Family	Potassium channel, voltage dependent, Kv2.2	IPR005826	PR01515
709	721	Family	Potassium channel, voltage dependent, Kv2.2	IPR005826	PR01515

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0001508	action potential	Biological Process	IBA	GO_REF:0000033
GO:0006811	monoatomic ion transport	Biological Process	IEA	GO_REF:0000120
GO:0006813	potassium ion transport	Biological Process	ISS	GO_REF:0000024
GO:0006940	regulation of smooth muscle contraction	Biological Process	TAS	PMID:9612272
GO:0034220	monoatomic ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0055085	transmembrane transport	Biological Process	IEA	GO_REF:0000002
GO:0071805	potassium ion transmembrane transport	Biological Process	ISS	GO_REF:0000024
GO:0072659	protein localization to plasma membrane	Biological Process	ISS	GO_REF:0000024
GO:0016020	membrane	Cellular Component	IBA	GO_REF:0000033
GO:0030425	dendrite	Cellular Component	IBA	GO_REF:0000033
GO:0043025	neuronal cell body	Cellular Component	IBA	GO_REF:0000033
GO:0005886	plasma membrane	Cellular Component	ISS	GO_REF:0000024
GO:0032809	neuronal cell body membrane	Cellular Component	ISS	GO_REF:0000024
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0043204	perikaryon	Cellular Component	IEA	GO_REF:0000044
GO:0008076	voltage-gated potassium channel complex	Cellular Component	IEA	GO_REF:0000002
GO:0034702	monoatomic ion channel complex	Cellular Component	IEA	GO_REF:0000043
GO:0005216	monoatomic ion channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005251	delayed rectifier potassium channel activity	Molecular Function	ISS	GO_REF:0000024
GO:0005267	potassium channel activity	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:33124732
GO:0015459	potassium channel regulator activity	Molecular Function	IBA	GO_REF:0000033
GO:0046982	protein heterodimerization activity	Molecular Function	ISS	GO_REF:0000024

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL2324356	ChEMBL	7.0	—	—	CC(C)C(=O)Nc1ccc(N(C)C)c(C(=O)N[C@@H](C)c2ccccc2)c1

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