>Q92794 MVKLANPLYT EWILEAIKKV KKQKQRPSEE RICNAVSSSH GLDRKTVLEQ LELSVKDGTI LKVSNKGLNS YKDPDNPGRI ALPKPRNHGK LDNKQNVDWN KLIKRAVEGL AESGGSTLKS IERFLKGQKD VSALFGGSAA SGFHQQLRLA IKRAIGHGRL LKDGPLYRLN TKATNVDGKE SCESLSCLPP VSLLPHEKDK PVAEPIPICS FCLGTKEQNR EKKPEELISC ADCGNSGHPS CLKFSPELTV RVKALRWQCI ECKTCSSCRD QGKNADNMLF CDSCDRGFHM ECCDPPLTRM PKGMWICQIC RPRKKGRKLL QKKAAQIKRR YTNPIGRPKN RLKKQNTVSK GPFSKVRTGP GRGRKRKITL SSQSASSSSE EGYLERIDGL DFCRDSNVSL KFNKKTKGLI DGLTKFFTPS PDGRKARGEV VDYSEQYRIR KRGNRKSSTS DWPTDNQDGW DGKQENEERL FGSQEIMTEK DMELFRDIQE QALQKVGVTG PPDPQVRCPS VIEFGKYEIH TWYSSPYPQE YSRLPKLYLC EFCLKYMKSR TILQQHMKKC GWFHPPANEI YRKNNISVFE VDGNVSTIYC QNLCLLAKLF LDHKTLYYDV EPFLFYVLTQ NDVKGCHLVG YFSKEKHCQQ KYNVSCIMIL PQYQRKGYGR FLIDFSYLLS KREGQAGSPE KPLSDLGRLS YMAYWKSVIL ECLYHQNDKQ ISIKKLSKLT GICPQDITST LHHLRMLDFR SDQFVIIRRE KLIQDHMAKL QLNLRPVDVD PECLRWTPVI VSNSVVSEEE EEEAEEGENE EPQCQERELE ISVGKSVSHE NKEQDSYSVE SEKKPEVMAP VSSTRLSKQV LPHDSLPANS QPSRRGRWGR KNRKTQERFG DKDSKLLLEE TSSAPQEQYG ECGEKSEATQ EQYTESEEQL VASEEQPSQD GKPDLPKRRL SEGVEPWRGQ LKKSPEALKC RLTEGSERLP RRYSEGDRAV LRGFSESSEE EEEPESPRSS SPPILTKPTL KRKKPFLHRR RRVRKRKHHN SSVVTETISE TTEVLDEPFE DSDSERPMPR LEPTFEIDEE EEEEDENELF PREYFRRLSS QDVLRCQSSS KRKSKDEEED EESDDADDTP ILKPVSLLRK RDVKNSPLEP DTSTPLKKKK GWPKGKSRKP IHWKKRPGRK PGFKLSREIM PVSTQACVIE PIVSIPKAGR KPKIQESEET VEPKEDMPLP EERKEEEEMQ AEAEEAEEGE EEDAASSEVP AASPADSSNS PETETKEPEV EEEEEKPRVS EEQRQSEEEQ QELEEPEPEE EEDAAAETAQ NDDHDADDED DGHLESTKKK ELEEQPTRED VKEEPGVQES FLDANMQKSR EKIKDKEETE LDSEEEQPSH DTSVVSEQMA GSEDDHEEDS HTKEELIELK EEEEIPHSEL DLETVQAVQS LTQEESSEHE GAYQDCEETL AACQTLQSYT QADEDPQMSM VEDCHASEHN SPISSVQSHP SQSVRSVSSP NVPALESGYT QISPEQGSLS APSMQNMETS PMMDVPSVSD HSQQVVDSGF SDLGSIESTT ENYENPSSYD STMGGSICGN SSSQSSCSYG GLSSSSSLTQ SSCVVTQQMA SMGSSCSMMQ QSSVQPAANC SIKSPQSCVV ERPPSNQQQQ PPPPPPQQPQ PPPPQPQPAP QPPPPQQQPQ QQPQPQPQQP PPPPPPQQQP PLSQCSMNNS FTPAPMIMEI PESGSTGNIS IYERIPGDFG AGSYSQPSAT FSLAKLQQLT NTIMDPHAMP YSHSPAVTSY ATSVSLSNTG LAQLAPSHPL AGTPQAQATM TPPPNLASTT MNLTSPLLQC NMSATNIGIP HTQRLQGQMP VKGHISIRSK SAPLPSAAAH QQQLYGRSPS AVAMQAGPRA LAVQRGMNMG VNLMPTPAYN VNSMNMNTLN AMNSYRMTQP MMNSSYHSNP AYMNQTAQYP MQMQMGMMGS QAYTQQPMQP NPHGNMMYTG PSHHSYMNAA GVPKQSLNGP YMRR
The same domains may appear in multiple rows, following InterPro convention.
| Start | End | Type | Name | InterPro | Source |
|---|---|---|---|---|---|
| 85 | 165 | Domain | Linker histone H1/H5, domain H15 | IPR005818 | SM00526 |
| 92 | 180 | Homologous_superfamily | Winged helix-like DNA-binding domain superfamily | IPR036388 | G3DSA:1.10.10.10 |
| 92 | 175 | Homologous_superfamily | Winged helix DNA-binding domain superfamily | IPR036390 | SSF46785 |
| 95 | 171 | Domain | Linker histone H1/H5, domain H15 | IPR005818 | PS51504 |
| 195 | 263 | Homologous_superfamily | Zinc finger, FYVE/PHD-type | IPR011011 | SSF57903 |
| 203 | 313 | Homologous_superfamily | Zinc finger, RING/FYVE/PHD-type | IPR013083 | G3DSA:3.30.40.10 |
| 206 | 265 | Domain | Zinc finger, PHD-finger | IPR019787 | PS50016 |
| 208 | 263 | Domain | Zinc finger, PHD-type | IPR001965 | SM00249 |
| 251 | 322 | Homologous_superfamily | Zinc finger, FYVE/PHD-type | IPR011011 | SSF57903 |
| 262 | 313 | Domain | Zinc finger, PHD-finger | IPR019787 | PS50016 |
| 264 | 311 | Domain | Zinc finger, PHD-type | IPR001965 | SM00249 |
| 265 | 312 | Domain | Zinc finger, PHD-finger | IPR019787 | PF00628 |
| 504 | 778 | Domain | Histone acetyltransferase domain, MYST-type | IPR002717 | PS51726 |
| 506 | 560 | Domain | MYST, zinc finger domain | IPR040706 | PF17772 |
| 508 | 776 | Homologous_superfamily | Acyl-CoA N-acyltransferase | IPR016181 | SSF55729 |
| 565 | 741 | Domain | Histone acetyltransferase domain, MYST-type | IPR002717 | PF01853 |
| 683 | 766 | Homologous_superfamily | Winged helix-like DNA-binding domain superfamily | IPR036388 | G3DSA:1.10.10.10 |
| GO term | Name | Ontology | Evidence | Reference |
|---|---|---|---|---|
| GO:0006325 | chromatin organization | Biological Process | IEA | GO_REF:0000043 |
| GO:0006334 | nucleosome assembly | Biological Process | IEA | GO_REF:0000002 |
| GO:0006355 | regulation of DNA-templated transcription | Biological Process | IEA | GO_REF:0000002 |
| GO:0045892 | negative regulation of DNA-templated transcription | Biological Process | IEA | GO_REF:0000104 |
| GO:0045893 | positive regulation of DNA-templated transcription | Biological Process | IEA | GO_REF:0000108 |
| GO:0006338 | chromatin remodeling | Biological Process | IEA | GO_REF:0000120 |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | Biological Process | IEA | GO_REF:0000117 |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | Biological Process | IEA | GO_REF:0000117 |
| GO:0006357 | regulation of transcription by RNA polymerase II | Biological Process | IBA | GO_REF:0000033 |
| GO:0006473 | protein acetylation | Biological Process | IDA | PMID:23431171 |
| GO:0010628 | positive regulation of gene expression | Biological Process | IEA | GO_REF:0000107 |
| GO:0030099 | myeloid cell differentiation | Biological Process | IDA | PMID:11742995 |
| GO:0050793 | regulation of developmental process | Biological Process | NAS | PMID:16387653 |
| GO:0051276 | chromosome organization | Biological Process | TAS | PMID:8782817 |
| GO:0090398 | cellular senescence | Biological Process | IMP | PMID:23431171 |
| GO:1901796 | regulation of signal transduction by p53 class mediator | Biological Process | TAS | Reactome:R-HSA-6804758 |
| GO:1903706 | regulation of hemopoiesis | Biological Process | NAS | PMID:16387653 |
| GO:0005634 | nucleus | Cellular Component | IEA | GO_REF:0000120 |
| GO:0005730 | nucleolus | Cellular Component | IDA | GO_REF:0000052 |
| GO:0005829 | cytosol | Cellular Component | IDA | GO_REF:0000052 |
| GO:0016607 | nuclear speck | Cellular Component | IDA | GO_REF:0000052 |
| GO:0000786 | nucleosome | Cellular Component | IEA | GO_REF:0000002 |
| GO:0070776 | MOZ/MORF histone acetyltransferase complex | Cellular Component | IEA | GO_REF:0000117 |
| GO:0000123 | histone acetyltransferase complex | Cellular Component | IEA | GO_REF:0000117 |
| GO:0000785 | chromatin | Cellular Component | IBA | GO_REF:0000033 |
| GO:0005654 | nucleoplasm | Cellular Component | IEA | GO_REF:0000044 |
| GO:0016605 | PML body | Cellular Component | IEA | GO_REF:0000044 |
| GO:0003677 | DNA binding | Molecular Function | IEA | GO_REF:0000002 |
| GO:0003713 | transcription coactivator activity | Molecular Function | IEA | GO_REF:0000117 |
| GO:0004402 | histone acetyltransferase activity | Molecular Function | IEA | GO_REF:0000120 |
| GO:0008270 | zinc ion binding | Molecular Function | IEA | GO_REF:0000043 |
| GO:0016740 | transferase activity | Molecular Function | IEA | GO_REF:0000043 |
| GO:0016746 | acyltransferase activity | Molecular Function | IEA | GO_REF:0000043 |
| GO:0036408 | histone H3K14 acetyltransferase activity | Molecular Function | IEA | GO_REF:0000117 |
| GO:0046872 | metal ion binding | Molecular Function | IEA | GO_REF:0000043 |
| GO:0061733 | protein-lysine-acetyltransferase activity | Molecular Function | IEA | GO_REF:0000116 |
| GO:0003682 | chromatin binding | Molecular Function | IBA | GO_REF:0000033 |
| GO:0003712 | transcription coregulator activity | Molecular Function | IBA | GO_REF:0000033 |
| GO:0005515 | protein binding | Molecular Function | IPI | PMID:11965546 |
| GO:0010484 | histone H3 acetyltransferase activity | Molecular Function | IBA | GO_REF:0000033 |
| GO:0016407 | acetyltransferase activity | Molecular Function | TAS | Reactome:R-HSA-6805638 |
| GO:0043995 | histone H4K5 acetyltransferase activity | Molecular Function | IDA | PMID:11742995 |
| GO:0043996 | histone H4K8 acetyltransferase activity | Molecular Function | IDA | PMID:11742995 |
| GO:0043997 | histone H4K12 acetyltransferase activity | Molecular Function | IDA | PMID:11742995 |
| GO:0046972 | histone H4K16 acetyltransferase activity | Molecular Function | IDA | PMID:11742995 |
| GO:0140297 | DNA-binding transcription factor binding | Molecular Function | IPI | PMID:11742995 |
| Substrate | Name | Known ESI (UbiBrowser) |
Known ESI (UbiNet) |
PPI (IntAct direct) PSI-MI score ≥ 0.5 |
PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs |
PubMed Ref. | IntAct Ref. | Substrate Specificity |
|---|
| Type | ChEMBL Compound ID | Source | pChEMBL | PDB Compound ID | PDB Codes | SMILES |
|---|---|---|---|---|---|---|
| E3 Binder | CHEMBL4528681 | ChEMBL | 6.92 | — | — | C#CCOc1ccc(F)c(C(=O)NNS(=O)(=O)c2ccccc2)c1 |
| E3 Binder | CHEMBL4573736 | ChEMBL | 7.77 | — | — | C=C(C)COc1cc(C)c(F)c(C(=O)NNS(=O)(=O)c2ccccc2)c1 |
| E3 Binder | CHEMBL4464572 | ChEMBL | 7.27 | O9P | — | C=CCOc1cc(C)c(F)c(C(=O)NNS(=O)(=O)c2ccccc2)c1 |
| E3 Binder | CHEMBL4518462 | ChEMBL | 7.8 | — | — | C=CCOc1cc(C)cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4455027 | ChEMBL | 7.7 | — | — | C=CCOc1cc(F)cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4437223 | ChEMBL | 7.16 | — | — | C=CCOc1ccc(F)c(C(=O)NNS(=O)(=O)c2ccccc2)c1 |
| E3 Binder | CHEMBL4450971 | ChEMBL | 7.52 | — | — | C=CCOc1cccc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4467591 | ChEMBL | 6.62 | — | — | CC(C)COc1cccc(C(=O)NNS(=O)(=O)c2ccccc2)c1 |
| E3 Binder | CHEMBL4578485 | ChEMBL | 7.1 | — | — | CC(C)COc1cccc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4537104 | ChEMBL | 7.21 | — | — | CC(C)Oc1cc(F)cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4474916 | ChEMBL | 7.21 | — | — | CC(C)Oc1ccc(F)c(C(=O)NNS(=O)(=O)c2ccccc2)c1 |
| E3 Binder | CHEMBL4439103 | ChEMBL | 6.48 | — | — | CC(C)Oc1cccc(C(=O)NNS(=O)(=O)c2ccccc2)c1 |
| E3 Binder | CHEMBL4468268 | ChEMBL | 7.23 | — | — | CC(C)Oc1cccc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4566381 | ChEMBL | 6.01 | — | — | CC(C)c1cccc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4522271 | ChEMBL | 6.64 | — | — | CCCCOc1cccc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4560554 | ChEMBL | 7.28 | O9V | — | CCCOc1cc(C)c(F)c(C(=O)NNS(=O)(=O)c2ccccc2)c1 |
| E3 Binder | CHEMBL4592414 | ChEMBL | 6.4 | — | — | CCCOc1cc(F)cc(C(=O)NNS(=O)(=O)c2ccccc2)c1 |
| E3 Binder | CHEMBL4453580 | ChEMBL | 7.14 | — | — | CCCOc1cc(F)cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4470108 | ChEMBL | 7.09 | — | — | CCCOc1ccc(F)c(C(=O)NNS(=O)(=O)c2ccccc2)c1 |
| E3 Binder | CHEMBL4445917 | ChEMBL | 6.92 | — | — | CCCOc1cccc(C(=O)NNS(=O)(=O)c2ccc3ccccc3c2)c1 |
| E3 Binder | CHEMBL4460681 | ChEMBL | 6.42 | — | — | CCCOc1cccc(C(=O)NNS(=O)(=O)c2ccccc2)c1 |
| E3 Binder | CHEMBL4578978 | ChEMBL | 7.03 | — | — | CCCOc1cccc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4525271 | ChEMBL | 7.03 | — | — | CCCc1cccc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4554392 | ChEMBL | 7.54 | — | — | CCOCc1cc(C)c(F)c(C(=O)NNS(=O)(=O)c2ccccc2)c1 |
| E3 Binder | CHEMBL4530056 | ChEMBL | 7.62 | — | — | CCOCc1cc(C)cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4517118 | ChEMBL | 7.09 | O9A | — | CCOc1cc(C)c(F)c(C(=O)NNS(=O)(=O)c2ccc3ccccc3c2)c1 |
| E3 Binder | CHEMBL4443232 | ChEMBL | 7.21 | O9D | — | CCOc1cc(C)c(F)c(C(=O)NNS(=O)(=O)c2ccccc2)c1 |
| E3 Binder | CHEMBL4474246 | ChEMBL | 7.13 | — | — | CCOc1cc(C)c(F)c(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4460862 | ChEMBL | 6.89 | — | — | CCOc1cc(C)cc(C(=O)NNS(=O)(=O)c2c(F)cccc2F)c1 |
| E3 Binder | CHEMBL4471809 | ChEMBL | 6.92 | — | — | CCOc1cc(C)cc(C(=O)NNS(=O)(=O)c2cc(C)ccc2F)c1 |
| E3 Binder | CHEMBL4462661 | ChEMBL | 6.77 | — | — | CCOc1cc(C)cc(C(=O)NNS(=O)(=O)c2cc(F)ccc2F)c1 |
| E3 Binder | CHEMBL4435522 | ChEMBL | 6.75 | — | — | CCOc1cc(C)cc(C(=O)NNS(=O)(=O)c2ccc(C)cc2F)c1 |
| E3 Binder | CHEMBL4556282 | ChEMBL | 6.89 | — | — | CCOc1cc(C)cc(C(=O)NNS(=O)(=O)c2ccc(F)cc2F)c1 |
| E3 Binder | CHEMBL4449214 | ChEMBL | 6.8 | — | — | CCOc1cc(C)cc(C(=O)NNS(=O)(=O)c2cccc(C)c2F)c1 |
| E3 Binder | CHEMBL4536734 | ChEMBL | 6.77 | — | — | CCOc1cc(C)cc(C(=O)NNS(=O)(=O)c2cccc(F)c2F)c1 |
| E3 Binder | CHEMBL4446917 | ChEMBL | 7.8 | — | — | CCOc1cc(C)cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4569652 | ChEMBL | 6.96 | — | — | CCOc1cc(F)cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4585500 | ChEMBL | 6.8 | — | — | CCOc1cc(OC)cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4465335 | ChEMBL | 6.72 | — | — | CCOc1ccc(F)c(C(=O)NNS(=O)(=O)c2ccccc2)c1 |
| E3 Binder | CHEMBL4559264 | ChEMBL | 6.28 | — | — | CCOc1cccc(C(=O)NNS(=O)(=O)c2cc(Br)ccc2F)c1 |
| E3 Binder | CHEMBL4471477 | ChEMBL | 6.57 | — | — | CCOc1cccc(C(=O)NNS(=O)(=O)c2cc(OC)ccc2F)c1 |
| E3 Binder | CHEMBL4449967 | ChEMBL | 6.24 | — | — | CCOc1cccc(C(=O)NNS(=O)(=O)c2ccc3ccccc3c2)c1 |
| E3 Binder | CHEMBL4463902 | ChEMBL | 6.43 | — | — | CCOc1cccc(C(=O)NNS(=O)(=O)c2ccccc2)c1 |
| E3 Binder | CHEMBL4445093 | ChEMBL | 7.16 | — | — | CCOc1cccc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4452390 | ChEMBL | 7.21 | — | — | CCc1cccc(C(=O)NNS(=O)(=O)c2ccc3ccccc3c2)c1F |
| E3 Binder | CHEMBL4548248 | ChEMBL | 6.24 | — | — | CCc1cccc(C(=O)NNS(=O)(=O)c2ccccc2)c1F |
| E3 Binder | CHEMBL4441536 | ChEMBL | 6.66 | — | — | CCc1cccc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4448443 | ChEMBL | 6.41 | — | — | COc1cc(C(=O)NNS(=O)(=O)c2ccccc2)cc(-c2ccccn2)c1 |
| E3 Binder | CHEMBL4593009 | ChEMBL | 6.32 | — | — | COc1cc(C(=O)NNS(=O)(=O)c2ccccc2)cc(-c2ccco2)c1 |
| E3 Binder | CHEMBL4468749 | ChEMBL | 6.17 | — | — | COc1cc(C(=O)NNS(=O)(=O)c2ccccc2)cc(-c2ncccn2)c1 |
| E3 Binder | CHEMBL4468833 | ChEMBL | 8.3 | — | — | COc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-c2ccccn2)c1 |
| E3 Binder | CHEMBL4463739 | ChEMBL | 6.96 | — | — | COc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-c2ccco2)c1 |
| E3 Binder | CHEMBL4453559 | ChEMBL | 7.62 | — | — | COc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-c2ncccn2)c1 |
| E3 Binder | CHEMBL4532593 | ChEMBL | 6.69 | — | — | COc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-n2ccc(C)n2)c1 |
| E3 Binder | CHEMBL4465716 | ChEMBL | 7.89 | — | — | COc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-n2cccn2)c1 |
| E3 Binder | CHEMBL4467522 | ChEMBL | 6.96 | — | — | COc1cc(OC(C)C)cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4571175 | ChEMBL | 7.14 | — | — | COc1ccc(F)c(S(=O)(=O)NNC(=O)c2cc(C)cc(-n3cccn3)c2)c1 |
| E3 Binder | CHEMBL4472224 | ChEMBL | 7.0 | — | — | COc1ccc(F)c(S(=O)(=O)NNC(=O)c2cc(F)cc(-n3cccn3)c2)c1 |
| E3 Binder | CHEMBL4444115 | ChEMBL | 6.89 | — | — | COc1ccc(S(=O)(=O)NNC(=O)c2cc(F)cc(-c3ccccc3)c2)c(F)c1 |
| E3 Binder | CHEMBL4585890 | ChEMBL | 6.46 | — | — | COc1ccc(S(=O)(=O)NNC(=O)c2cc(F)cc(-n3cccn3)c2)c(F)c1 |
| E3 Binder | CHEMBL4532880 | ChEMBL | 6.16 | — | — | COc1cccc(C(=O)NNS(=O)(=O)c2ccc3ccccc3c2)c1 |
| E3 Binder | CHEMBL4474924 | ChEMBL | 6.31 | — | — | COc1cccc(C(=O)NNS(=O)(=O)c2ccccc2)c1F |
| E3 Binder | CHEMBL4446489 | ChEMBL | 6.96 | — | — | COc1cccc(F)c1S(=O)(=O)NNC(=O)c1cc(C)cc(-n2cccn2)c1 |
| E3 Binder | CHEMBL4554281 | ChEMBL | 6.57 | — | — | COc1cccc(S(=O)(=O)NNC(=O)c2cc(F)cc(-n3cccn3)c2)c1F |
| E3 Binder | CHEMBL4455897 | ChEMBL | 8.1 | 7KM | — | Cc1cc(-c2ccccc2)cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F |
| E3 Binder | CHEMBL4444077 | ChEMBL | 7.32 | — | — | Cc1cc(-c2ccccc2)cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1F |
| E3 Binder | CHEMBL4462062 | ChEMBL | 7.14 | — | — | Cc1cc(-c2ccccn2)cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F |
| E3 Binder | CHEMBL4571483 | ChEMBL | 7.1 | — | — | Cc1cc(-c2ccco2)cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F |
| E3 Binder | CHEMBL4449359 | ChEMBL | 7.17 | O9M | — | Cc1cc(-c2ncccn2)cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F |
| E3 Binder | CHEMBL4475866 | ChEMBL | 7.28 | — | — | Cc1cc(-n2cc(F)cn2)cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F |
| E3 Binder | CHEMBL4581401 | ChEMBL | 7.11 | O9G | — | Cc1cc(-n2cccn2)cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F |
| E3 Binder | CHEMBL4517015 | ChEMBL | 7.06 | — | — | Cc1cc(-n2nccc2C)cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F |
| E3 Binder | CHEMBL4563600 | ChEMBL | 7.02 | — | — | Cc1cc(-n2nccn2)cc(C(=O)NNS(=O)(=O)c2ccc3ccccc3c2)c1F |
| E3 Binder | CHEMBL4461380 | ChEMBL | 7.42 | O9Y | — | Cc1cc(-n2nccn2)cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F |
| E3 Binder | CHEMBL4516365 | ChEMBL | 6.75 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2c(F)cccc2F)cc(-n2cccn2)c1 |
| E3 Binder | CHEMBL4446274 | ChEMBL | 7.02 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2cc(C)ccc2F)cc(-n2cccn2)c1 |
| E3 Binder | CHEMBL4444785 | ChEMBL | 6.64 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2cc(O)ccc2F)cc(-n2cccn2)c1 |
| E3 Binder | CHEMBL4551030 | ChEMBL | 6.92 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2ccc(C)cc2F)cc(-n2cccn2)c1 |
| E3 Binder | CHEMBL4451002 | ChEMBL | 6.75 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2ccc(F)cc2F)cc(-n2cccn2)c1 |
| E3 Binder | CHEMBL4589194 | ChEMBL | 6.41 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2cccc(C)c2F)cc(-n2cccn2)c1 |
| E3 Binder | CHEMBL4562799 | ChEMBL | 6.64 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2cccc(F)c2F)cc(-n2cccn2)c1 |
| E3 Binder | CHEMBL4590827 | ChEMBL | 6.28 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2cccc(O)c2F)cc(-n2cccn2)c1 |
| E3 Binder | CHEMBL4454131 | ChEMBL | 6.89 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2)cc(-c2ccco2)c1 |
| E3 Binder | CHEMBL4455764 | ChEMBL | 6.64 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2)cc(-c2ncccn2)c1 |
| E3 Binder | CHEMBL4517852 | ChEMBL | 6.22 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2)cc(-n2cc(F)cn2)c1 |
| E3 Binder | CHEMBL4464974 | ChEMBL | 7.36 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)c(F)c(-c2ccccn2)c1 |
| E3 Binder | CHEMBL4576670 | ChEMBL | 7.21 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)c(F)c(-n2cccn2)c1 |
| E3 Binder | CHEMBL4539384 | ChEMBL | 8.1 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-c2ccccn2)c1 |
| E3 Binder | CHEMBL4458272 | ChEMBL | 7.96 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-c2ccco2)c1 |
| E3 Binder | CHEMBL4441439 | ChEMBL | 8.05 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-c2ncccn2)c1 |
| E3 Binder | CHEMBL4436877 | ChEMBL | 7.85 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-n2cc(C)cn2)c1 |
| E3 Binder | CHEMBL4526110 | ChEMBL | 7.54 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-n2cc(F)cn2)c1 |
| E3 Binder | CHEMBL4475883 | ChEMBL | 8.15 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-n2ccc(C)n2)c1 |
| E3 Binder | CHEMBL4454507 | ChEMBL | 7.57 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-n2cccn2)c1 |
| E3 Binder | CHEMBL4445473 | ChEMBL | 7.89 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-n2nccc2C)c1 |
| E3 Binder | CHEMBL4566403 | ChEMBL | 7.75 | — | — | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-n2nccn2)c1 |
| E3 Binder | CHEMBL4437810 | ChEMBL | 6.75 | — | — | Cc1cc(C)n(-c2cccc(C(=O)NNS(=O)(=O)c3ccccc3F)c2)n1 |
| E3 Binder | CHEMBL4513861 | ChEMBL | 7.2 | O9S | — | Cc1cc(OC(C)C)cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F |
| E3 Binder | CHEMBL4449163 | ChEMBL | 7.82 | — | — | Cc1cc(OC(C)C)cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4559662 | ChEMBL | 7.57 | — | — | Cc1cc(OC2CC2)cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4524297 | ChEMBL | 7.21 | — | — | Cc1cc(OCC2CC2)cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F |
| E3 Binder | CHEMBL4588326 | ChEMBL | 7.05 | — | — | Cc1cc(OCC2CC2)cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4579833 | ChEMBL | 6.04 | — | — | Cc1ccc(F)c(C(=O)NNS(=O)(=O)c2ccc3ccccc3c2)c1 |
| E3 Binder | CHEMBL4520147 | ChEMBL | 6.92 | MLS | — | Cc1cccc(C(=O)NNS(=O)(=O)c2ccc3ccccc3c2)c1F |
| E3 Binder | CHEMBL4440486 | ChEMBL | 6.64 | — | — | Cc1cccc(C(=O)NNS(=O)(=O)c2ccccc2)c1F |
| E3 Binder | CHEMBL4590691 | ChEMBL | 6.42 | — | — | Cc1cccc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4561274 | ChEMBL | 7.19 | — | — | Cc1ccn(-c2cc(C)c(F)c(C(=O)NNS(=O)(=O)c3ccccc3)c2)n1 |
| E3 Binder | CHEMBL4451724 | ChEMBL | 6.37 | — | — | Cc1ccn(-c2cc(F)cc(C(=O)NNS(=O)(=O)c3ccccc3)c2)n1 |
| E3 Binder | CHEMBL4456874 | ChEMBL | 7.64 | — | — | Cc1ccn(-c2cc(F)cc(C(=O)NNS(=O)(=O)c3ccccc3F)c2)n1 |
| E3 Binder | CHEMBL4456078 | ChEMBL | 6.8 | — | — | Cc1ccn(-c2ccc(F)c(C(=O)NNS(=O)(=O)c3ccccc3)c2)n1 |
| E3 Binder | CHEMBL4588945 | ChEMBL | 7.75 | — | — | Cc1ccn(-c2cccc(C(=O)NNS(=O)(=O)c3ccccc3F)c2)n1 |
| E3 Binder | CHEMBL4446616 | ChEMBL | 7.51 | — | — | Cc1ccnn1-c1cc(F)cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4556380 | ChEMBL | 7.08 | — | — | Cc1cnn(-c2cc(C)c(F)c(C(=O)NNS(=O)(=O)c3ccccc3)c2)c1 |
| E3 Binder | CHEMBL4459368 | ChEMBL | 6.1 | — | — | Cc1cnn(-c2cc(F)cc(C(=O)NNS(=O)(=O)c3ccccc3)c2)c1 |
| E3 Binder | CHEMBL4441001 | ChEMBL | 7.5 | — | — | Cc1cnn(-c2cc(F)cc(C(=O)NNS(=O)(=O)c3ccccc3F)c2)c1 |
| E3 Binder | CHEMBL4463475 | ChEMBL | 6.66 | — | — | Cc1cnn(-c2ccc(F)c(C(=O)NNS(=O)(=O)c3ccccc3)c2)c1 |
| E3 Binder | CHEMBL4549881 | ChEMBL | 6.52 | — | — | Cc1cnn(-c2cccc(C(=O)NNS(=O)(=O)c3ccccc3F)c2)c1 |
| E3 Binder | CHEMBL4525503 | ChEMBL | 6.31 | — | — | Nc1cccc(S(=O)(=O)NNC(=O)c2ccccc2F)c1 |
| E3 Binder | CHEMBL4445456 | ChEMBL | 7.58 | — | — | O=C(NNS(=O)(=O)c1cc(O)ccc1F)c1cc(F)cc(-n2cccn2)c1 |
| E3 Binder | CHEMBL4576525 | ChEMBL | 6.0 | — | — | O=C(NNS(=O)(=O)c1ccc(Br)cc1)c1ccccc1F |
| E3 Binder | CHEMBL4539347 | ChEMBL | 7.21 | — | — | O=C(NNS(=O)(=O)c1ccc(O)cc1F)c1cc(F)cc(-c2ccccc2)c1 |
| E3 Binder | CHEMBL4582784 | ChEMBL | 6.06 | — | — | O=C(NNS(=O)(=O)c1ccc2ccccc2c1)c1cccc(-c2ccccc2)c1 |
| E3 Binder | CHEMBL4476153 | ChEMBL | 7.11 | — | — | O=C(NNS(=O)(=O)c1ccc2ccccc2c1)c1cccc(C(F)(F)F)c1F |
| E3 Binder | CHEMBL4455584 | ChEMBL | 6.28 | — | — | O=C(NNS(=O)(=O)c1ccc2ccccc2c1)c1cccc(Cl)c1 |
| E3 Binder | CHEMBL4473722 | ChEMBL | 7.37 | — | — | O=C(NNS(=O)(=O)c1ccc2ccccc2c1)c1cccc(Cl)c1F |
| E3 Binder | CHEMBL4455492 | ChEMBL | 6.89 | — | — | O=C(NNS(=O)(=O)c1ccc2ccccc2c1)c1cccc(F)c1F |
| E3 Binder | CHEMBL4470091 | ChEMBL | 6.31 | MQJ | — | O=C(NNS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1F |
| E3 Binder | CHEMBL4467566 | ChEMBL | 6.34 | — | — | O=C(NNS(=O)(=O)c1cccc(Br)c1)c1ccccc1F |
| E3 Binder | CHEMBL4552095 | ChEMBL | 6.72 | — | — | O=C(NNS(=O)(=O)c1cccc(O)c1F)c1cc(F)cc(-c2ccccc2)c1 |
| E3 Binder | CHEMBL4564003 | ChEMBL | 6.57 | — | — | O=C(NNS(=O)(=O)c1cccc(O)c1F)c1cc(F)cc(-c2ccccn2)c1 |
| E3 Binder | CHEMBL4464835 | ChEMBL | 8.0 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cc(-c2ccccc2)cc(Cl)c1F |
| E3 Binder | CHEMBL4460509 | ChEMBL | 7.77 | MNJ | — | O=C(NNS(=O)(=O)c1ccccc1)c1cc(-c2ccccc2)ccc1F |
| E3 Binder | CHEMBL4581333 | ChEMBL | 7.05 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cc(-c2ccccn2)ccc1F |
| E3 Binder | CHEMBL4540514 | ChEMBL | 6.92 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cc(-c2ccco2)ccc1F |
| E3 Binder | CHEMBL4475957 | ChEMBL | 6.85 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cc(-c2ncccn2)ccc1F |
| E3 Binder | CHEMBL4476346 | ChEMBL | 6.85 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cc(-n2cccn2)ccc1F |
| E3 Binder | CHEMBL4535983 | ChEMBL | 6.47 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cc(-n2nccn2)ccc1F |
| E3 Binder | CHEMBL4580493 | ChEMBL | 6.96 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cc(Cl)cc(-c2ccco2)c1 |
| E3 Binder | CHEMBL4528993 | ChEMBL | 8.7 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cc(F)cc(-c2ccccn2)c1 |
| E3 Binder | CHEMBL4434925 | ChEMBL | 6.85 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cc(F)cc(-c2ccco2)c1 |
| E3 Binder | CHEMBL4470229 | ChEMBL | 6.35 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cc(F)cc(-c2ncccn2)c1 |
| E3 Binder | CHEMBL4581040 | ChEMBL | 6.36 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cc(F)cc(-n2cccn2)c1 |
| E3 Binder | CHEMBL4467378 | ChEMBL | 6.96 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cc(F)cc(OCC2CC2)c1 |
| E3 Binder | CHEMBL4542711 | ChEMBL | 6.1 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cccc(-c2cccc(Cl)c2)c1 |
| E3 Binder | CHEMBL4562274 | ChEMBL | 6.54 | ML7 | — | O=C(NNS(=O)(=O)c1ccccc1)c1cccc(-c2ccccc2)c1 |
| E3 Binder | CHEMBL4474291 | ChEMBL | 6.57 | MLV | — | O=C(NNS(=O)(=O)c1ccccc1)c1cccc(-c2ccccc2)c1F |
| E3 Binder | CHEMBL4582659 | ChEMBL | 6.21 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cccc(-c2ccccc2F)c1 |
| E3 Binder | CHEMBL4437534 | ChEMBL | 6.85 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cccc(-c2ccccn2)c1 |
| E3 Binder | CHEMBL4538005 | ChEMBL | 6.8 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cccc(-c2cccs2)c1 |
| E3 Binder | CHEMBL4450582 | ChEMBL | 6.57 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cccc(-c2cscn2)c1 |
| E3 Binder | CHEMBL4561694 | ChEMBL | 6.2 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cccc(-c2ncccn2)c1 |
| E3 Binder | CHEMBL4461279 | ChEMBL | 6.8 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cccc(-c2nccs2)c1 |
| E3 Binder | CHEMBL4471104 | ChEMBL | 6.21 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cccc(-n2cccn2)c1 |
| E3 Binder | CHEMBL4444803 | ChEMBL | 6.41 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cccc(C(F)(F)F)c1F |
| E3 Binder | CHEMBL4442753 | ChEMBL | 6.89 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cccc(Cl)c1F |
| E3 Binder | CHEMBL4473410 | ChEMBL | 6.13 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cccc(F)c1F |
| E3 Binder | CHEMBL4475994 | ChEMBL | 6.36 | — | — | O=C(NNS(=O)(=O)c1ccccc1)c1cccc(OC2CCCC2)c1 |
| E3 Binder | CHEMBL4593500 | ChEMBL | 7.77 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cc(Cl)cc(-c2ccccc2)c1F |
| E3 Binder | CHEMBL4437798 | ChEMBL | 8.26 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cc(Cl)cc(-c2ccco2)c1 |
| E3 Binder | CHEMBL4593937 | ChEMBL | 7.62 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cc(Cl)cc(-c2cccs2)c1 |
| E3 Binder | CHEMBL4456585 | ChEMBL | 8.7 | FCV | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cc(F)cc(-c2ccccn2)c1 |
| E3 Binder | CHEMBL4565790 | ChEMBL | 8.03 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cc(F)cc(-c2ccco2)c1 |
| E3 Binder | CHEMBL4516984 | ChEMBL | 7.85 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cc(F)cc(-c2ncccn2)c1 |
| E3 Binder | CHEMBL4464911 | ChEMBL | 7.64 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cc(F)cc(-n2cccn2)c1 |
| E3 Binder | CHEMBL4521125 | ChEMBL | 8.05 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cc(F)cc(-n2nccn2)c1 |
| E3 Binder | CHEMBL4590077 | ChEMBL | 7.04 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cc(F)cc(OCC2CC2)c1 |
| E3 Binder | CHEMBL4439158 | ChEMBL | 6.64 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1ccc2ccccc2c1 |
| E3 Binder | CHEMBL4483705 | ChEMBL | 6.85 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cccc(-c2ccccc2)c1 |
| E3 Binder | CHEMBL4466823 | ChEMBL | 8.22 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cccc(-c2ccccn2)c1 |
| E3 Binder | CHEMBL4572653 | ChEMBL | 7.7 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cccc(-c2ccco2)c1 |
| E3 Binder | CHEMBL4454163 | ChEMBL | 7.6 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cccc(-c2cccs2)c1 |
| E3 Binder | CHEMBL4541948 | ChEMBL | 7.85 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cccc(-c2ccsc2)c1 |
| E3 Binder | CHEMBL4465155 | ChEMBL | 7.27 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cccc(-c2ncccn2)c1 |
| E3 Binder | CHEMBL4553520 | ChEMBL | 6.31 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cccc(-c2ncon2)c1 |
| E3 Binder | CHEMBL4439337 | ChEMBL | 6.47 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cccc(-n2cc(F)cn2)c1 |
| E3 Binder | CHEMBL4451170 | ChEMBL | 7.37 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cccc(-n2cccn2)c1 |
| E3 Binder | CHEMBL4467238 | ChEMBL | 6.75 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cccc(Br)c1 |
| E3 Binder | CHEMBL4464519 | ChEMBL | 7.22 | NBJ | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cccc(I)c1 |
| E3 Binder | CHEMBL4569365 | ChEMBL | 6.25 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cccc(OC(F)(F)F)c1 |
| E3 Binder | CHEMBL4450945 | ChEMBL | 6.64 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cccc(OC2CCCC2)c1 |
| E3 Binder | CHEMBL4453322 | ChEMBL | 6.92 | — | — | O=C(NNS(=O)(=O)c1ccccc1F)c1cccc(OCC2CCCCC2)c1 |
| E3 Binder | CHEMBL4530847 | ChEMBL | 6.1 | NB7 | — | O=C(NNS(=O)(=O)c1ccccc1F)c1ccccc1 |