>Q92793 MAENLLDGPP NPKRAKLSSP GFSANDSTDF GSLFDLENDL PDELIPNGGE LGLLNSGNLV PDAASKHKQL SELLRGGSGS SINPGIGNVS ASSPVQQGLG GQAQGQPNSA NMASLSAMGK SPLSQGDSSA PSLPKQAAST SGPTPAASQA LNPQAQKQVG LATSSPATSQ TGPGICMNAN FNQTHPGLLN SNSGHSLINQ ASQGQAQVMN GSLGAAGRGR GAGMPYPTPA MQGASSSVLA ETLTQVSPQM TGHAGLNTAQ AGGMAKMGIT GNTSPFGQPF SQAGGQPMGA TGVNPQLASK QSMVNSLPTF PTDIKNTSVT NVPNMSQMQT SVGIVPTQAI ATGPTADPEK RKLIQQQLVL LLHAHKCQRR EQANGEVRAC SLPHCRTMKN VLNHMTHCQA GKACQVAHCA SSRQIISHWK NCTRHDCPVC LPLKNASDKR NQQTILGSPA SGIQNTIGSV GTGQQNATSL SNPNPIDPSS MQRAYAALGL PYMNQPQTQL QPQVPGQQPA QPQTHQQMRT LNPLGNNPMN IPAGGITTDQ QPPNLISESA LPTSLGATNP LMNDGSNSGN IGTLSTIPTA APPSSTGVRK GWHEHVTQDL RSHLVHKLVQ AIFPTPDPAA LKDRRMENLV AYAKKVEGDM YESANSRDEY YHLLAEKIYK IQKELEEKRR SRLHKQGILG NQPALPAPGA QPPVIPQAQP VRPPNGPLSL PVNRMQVSQG MNSFNPMSLG NVQLPQAPMG PRAASPMNHS VQMNSMGSVP GMAISPSRMP QPPNMMGAHT NNMMAQAPAQ SQFLPQNQFP SSSGAMSVGM GQPPAQTGVS QGQVPGAALP NPLNMLGPQA SQLPCPPVTQ SPLHPTPPPA STAAGMPSLQ HTTPPGMTPP QPAAPTQPST PVSSSGQTPT PTPGSVPSAT QTQSTPTVQA AAQAQVTPQP QTPVQPPSVA TPQSSQQQPT PVHAQPPGTP LSQAAASIDN RVPTPSSVAS AETNSQQPGP DVPVLEMKTE TQAEDTEPDP GESKGEPRSE MMEEDLQGAS QVKEETDIAE QKSEPMEVDE KKPEVKVEVK EEEESSSNGT ASQSTSPSQP RKKIFKPEEL RQALMPTLEA LYRQDPESLP FRQPVDPQLL GIPDYFDIVK NPMDLSTIKR KLDTGQYQEP WQYVDDVWLM FNNAWLYNRK TSRVYKFCSK LAEVFEQEID PVMQSLGYCC GRKYEFSPQT LCCYGKQLCT IPRDAAYYSY QNRYHFCEKC FTEIQGENVT LGDDPSQPQT TISKDQFEKK KNDTLDPEPF VDCKECGRKM HQICVLHYDI IWPSGFVCDN CLKKTGRPRK ENKFSAKRLQ TTRLGNHLED RVNKFLRRQN HPEAGEVFVR VVASSDKTVE VKPGMKSRFV DSGEMSESFP YRTKALFAFE EIDGVDVCFF GMHVQEYGSD CPPPNTRRVY ISYLDSIHFF RPRCLRTAVY HEILIGYLEY VKKLGYVTGH IWACPPSEGD DYIFHCHPPD QKIPKPKRLQ EWYKKMLDKA FAERIIHDYK DIFKQATEDR LTSAKELPYF EGDFWPNVLE ESIKELEQEE EERKKEESTA ASETTEGSQG DSKNAKKKNN KKTNKNKSSI SRANKKKPSM PNVSNDLSQK LYATMEKHKE VFFVIHLHAG PVINTLPPIV DPDPLLSCDL MDGRDAFLTL ARDKHWEFSS LRRSKWSTLC MLVELHTQGQ DRFVYTCNEC KHHVETRWHC TVCEDYDLCI NCYNTKSHAH KMVKWGLGLD DEGSSQGEPQ SKSPQESRRL SIQRCIQSLV HACQCRNANC SLPSCQKMKR VVQHTKGCKR KTNGGCPVCK QLIALCCYHA KHCQENKCPV PFCLNIKHKL RQQQIQHRLQ QAQLMRRRMA TMNTRNVPQQ SLPSPTSAPP GTPTQQPSTP QTPQPPAQPQ PSPVSMSPAG FPSVARTQPP TTVSTGKPTS QVPAPPPPAQ PPPAAVEAAR QIEREAQQQQ HLYRVNINNS MPPGRTGMGT PGSQMAPVSL NVPRPNQVSG PVMPSMPPGQ WQQAPLPQQQ PMPGLPRPVI SMQAQAAVAG PRMPSVQPPR SISPSALQDL LRTLKSPSSP QQQQQVLNIL KSNPQLMAAF IKQRTAKYVA NQPGMQPQPG LQSQPGMQPQ PGMHQQPSLQ NLNAMQAGVP RPGVPPQQQA MGGLNPQGQA LNIMNPGHNP NMASMNPQYR EMLRRQLLQQ QQQQQQQQQQ QQQQQQGSAG MAGGMAGHGQ FQQPQGPGGY PPAMQQQQRM QQHLPLQGSS MGQMAAQMGQ LGQMGQPGLG ADSTPNIQQA LQQRILQQQQ MKQQIGSPGQ PNPMSPQQHM LSGQPQASHL PGQQIATSLS NQVRSPAPVQ SPRPQSQPPH SSPSPRIQPQ PSPHHVSPQT GSPHPGLAVT MASSIDQGHL GNPEQSAMLP QLNTPSRSAL SSELSLVGDT TGDTLEKFVE GL
The same domains may appear in multiple rows, following InterPro convention.
| Start | End | Type | Name | InterPro | Source |
|---|---|---|---|---|---|
| 8 | 1876 | Family | Histone acetyltransferase Rtt109/CBP | IPR013178 | PTHR13808 |
| 340 | 439 | Homologous_superfamily | TAZ domain superfamily | IPR035898 | G3DSA:1.20.1020.10 |
| 344 | 438 | Homologous_superfamily | TAZ domain superfamily | IPR035898 | SSF57933 |
| 347 | 433 | Domain | Zinc finger, TAZ-type | IPR000197 | PS50134 |
| 348 | 433 | Domain | Zinc finger, TAZ-type | IPR000197 | SM00551 |
| 354 | 430 | Domain | Zinc finger, TAZ-type | IPR000197 | PF02135 |
| 587 | 666 | Domain | Coactivator CBP, KIX domain | IPR003101 | PS50952 |
| 587 | 673 | Homologous_superfamily | Coactivator CBP, KIX domain superfamily | IPR036529 | G3DSA:1.10.246.20 |
| 588 | 667 | Domain | Coactivator CBP, KIX domain | IPR003101 | PF02172 |
| 589 | 672 | Homologous_superfamily | Coactivator CBP, KIX domain superfamily | IPR036529 | SSF47040 |
| 1072 | 1197 | Homologous_superfamily | Bromodomain-like superfamily | IPR036427 | SSF47370 |
| 1080 | 1197 | Homologous_superfamily | Bromodomain-like superfamily | IPR036427 | G3DSA:1.20.920.10 |
| 1084 | 1194 | Domain | Bromodomain | IPR001487 | SM00297 |
| 1103 | 1175 | Domain | Bromodomain | IPR001487 | PS50014 |
| 1104 | 1177 | Domain | Bromodomain | IPR001487 | PF00439 |
| 1106 | 1119 | Domain | Bromodomain | IPR001487 | PR00503 |
| 1108 | 1167 | Conserved_site | Bromodomain, conserved site | IPR018359 | PS00633 |
| 1122 | 1138 | Domain | Bromodomain | IPR001487 | PR00503 |
| 1138 | 1156 | Domain | Bromodomain | IPR001487 | PR00503 |
| 1156 | 1175 | Domain | Bromodomain | IPR001487 | PR00503 |
| 1192 | 1231 | Domain | CREB-binding protein/p300, atypical RING domain | IPR010303 | PF06001 |
| 1206 | 1273 | Homologous_superfamily | CBP/p300, atypical RING domain superfamily | IPR038547 | G3DSA:2.10.110.40 |
| 1206 | 1278 | Domain | CREB-binding protein/p300, atypical RING domain | IPR010303 | cd15802 |
| 1274 | 1318 | Homologous_superfamily | Zinc finger, RING/FYVE/PHD-type | IPR013083 | G3DSA:3.30.40.10 |
| 1323 | 1700 | Domain | CBP/p300-type histone acetyltransferase domain | IPR031162 | PS51727 |
| 1342 | 1640 | Family | Histone acetyltransferase Rtt109/CBP | IPR013178 | PF08214 |
| 1342 | 1648 | Family | Histone acetyltransferase Rtt109/CBP | IPR013178 | SM01250 |
| 1699 | 1751 | Homologous_superfamily | Zinc finger, ZZ-type superfamily | IPR043145 | G3DSA:3.30.60.90 |
| 1701 | 1742 | Domain | Zinc finger, ZZ-type | IPR000433 | SM00291 |
| 1702 | 1750 | Domain | Zinc finger, ZZ-type | IPR000433 | PS50135 |
| 1702 | 1742 | Domain | Zinc finger, ZZ-type | IPR000433 | PF00569 |
| 1707 | 1732 | Domain | Zinc finger, ZZ-type | IPR000433 | PS01357 |
| 1760 | 1873 | Homologous_superfamily | TAZ domain superfamily | IPR035898 | G3DSA:1.20.1020.10 |
| 1764 | 1848 | Homologous_superfamily | TAZ domain superfamily | IPR035898 | SSF57933 |
| 1765 | 1846 | Domain | Zinc finger, TAZ-type | IPR000197 | PS50134 |
| 1766 | 1844 | Domain | Zinc finger, TAZ-type | IPR000197 | SM00551 |
| 1772 | 1843 | Domain | Zinc finger, TAZ-type | IPR000197 | PF02135 |
| 2014 | 2113 | Domain | Nuclear receptor coactivator, CREB-bp-like, interlocking | IPR014744 | PF09030 |
| 2059 | 2115 | Homologous_superfamily | Nuclear receptor coactivator, interlocking | IPR009110 | SSF69125 |
| 2060 | 2109 | Homologous_superfamily | Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily | IPR037073 | G3DSA:1.10.1630.10 |
| GO term | Name | Ontology | Evidence | Reference |
|---|---|---|---|---|
| GO:0006338 | chromatin remodeling | Biological Process | IEA | GO_REF:0000108 |
| GO:0006355 | regulation of DNA-templated transcription | Biological Process | IEA | GO_REF:0000002 |
| GO:0006325 | chromatin organization | Biological Process | IEA | GO_REF:0000043 |
| GO:0000724 | double-strand break repair via homologous recombination | Biological Process | IDA | PMID:29670289 |
| GO:0006357 | regulation of transcription by RNA polymerase II | Biological Process | IDA | PMID:35675826 |
| GO:0007249 | canonical NF-kappaB signal transduction | Biological Process | IDA | PMID:12048232 |
| GO:0031669 | cellular response to nutrient levels | Biological Process | IDA | PMID:35675826 |
| GO:0050821 | protein stabilization | Biological Process | IDA | PMID:35675826 |
| GO:0071108 | protein K48-linked deubiquitination | Biological Process | IDA | PMID:35675826 |
| GO:0097009 | energy homeostasis | Biological Process | IDA | PMID:35675826 |
| GO:1900182 | positive regulation of protein localization to nucleus | Biological Process | IDA | PMID:35675826 |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | Biological Process | IDA | PMID:21539536 |
| GO:0001666 | response to hypoxia | Biological Process | IEA | GO_REF:0000117 |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | Biological Process | IEA | GO_REF:0000117 |
| GO:0006473 | protein acetylation | Biological Process | IDA | PMID:15273251 |
| GO:0007165 | signal transduction | Biological Process | NAS | PMID:15261140 |
| GO:0008589 | regulation of smoothened signaling pathway | Biological Process | TAS | PMID:11001584 |
| GO:0016479 | negative regulation of transcription by RNA polymerase I | Biological Process | IDA | PMID:30540930 |
| GO:0018076 | N-terminal peptidyl-lysine acetylation | Biological Process | IDA | PMID:12435739 |
| GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | Biological Process | IEA | GO_REF:0000117 |
| GO:0031648 | protein destabilization | Biological Process | IEA | GO_REF:0000117 |
| GO:0034644 | cellular response to UV | Biological Process | IEA | GO_REF:0000117 |
| GO:0042592 | homeostatic process | Biological Process | NAS | PMID:15261140 |
| GO:0042733 | embryonic digit morphogenesis | Biological Process | TAS | PMID:11001584 |
| GO:0045893 | positive regulation of DNA-templated transcription | Biological Process | ISS | GO_REF:0000024 |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | Biological Process | IBA | GO_REF:0000033 |
| GO:0048511 | rhythmic process | Biological Process | IEA | GO_REF:0000043 |
| GO:0065003 | protein-containing complex assembly | Biological Process | TAS | PMID:7913207 |
| GO:1900034 | regulation of cellular response to heat | Biological Process | IEA | GO_REF:0000117 |
| GO:1905168 | positive regulation of double-strand break repair via homologous recombination | Biological Process | IDA | PMID:38128537 |
| GO:0005634 | nucleus | Cellular Component | IEA | GO_REF:0000120 |
| GO:0005654 | nucleoplasm | Cellular Component | IEA | GO_REF:0000117 |
| GO:0016604 | nuclear body | Cellular Component | IDA | GO_REF:0000052 |
| GO:0005737 | cytoplasm | Cellular Component | IDA | PMID:35675826 |
| GO:0000785 | chromatin | Cellular Component | IDA | PMID:21539536 |
| GO:0005829 | cytosol | Cellular Component | TAS | Reactome:R-HSA-9756494 |
| GO:0000123 | histone acetyltransferase complex | Cellular Component | IEA | GO_REF:0000002 |
| GO:0005667 | transcription regulator complex | Cellular Component | IBA | GO_REF:0000033 |
| GO:0008270 | zinc ion binding | Molecular Function | IEA | GO_REF:0000120 |
| GO:0046872 | metal ion binding | Molecular Function | IEA | GO_REF:0000043 |
| GO:0004402 | histone acetyltransferase activity | Molecular Function | IEA | GO_REF:0000120 |
| GO:0016740 | transferase activity | Molecular Function | IEA | GO_REF:0000043 |
| GO:0003712 | transcription coregulator activity | Molecular Function | IEA | GO_REF:0000002 |
| GO:0001223 | transcription coactivator binding | Molecular Function | IEA | GO_REF:0000117 |
| GO:0002039 | p53 binding | Molecular Function | IPI | PMID:9194565 |
| GO:0003682 | chromatin binding | Molecular Function | IEA | GO_REF:0000117 |
| GO:0003684 | damaged DNA binding | Molecular Function | IEA | GO_REF:0000117 |
| GO:0003713 | transcription coactivator activity | Molecular Function | IBA | GO_REF:0000033 |
| GO:0003714 | transcription corepressor activity | Molecular Function | IDA | PMID:21539536 |
| GO:0005515 | protein binding | Molecular Function | IPI | PMID:10049825 |
| GO:0016407 | acetyltransferase activity | Molecular Function | IDA | PMID:11742995 |
| GO:0016746 | acyltransferase activity | Molecular Function | IEA | GO_REF:0000043 |
| GO:0031490 | chromatin DNA binding | Molecular Function | IBA | GO_REF:0000033 |
| GO:0043426 | MRF binding | Molecular Function | IDA | PMID:8621548 |
| GO:0043993 | histone H3K18 acetyltransferase activity | Molecular Function | IEA | GO_REF:0000117 |
| GO:0044017 | histone H3K27 acetyltransferase activity | Molecular Function | IEA | GO_REF:0000117 |
| GO:0048156 | tau protein binding | Molecular Function | TAS | PMID:28386764 |
| GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | Molecular Function | IEA | GO_REF:0000117 |
| GO:0061733 | protein-lysine-acetyltransferase activity | Molecular Function | IEA | GO_REF:0000116 |
| GO:0120300 | peptide lactyltransferase (CoA-dependent) activity | Molecular Function | IEA | GO_REF:0000120 |
| GO:0140297 | DNA-binding transcription factor binding | Molecular Function | IPI | PMID:15509593 |
| Substrate | Name | Known ESI (UbiBrowser) |
Known ESI (UbiNet) |
PPI (IntAct direct) PSI-MI score ≥ 0.5 |
PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs |
PubMed Ref. | IntAct Ref. | Substrate Specificity |
|---|
| Type | ChEMBL Compound ID | Source | pChEMBL | PDB Compound ID | PDB Codes | SMILES |
|---|---|---|---|---|---|---|
| E3 Binder | CHEMBL3899464 | ChEMBL | 6.52 | — | — | CC(=O)N1CCc2[nH]nc(Nc3ccc(C)cc3)c2C1 |
| E3 Binder | CHEMBL3947092 | ChEMBL | 6.04 | — | — | CC(=O)N1CCc2[nH]nc(Nc3ccc(F)cc3)c2C1 |
| E3 Binder | CHEMBL3898753 | ChEMBL | 7.0 | — | — | CC(=O)N1CCc2[nH]nc(Nc3cccc(C(F)(F)F)c3)c2C1 |
| E3 Binder | CHEMBL3970636 | ChEMBL | 6.47 | — | — | CC(=O)N1CCc2[nH]nc(Nc3cccc(C)c3)c2C1 |
| E3 Binder | CHEMBL3908519 | ChEMBL | 6.37 | — | — | CC(=O)N1CCc2[nH]nc(Nc3cccc(F)c3)c2C1 |
| E3 Binder | CHEMBL3891644 | ChEMBL | 6.8 | — | — | CC(=O)N1CCc2[nH]nc(Nc3cccc(OC(F)F)c3)c2C1 |
| E3 Binder | CHEMBL3959584 | ChEMBL | 6.21 | — | — | CC(=O)N1CCc2[nH]nc(Nc3ccccc3)c2C1 |
| E3 Binder | CHEMBL4204065 | ChEMBL | 8.62 | — | — | CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cn(C)nc5C#N)ncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4209361 | ChEMBL | 8.48 | — | — | CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cn(C)nc5C(F)F)ncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4203082 | ChEMBL | 8.92 | — | — | CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cnn(C)c5)ncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4204490 | ChEMBL | 8.48 | — | — | CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cnn(C)c5C#N)ncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4207965 | ChEMBL | 8.55 | — | — | CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cnn(C)c5C(F)F)ncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4076748 | ChEMBL | 8.96 | 9UD | — | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL3985118 | ChEMBL | 7.4 | — | — | CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C)c4)cc3)nn2C)C1 |
| E3 Binder | CHEMBL3915331 | ChEMBL | 7.4 | — | — | CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C)c4)cc3)nn2C2COC2)C1 |
| E3 Binder | CHEMBL3917504 | ChEMBL | 7.7 | — | — | CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C)c4)cc3)nn2CC2CC2)C1 |
| E3 Binder | CHEMBL3896323 | ChEMBL | 7.7 | — | — | CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C)c4)cc3)nn2[C@@H]2CCOC2)C1 |
| E3 Binder | CHEMBL3924330 | ChEMBL | 7.52 | — | — | CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C)c4)cc3)nn2[C@H]2CCOC2)C1 |
| E3 Binder | CHEMBL3968533 | ChEMBL | 7.7 | — | — | CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C)c4)cc3F)nn2[C@@H]2CCOC2)C1 |
| E3 Binder | CHEMBL3911524 | ChEMBL | 7.52 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(-c4cc[nH]n4)c3)nn2CC2CC2)C1 |
| E3 Binder | CHEMBL3902514 | ChEMBL | 8.0 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(-c4ccccc4)c3)nn2CC2CC2)C1 |
| E3 Binder | CHEMBL3973515 | ChEMBL | 7.52 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(-c4ccccn4)c3)nn2CC2CC2)C1 |
| E3 Binder | CHEMBL3893541 | ChEMBL | 7.52 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(-c4cccnc4)c3)nn2CC2CC2)C1 |
| E3 Binder | CHEMBL3962542 | ChEMBL | 7.7 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(-c4ccncc4)c3)nn2CC2CC2)C1 |
| E3 Binder | CHEMBL3938408 | ChEMBL | 7.52 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(-c4ccnn4C)c3)nn2CC2CC2)C1 |
| E3 Binder | CHEMBL3892467 | ChEMBL | 7.52 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(-c4cn[nH]c4)c3)nn2CC2CC2)C1 |
| E3 Binder | CHEMBL3981511 | ChEMBL | 7.7 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(-c4cnn(C)c4)c3)nn2CC2CC2)C1 |
| E3 Binder | CHEMBL3920459 | ChEMBL | 7.52 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(-c4cnoc4)c3)nn2CC2CC2)C1 |
| E3 Binder | CHEMBL3943463 | ChEMBL | 6.44 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(C(=O)N(C)C)c3)nn2CC2CC2)C1 |
| E3 Binder | CHEMBL3889679 | ChEMBL | 7.52 | 6XG | — | CC(=O)N1CCc2c(c(Nc3cccc(C(=O)NC(C)C)c3)nn2CC2CC2)C1 |
| E3 Binder | CHEMBL3972721 | ChEMBL | 6.7 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2C)C1 |
| E3 Binder | CHEMBL3900573 | ChEMBL | 6.82 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2C2CC2)C1 |
| E3 Binder | CHEMBL3962757 | ChEMBL | 7.22 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2CC2CC2)C1 |
| E3 Binder | CHEMBL3928531 | ChEMBL | 6.66 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2CCC#N)C1 |
| E3 Binder | CHEMBL3909879 | ChEMBL | 6.75 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2CCC2CC2)C1 |
| E3 Binder | CHEMBL3891576 | ChEMBL | 6.51 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2CCO)C1 |
| E3 Binder | CHEMBL3897524 | ChEMBL | 6.85 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2Cc2ccccc2)C1 |
| E3 Binder | CHEMBL3936675 | ChEMBL | 7.05 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2Cc2ccccn2)C1 |
| E3 Binder | CHEMBL3986361 | ChEMBL | 6.85 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2Cc2cccnc2)C1 |
| E3 Binder | CHEMBL3916599 | ChEMBL | 6.7 | — | — | CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2Cc2ccncc2)C1 |
| E3 Binder | CHEMBL505121 | ChEMBL | 7.72 | — | — | CC(=O)N[C@@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O)C(N)=O |
| E3 Binder | CHEMBL4167383 | ChEMBL | 6.11 | — | — | CC(=O)Nc1ccc2c(c1)CCC21NC(=O)N(CC(=O)N(Cc2ccccc2)C(C)C2CC2)C1=O |
| E3 Binder | CHEMBL4159164 | ChEMBL | 6.19 | — | — | CC(=O)n1cc(C(=O)Nc2cc(C(=O)O)cc(-c3ccco3)c2)c2ccccc21 |
| E3 Binder | CHEMBL3734823 | ChEMBL | 8.59 | — | — | CC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C/c1ccc(-c2cc(C)c(C)cc2[N+](=O)[O-])o1 |
| E3 Binder | CHEMBL3927642 | ChEMBL | 6.87 | 6F9 | — | CCC(=O)N1CCOc2c(cc(-c3cc(OC)cc(OC)c3)cc2C(=O)N[C@H]2CCCN(C)C2)C1 |
| E3 Binder | CHEMBL3774655 | ChEMBL | 6.82 | — | — | CCC(=O)N1CCOc2c(cc(-c3ccc(OC)c(OC)c3)cc2OC[C@H]2CCCN(C)C2)C1 |
| E3 Binder | CHEMBL3934488 | ChEMBL | 7.52 | — | — | CCCNC(=O)c1cccc(Nc2nn(CC3CC3)c3c2CN(C(C)=O)CC3)c1 |
| E3 Binder | CHEMBL3980755 | ChEMBL | 7.16 | — | — | CCCn1nc(Nc2cccc(C)c2)c2c1CCN(C(C)=O)C2 |
| E3 Binder | CHEMBL3906525 | ChEMBL | 7.4 | — | — | CCNC(=O)c1cccc(Nc2nn(CC3CC3)c3c2CN(C(C)=O)CC3)c1 |
| E3 Binder | CHEMBL5074479 | ChEMBL | 6.64 | — | — | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)O |
| E3 Binder | CHEMBL5080878 | ChEMBL | 7.44 | — | — | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O |
| E3 Binder | CHEMBL5074760 | ChEMBL | 7.67 | — | — | CC[C@H](C)[C@H](NC(=O)[C@@H]1CNC(=O)[C@@H](N)CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)CC)C(C)C |
| E3 Binder | CHEMBL5092869 | ChEMBL | 7.65 | — | — | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC)C(C)C |
| E3 Binder | CHEMBL5081656 | ChEMBL | 7.53 | — | — | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC)C(C)C |
| E3 Binder | CHEMBL5090131 | ChEMBL | 7.75 | — | — | CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O |
| E3 Binder | CHEMBL5087442 | ChEMBL | 7.43 | — | — | CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O |
| E3 Binder | CHEMBL5084183 | ChEMBL | 7.47 | — | — | CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H]1CNC(=O)[C@@H](N)CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N1)C(C)C)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O |
| E3 Binder | CHEMBL5088177 | ChEMBL | 7.5 | — | — | CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O |
| E3 Binder | CHEMBL4741587 | ChEMBL | 6.64 | 99E | — | CCc1c(C(=O)NCc2c(O)ccc3cccc(O)c23)[nH]c(C)c1C(C)=O |
| E3 Binder | CHEMBL3935734 | ChEMBL | 6.6 | — | — | CCc1ccc(Nc2n[nH]c3c2CN(C(C)=O)CC3)cc1 |
| E3 Binder | CHEMBL3963381 | ChEMBL | 6.72 | — | — | CCc1cccc(Nc2n[nH]c3c2CN(C(C)=O)CC3)c1 |
| E3 Binder | CHEMBL3769507 | ChEMBL | 6.13 | H1B | — | CCn1cc(-c2cccc(C(F)(F)F)c2)c2sc(C(=N)NC3CCS(=O)(=O)CC3)cc2c1=O |
| E3 Binder | CHEMBL3910675 | ChEMBL | 7.05 | — | — | CCn1nc(Nc2cccc(C)c2)c2c1CCN(C(C)=O)C2 |
| E3 Binder | CHEMBL4436408 | ChEMBL | 6.25 | 67B | — | CN(C)C(=O)c1cccc(-c2cn(C)c(=O)c3[nH]ccc23)c1 |
| E3 Binder | CHEMBL4468788 | ChEMBL | 6.22 | — | — | CN1C(=O)[C@]2(Cc3ccc(CCc4ccc(C[C@@]56SS[C@@](CO)(C(=O)N5C)N(C)C6=O)cc4)cc3)SS[C@@]1(CO)C(=O)N2C |
| E3 Binder | CHEMBL4217213 | ChEMBL | 9.05 | — | — | CNC(=O)N1CCc2c(c(-c3cccc4cc(-c5cnn(C)c5)c(C(F)F)cc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4097025 | ChEMBL | 9.03 | 9U4 | — | CNC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL5083020 | ChEMBL | 8.09 | — | — | CNC(=O)Nc1cc2c(cc1F)[C@@]1(CC2)OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O |
| E3 Binder | CHEMBL4173894 | ChEMBL | 6.62 | — | — | CNC(=O)Nc1ccc2c(c1)CCC21NC(=O)N(CC(=O)N(Cc2ccccc2)[C@@H](C)C2CC2)C1=O |
| E3 Binder | CHEMBL5083262 | ChEMBL | 7.16 | — | — | CNC(=O)Nc1ccc2c(c1)CCC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O |
| E3 Binder | CHEMBL5077158 | ChEMBL | 7.85 | — | — | CNC(=O)Nc1ccc2c(c1)CCC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O |
| E3 Binder | CHEMBL4282264 | ChEMBL | 7.21 | 6TF | — | CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N(Cc2ccc(F)cc2)[C@@H](C)C(F)(F)F)C1=O |
| E3 Binder | CHEMBL4174931 | ChEMBL | 7.22 | — | — | CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N(Cc2ccccc2)[C@@H](C)C(F)(F)F)C1=O |
| E3 Binder | CHEMBL4166626 | ChEMBL | 7.6 | — | — | CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N(Cc2ccccc2)[C@@H](C)C2CC2)C1=O |
| E3 Binder | CHEMBL4170186 | ChEMBL | 7.5 | — | — | CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N(Cc2ccccc2)[C@H](C2CC2)C(F)(F)F)C1=O |
| E3 Binder | CHEMBL5082755 | ChEMBL | 8.15 | — | — | CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)c(F)cc3CC[C@H]2C2CC2)C1=O |
| E3 Binder | CHEMBL5090239 | ChEMBL | 8.15 | — | — | CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O |
| E3 Binder | CHEMBL4475351 | ChEMBL | 8.09 | — | — | CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O |
| E3 Binder | CHEMBL4524352 | ChEMBL | 7.55 | — | — | CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C)C1=O |
| E3 Binder | CHEMBL5085891 | ChEMBL | 7.36 | — | — | CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cccnc3CC[C@H]2C2CC2)C1=O |
| E3 Binder | CHEMBL5078021 | ChEMBL | 7.55 | — | — | CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccncc3CC[C@H]2C2CC2)C1=O |
| E3 Binder | CHEMBL5084035 | ChEMBL | 7.39 | — | — | CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cnccc3CC[C@H]2C2CC2)C1=O |
| E3 Binder | CHEMBL5078353 | ChEMBL | 7.52 | — | — | CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ncccc3CC[C@H]2C2CC2)C1=O |
| E3 Binder | CHEMBL5089370 | ChEMBL | 6.17 | — | — | CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3sc(C)c(C)c3OC[C@H]2C(F)(F)F)C1=O |
| E3 Binder | CHEMBL5094423 | ChEMBL | 7.92 | — | — | CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3sccc3OC[C@H]2C2CC2)C1=O |
| E3 Binder | CHEMBL4163183 | ChEMBL | 6.77 | — | — | CNC(=O)Nc1ccc2c(c1)CC[C@]21NC(=O)N(CC(=O)N(Cc2ccccc2)[C@@H](C)C2CC2)C1=O |
| E3 Binder | CHEMBL4754103 | ChEMBL | 8.52 | — | — | CNC(=O)Nc1ccc2c(c1)CC[C@]21OC(=O)N(CC(=O)N(Cc2ccc(F)cc2)[C@@H](C)C(F)(F)F)C1=O |
| E3 Binder | CHEMBL4177251 | ChEMBL | 6.92 | — | — | CNC(=O)Nc1ccc2c(c1)CC[C@]21OC(=O)N(CC(=O)N(Cc2ccccc2)[C@@H](C)C2CC2)C1=O |
| E3 Binder | CHEMBL5073432 | ChEMBL | 7.29 | — | — | CNC(=O)Nc1ccc2c(c1)COC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O |
| E3 Binder | CHEMBL5081689 | ChEMBL | 7.66 | — | — | CNC(=O)Nc1ccc2c(c1)OCC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O |
| E3 Binder | CHEMBL4061254 | ChEMBL | 8.66 | — | — | CNC(=O)c1c[nH]c2c(C(C)C)nc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)cc12 |
| E3 Binder | CHEMBL4073812 | ChEMBL | 8.3 | — | — | CNC(=O)c1c[nH]c2cnc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)cc12 |
| E3 Binder | CHEMBL4208820 | ChEMBL | 9.64 | — | — | CNC(=O)c1ccc(-c2cc3cccc(-c4nn(C5CCOCC5)c5c4CN(C(C)=O)CC5)c3cn2)cn1 |
| E3 Binder | CHEMBL5221030 | ChEMBL | 6.5 | — | — | CNC(=O)c1ccc(NC(=O)[C@H]2CCCN2C(=O)C2(c3cccc(Cl)c3)CCCC2)cc1 |
| E3 Binder | CHEMBL3915504 | ChEMBL | 7.16 | — | — | CNC(=O)c1cccc(Nc2nn(CC3CC3)c3c2CN(C(C)=O)CC3)c1 |
| E3 Binder | CHEMBL4176737 | ChEMBL | 6.0 | — | — | COC(=O)Nc1ccc2c(c1)CCC21NC(=O)N(CC(=O)N(Cc2ccccc2)[C@@H](C)C2CC2)C1=O |
| E3 Binder | CHEMBL3926801 | ChEMBL | 6.85 | — | — | COC(=O)c1ccc(Nc2n[nH]c3c2CN(C(C)=O)CC3)cc1 |
| E3 Binder | CHEMBL3907779 | ChEMBL | 6.96 | — | — | COC(=O)c1cccc(Nc2n[nH]c3c2CN(C(C)=O)CC3)c1 |
| E3 Binder | CHEMBL3919629 | ChEMBL | 6.64 | — | — | COCCn1nc(Nc2cccc(C)c2)c2c1CCN(C(C)=O)C2 |
| E3 Binder | CHEMBL4171228 | ChEMBL | 6.28 | 8FV | — | COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccnc4ccccc34)c12 |
| E3 Binder | CHEMBL4173488 | ChEMBL | 7.33 | EO4 | — | COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C4CC4)nn3C)c12 |
| E3 Binder | CHEMBL5220447 | ChEMBL | 7.1 | — | — | COc1ccc(C2(C(=O)N3CCC[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCC2)cc1 |
| E3 Binder | CHEMBL5193672 | ChEMBL | 7.4 | 6YI | — | COc1ccc(C2(C(=O)N3CS(=O)(=O)C[C@@H]3C(=O)Nc3cccc4[nH]ncc34)CCCC2)cc1 |
| E3 Binder | CHEMBL3622373 | ChEMBL | 7.68 | 2LO | — | COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2C[C@H](C)N2CCOCC2)cc1Cl |
| E3 Binder | CHEMBL4867046 | ChEMBL | 6.8 | — | — | COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC2CCCCC2)cc1 |
| E3 Binder | CHEMBL4853072 | ChEMBL | 7.14 | — | — | COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC2CCCCC2)cc1Cl |
| E3 Binder | CHEMBL5285272 | ChEMBL | 7.68 | — | — | COc1ccc(CCc2nc3ccc(-c4c(C)noc4C)cc3n2C[C@H](C)N2CCOCC2)cc1Cl |
| E3 Binder | CHEMBL5219466 | ChEMBL | 6.3 | — | — | COc1ccc(NC(=O)[C@H]2CCCN2C(=O)C2(c3cccc(Cl)c3)CCCC2)nc1 |
| E3 Binder | CHEMBL5089448 | ChEMBL | 7.0 | OSN | — | COc1ccc2c(c1)N(CCC/C=C/c1cccc3c1N[C@H](C)CC(=O)N3)CCC2 |
| E3 Binder | CHEMBL4163872 | ChEMBL | 6.8 | — | — | COc1ccc2c(c1)c(C(=O)Nc1cc(C(=O)O)cc(-c3cnn(C)c3)c1)cn2C(C)=O |
| E3 Binder | CHEMBL4171749 | ChEMBL | 7.43 | EJ3 | — | COc1ccc2c(c1)c(C(=O)Nc1cc(C(=O)O)cc(-c3cnn(C)c3)c1F)cn2C(C)=O |
| E3 Binder | CHEMBL3917847 | ChEMBL | 6.47 | — | — | COc1cccc(Nc2n[nH]c3c2CN(C(C)=O)CC3)c1 |
| E3 Binder | CHEMBL5076857 | ChEMBL | 6.5 | — | — | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O |
| E3 Binder | CHEMBL5088540 | ChEMBL | 6.65 | — | — | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O |
| E3 Binder | CHEMBL4168543 | ChEMBL | 6.29 | — | — | C[C@@H](C1CC1)N(Cc1ccccc1)C(=O)CN1C(=O)N[C@]2(CCc3ccccc32)C1=O |
| E3 Binder | CHEMBL3814752 | ChEMBL | 7.86 | 69E | — | C[C@@H]1CC(=O)Nc2cccc(-c3ccc4c(c3)c(-c3cnn(C)c3)nn4C)c2N1 |
| E3 Binder | CHEMBL4207557 | ChEMBL | 6.33 | 58N | — | C[C@@H]1CC(=O)Nc2cccc(-c3cnn(C(C)(C)C)c3)c2N1 |
| E3 Binder | CHEMBL4171897 | ChEMBL | 6.0 | — | — | C[C@H](C1CC1)N(Cc1ccccc1)C(=O)CN1C(=O)N[C@]2(CCc3ccccc32)C1=O |
| E3 Binder | CHEMBL4641354 | ChEMBL | 8.54 | QS1 | — | C[C@H](CN[C@@H](C(=O)Nc1ccc(-c2cnn(C)c2)cn1)c1ccccc1)c1ccc(C#N)cc1 |
| E3 Binder | CHEMBL5274024 | ChEMBL | 7.72 | 7OW | — | Cc1cc(-c2ccc3nc(C4CCOCC4)n(CCOC(F)(F)F)c3c2)cn(C)c1=O |
| E3 Binder | CHEMBL3926851 | ChEMBL | 6.77 | JW4 | — | Cc1ccc2ncccc2c1-c1cc(-c2c(C)noc2C)cc2nc(C3CC3)[nH]c12 |
| E3 Binder | CHEMBL3753333 | ChEMBL | 6.62 | 2LL | — | Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccccc1)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL5279037 | ChEMBL | 6.3 | — | — | Cc1noc(C)c1-c1ccc2nc(CCc3ccccc3)n(CCN(C)C)c2c1 |
| E3 Binder | CHEMBL4095153 | ChEMBL | 8.44 | — | — | Cn1cc(-c2cc3c(cc2C(F)F)N(c2cc(N4CCOCC4)c4c(c2)n(C)c(=O)n4C)CCC3)cn1 |
| E3 Binder | CHEMBL4072630 | ChEMBL | 7.7 | — | — | Cn1cc(-c2cc3c(cc2C(F)F)N(c2ccc4c(c2)n(C)c(=O)n4C)CCC3)cn1 |
| E3 Binder | CHEMBL4636118 | ChEMBL | 8.17 | QSD | — | Cn1cc(-c2ccc(NC(=O)[C@H](NCCc3ccc(C#N)cc3)c3ccccc3)nc2)cn1 |
| E3 Binder | CHEMBL4633516 | ChEMBL | 8.49 | — | — | Cn1cc(-c2ccc3c(C(=O)[C@H](NCCc4ccc(C#N)cc4)c4ccccc4)c[nH]c3c2)cn1 |
| E3 Binder | CHEMBL4441544 | ChEMBL | 7.0 | — | — | N#Cc1ccc(-c2ccc(/C=C3\SC(=S)N(CCc4ccccc4)C3=O)o2)cc1 |
| E3 Binder | CHEMBL5220732 | ChEMBL | 7.3 | — | — | N#Cc1ccc(C2(C(=O)N3CCC[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCC2)cc1 |
| E3 Binder | CHEMBL5219512 | ChEMBL | 6.6 | — | — | O=C(Nc1ccc(O)cc1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1 |
| E3 Binder | CHEMBL5219678 | ChEMBL | 6.5 | — | — | O=C(Nc1ccc2[nH]c(=O)[nH]c2c1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1 |
| E3 Binder | CHEMBL5219030 | ChEMBL | 7.3 | — | — | O=C(Nc1ccc2[nH]ccc2n1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1 |
| E3 Binder | CHEMBL5220332 | ChEMBL | 6.7 | — | — | O=C(Nc1ccc2[nH]ncc2c1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1 |
| E3 Binder | CHEMBL5220956 | ChEMBL | 7.8 | — | — | O=C(Nc1ccc2[nH]ncc2n1)[C@H]1CCCN1C(=O)C1(c2ccc(Cl)cc2)CC(F)(F)C1 |
| E3 Binder | CHEMBL5221053 | ChEMBL | 7.4 | — | — | O=C(Nc1ccc2[nH]ncc2n1)[C@H]1CCCN1C(=O)C1(c2ccc(Cl)cc2)CCC1 |
| E3 Binder | CHEMBL5219157 | ChEMBL | 7.0 | — | — | O=C(Nc1ccc2[nH]ncc2n1)[C@H]1CCCN1C(=O)C1(c2ccc(F)cc2)CCC1 |
| E3 Binder | CHEMBL5219693 | ChEMBL | 7.9 | — | — | O=C(Nc1ccc2[nH]ncc2n1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1 |
| E3 Binder | CHEMBL5219177 | ChEMBL | 8.1 | — | — | O=C(Nc1ccc2[nH]ncc2n1)[C@H]1COCCN1C(=O)C1(c2ccc(Cl)cc2)CC(F)(F)C1 |
| E3 Binder | CHEMBL5220994 | ChEMBL | 8.5 | — | — | O=C(Nc1ccc2[nH]ncc2n1)[C@H]1C[C@@H](F)CN1C(=O)C1(c2ccc(Cl)cc2)CC(F)(F)C1 |
| E3 Binder | CHEMBL5219667 | ChEMBL | 8.2 | — | — | O=C(Nc1ccc2[nH]ncc2n1)[C@H]1C[C@@H](F)CN1C(=O)C1(c2ccc(Cl)cc2)CCC1 |
| E3 Binder | CHEMBL5220546 | ChEMBL | 6.3 | — | — | O=C1Cc2cc(NC(=O)[C@H]3CCCN3C(=O)C3(c4cccc(Cl)c4)CCCC3)ccc2N1 |
| E3 Binder | CHEMBL4088793 | ChEMBL | 9.0 | — | — | CC(=O)N1CCC(n2nc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)c3c2CCN(C(C)=O)C3)CC1 |
| E3 Binder | CHEMBL4086422 | ChEMBL | 6.35 | — | — | CC(=O)N1CCCc2cc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)ccc21 |
| E3 Binder | CHEMBL4207080 | ChEMBL | 7.37 | — | — | CC(=O)N1CCc2c(c(-c3c[nH]c4ccccc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4217633 | ChEMBL | 6.19 | — | — | CC(=O)N1CCc2c(c(-c3cc(C#N)cc4ccncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4203862 | ChEMBL | 7.24 | — | — | CC(=O)N1CCc2c(c(-c3cc(C)cc4ccncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4210701 | ChEMBL | 7.16 | — | — | CC(=O)N1CCc2c(c(-c3cc(CO)cc4ccncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4207560 | ChEMBL | 6.77 | — | — | CC(=O)N1CCc2c(c(-c3cc(Cl)cc4ccncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4210092 | ChEMBL | 6.55 | — | — | CC(=O)N1CCc2c(c(-c3ccc(C#N)c4ccncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4215166 | ChEMBL | 7.89 | — | — | CC(=O)N1CCc2c(c(-c3ccc(C)c4ccncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4214660 | ChEMBL | 7.19 | — | — | CC(=O)N1CCc2c(c(-c3ccc(CO)c4ccncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4214949 | ChEMBL | 7.05 | — | — | CC(=O)N1CCc2c(c(-c3ccc(Cl)c4ccncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4210763 | ChEMBL | 6.92 | — | — | CC(=O)N1CCc2c(c(-c3cccc4[nH]ccc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4207043 | ChEMBL | 7.51 | BKD | — | CC(=O)N1CCc2c(c(-c3cccc4[nH]ccc34)nn2CC2CC2)C1 |
| E3 Binder | CHEMBL4215949 | ChEMBL | 6.75 | — | — | CC(=O)N1CCc2c(c(-c3cccc4c(C#N)cncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4210047 | ChEMBL | 7.09 | — | — | CC(=O)N1CCc2c(c(-c3cccc4c(CO)cncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4208936 | ChEMBL | 7.38 | — | — | CC(=O)N1CCc2c(c(-c3cccc4c(Cl)cncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4204263 | ChEMBL | 7.09 | — | — | CC(=O)N1CCc2c(c(-c3cccc4c3CC(=O)NC4)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4218809 | ChEMBL | 7.1 | — | — | CC(=O)N1CCc2c(c(-c3cccc4c[nH]c(=O)cc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4218138 | ChEMBL | 7.52 | — | — | CC(=O)N1CCc2c(c(-c3cccc4ccncc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4216533 | ChEMBL | 6.62 | — | — | CC(=O)N1CCc2c(c(-c3ccccc3)nn2CC2CC2)C1 |
| E3 Binder | CHEMBL4206026 | ChEMBL | 6.89 | — | — | CC(=O)N1CCc2c(c(-c3ccnc4ccccc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4203693 | ChEMBL | 7.05 | — | — | CC(=O)N1CCc2c(c(-c3cncc4ccccc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4202407 | ChEMBL | 6.72 | — | — | CC(=O)N1CCc2c(c(-c3nccc4ccccc34)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4083416 | ChEMBL | 8.82 | — | — | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)(F)F)cc43)nn2[C@H]2CCOC2)C1 |
| E3 Binder | CHEMBL4091202 | ChEMBL | 8.51 | — | — | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCCCC2)C1 |
| E3 Binder | CHEMBL4098938 | ChEMBL | 8.7 | — | — | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCN(C)CC2)C1 |
| E3 Binder | CHEMBL4060566 | ChEMBL | 8.92 | — | — | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCN(S(C)(=O)=O)CC2)C1 |
| E3 Binder | CHEMBL4080905 | ChEMBL | 8.82 | — | — | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCNCC2)C1 |
| E3 Binder | CHEMBL4061161 | ChEMBL | 8.92 | — | — | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCS(=O)(=O)CC2)C1 |
| E3 Binder | CHEMBL4061600 | ChEMBL | 8.85 | 9UA | — | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2[C@H]2CCOC2)C1 |
| E3 Binder | CHEMBL4062259 | ChEMBL | 8.36 | — | — | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C)cc43)nn2[C@H]2CCOC2)C1 |
| E3 Binder | CHEMBL4099857 | ChEMBL | 8.37 | — | — | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(Cl)cc43)nn2[C@H]2CCOC2)C1 |
| E3 Binder | CHEMBL4077449 | ChEMBL | 7.8 | 9U7 | — | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)ccc43)nn2[C@H]2CCOC2)C1 |
| E3 Binder | CHEMBL4095660 | ChEMBL | 7.51 | — | — | CC(=O)N1CCc2c(c(N3CCc4cc(-c5cnn(C)c5)ccc43)nn2[C@H]2CCOC2)C1 |
| E3 Binder | CHEMBL3897393 | ChEMBL | 7.7 | 6XH | — | CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C)c4)cc3F)nn2[C@H]2CCOC2)C1 |
| E3 Binder | CHEMBL4215879 | ChEMBL | 6.82 | — | — | CC(=O)N1CCc2c(c(Nc3ccccc3)nn2CC2CC2)C1 |
| E3 Binder | CHEMBL4077375 | ChEMBL | 6.27 | — | — | CC(=O)N1CCc2c(cc(-c3cccc(Cl)c3)c(=O)n2CC2CC2)C1 |
| E3 Binder | CHEMBL4097991 | ChEMBL | 7.33 | — | — | CC(=O)N1CCc2c(cc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)c(=O)n2C)C1 |
| E3 Binder | CHEMBL4085966 | ChEMBL | 6.7 | — | — | CC(=O)Nc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 |
| E3 Binder | CHEMBL5204688 | ChEMBL | 8.83 | — | — | CC(=O)c1cc(C(=O)Nc2cc(C(C)O)cc(-c3cnn(C4CC4)c3)c2F)c2cc(N)ccn12 |
| E3 Binder | CHEMBL5192554 | ChEMBL | 7.1 | — | — | CC(=O)c1cc(C(=O)Nc2cc(C(C)O)cc(-c3cnn(C4CC4)c3)c2F)c2cc(O)ccn12 |
| E3 Binder | CHEMBL5208356 | ChEMBL | 7.58 | — | — | CC(=O)c1cc(C(=O)Nc2cc(C(C)O)cc(-c3cnn(C4CC4)c3)c2F)c2cc(OC(=O)N(C)C)ccn12 |
| E3 Binder | CHEMBL5191527 | ChEMBL | 7.86 | — | — | CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C)c3)c2F)c2cc(C)ccn12 |
| E3 Binder | CHEMBL5204233 | ChEMBL | 7.25 | — | — | CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C)c3)c2F)c2cc(CN)ccn12 |
| E3 Binder | CHEMBL5191045 | ChEMBL | 8.72 | — | — | CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C)c3)c2F)c2cc(N)ccn12 |
| E3 Binder | CHEMBL5192405 | ChEMBL | 7.58 | — | — | CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C)c3)c2F)c2cc(O)ccn12 |
| E3 Binder | CHEMBL5200678 | ChEMBL | 7.38 | — | — | CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C)c3)c2F)c2cc(OC(=O)C(C)(C)C)ccn12 |
| E3 Binder | CHEMBL5179809 | ChEMBL | 8.53 | — | — | CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C4CC4)c3)c2F)c2cc(N)ccn12 |
| E3 Binder | CHEMBL5198835 | ChEMBL | 7.61 | — | — | CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C4CC4)c3)c2F)c2cc(O)ccn12 |
| E3 Binder | CHEMBL5192803 | ChEMBL | 7.67 | JE9 | — | CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C4CC4)c3)c2F)c2cc(OC(=O)N(C)C)ccn12 |
| E3 Binder | CHEMBL4174306 | ChEMBL | 6.0 | — | — | CC(=O)n1cc(C(=O)Nc2cc(C(=O)O)cc(-c3ccc4c(cnn4C)c3)c2)c2ccccc21 |
| E3 Binder | CHEMBL4165995 | ChEMBL | 6.77 | — | — | CC(=O)n1cc(C(=O)Nc2cc(C(=O)O)cc(-c3ccco3)c2)c2cc(O)ccc21 |
| E3 Binder | CHEMBL4172241 | ChEMBL | 6.11 | — | — | CC(=O)n1cc(C(=O)Nc2cc(C(=O)O)ccc2F)c2ccccc21 |
| E3 Binder | CHEMBL4169942 | ChEMBL | 6.0 | — | — | CC(=O)n1cc(C(=O)Nc2cc(COC3CCCCO3)cc(C(=O)O)c2)c2ccccc21 |
| E3 Binder | CHEMBL3650893 | ChEMBL | 6.35 | — | — | CC(C)n1cc2c(n1)C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 |
| E3 Binder | CHEMBL3815023 | ChEMBL | 6.8 | — | — | CC(c1ccccc1)n1cc(-c2cccc3c2N[C@H](C)CC(=O)N3)cn1 |
| E3 Binder | CHEMBL3906203 | ChEMBL | 6.49 | — | — | CCC(=O)N1CCOc2c(cc(-c3ccc(OC)c(OC)c3)cc2OCC2CCCN(C)C2)C1 |
| E3 Binder | CHEMBL5181127 | ChEMBL | 7.11 | — | — | CCC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C)c3)c2F)c2cc(O)ccn12 |
| E3 Binder | CHEMBL4085329 | ChEMBL | 6.16 | — | — | CCCCCOc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 |
| E3 Binder | CHEMBL4063726 | ChEMBL | 6.58 | — | — | CCCCOc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 |
| E3 Binder | CHEMBL3963965 | ChEMBL | 6.89 | KJS | — | CCCOc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 |
| E3 Binder | CHEMBL4875619 | ChEMBL | 6.2 | — | — | CCCOc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC2CCCCC2)cc1 |
| E3 Binder | CHEMBL4758202 | ChEMBL | 6.11 | — | — | CCN(CC)CCCC(C)NCc1nn2c(-c3ccccc3)nnc2s1 |
| E3 Binder | CHEMBL4080528 | ChEMBL | 7.51 | — | — | CCNC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL1621052 | ChEMBL | 6.64 | — | — | CCOC(=O)c1cnc2ccc(C(=O)OC)cc2c1Nc1cccc(C(=O)O)c1 |
| E3 Binder | CHEMBL4207490 | ChEMBL | 7.4 | E3T | — | CCOc1ccc(C(C)=O)cc1-c1cc(NC(=O)c2ccco2)cc(-c2c(C)noc2C)c1 |
| E3 Binder | CHEMBL4203144 | ChEMBL | 6.85 | E2T | — | CCOc1ccc(C(C)=O)cc1-c1cc(NC(=O)c2ccco2)cc(-c2c(C)on(C)c2=O)c1 |
| E3 Binder | CHEMBL4202606 | ChEMBL | 6.84 | E3H | — | CCOc1ccc(C(C)=O)cc1-c1cc(NC(=O)c2ccco2)cc(-c2c(C)on(CC)c2=O)c1 |
| E3 Binder | CHEMBL4206032 | ChEMBL | 7.23 | YE5 | — | CCOc1ccc(C(C)=O)cc1-c1cccc(-c2nn[nH]n2)c1 |
| E3 Binder | CHEMBL4210443 | ChEMBL | 8.52 | 0BC | — | CCOc1ccc(C(C)=O)cc1NC(=O)c1cc(-c2cscn2)cc(-c2nn[nH]n2)c1 |
| E3 Binder | CHEMBL3770598 | ChEMBL | 6.77 | — | — | CCOc1ccc(C(C)=O)cc1NC(=O)c1cc(C(=O)O)cc(-c2ccoc2)c1 |
| E3 Binder | CHEMBL3771341 | ChEMBL | 6.28 | — | — | CCOc1ccc(C(C)=O)cc1NC(=O)c1cc(COC)cc(C(=O)O)c1 |
| E3 Binder | CHEMBL3770322 | ChEMBL | 6.43 | — | — | CCOc1ccc(C(C)=O)cc1NC(=O)c1cc(COC2CCCCO2)cc(C(=O)O)c1 |
| E3 Binder | CHEMBL4205572 | ChEMBL | 7.72 | 92E | — | CCOc1ccc(C(C)=O)cc1NC(=O)c1cc(NC(C)=O)cc(NC(=O)c2ccco2)c1 |
| E3 Binder | CHEMBL3770150 | ChEMBL | 6.17 | UL4 | — | CCOc1ccc(C(C)=O)cc1NC(=O)c1cccc(C(=O)O)c1 |
| E3 Binder | CHEMBL3769500 | ChEMBL | 6.31 | — | — | CCOc1ccc(C(C)=O)cc1NC(=O)c1cccc(C(=O)OC)c1 |
| E3 Binder | CHEMBL4206088 | ChEMBL | 6.01 | — | — | CCOc1ccc(C(C)=O)cc1Nc1ccc2c(c1)N(S(C)(=O)=O)CC2 |
| E3 Binder | CHEMBL4066476 | ChEMBL | 6.89 | — | — | CCOc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 |
| E3 Binder | CHEMBL4859434 | ChEMBL | 6.67 | — | — | CCOc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC2CCCCC2)cc1 |
| E3 Binder | CHEMBL3813915 | ChEMBL | 6.21 | — | — | CC[C@@H](NC(=O)c1cccc2c1N[C@H](C)CC(=O)N2)c1cnco1 |
| E3 Binder | CHEMBL3650917 | ChEMBL | 6.02 | — | — | CCc1c2c(nn1C1CC1)C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 |
| E3 Binder | CHEMBL4214979 | ChEMBL | 7.62 | — | — | CCc1cc(-c2nn(C3CCOCC3)c3c2CN(C(C)=O)CC3)c2cnccc2c1 |
| E3 Binder | CHEMBL4209747 | ChEMBL | 7.51 | — | — | CCc1ccc(-c2nn(C3CCOCC3)c3c2CN(C(C)=O)CC3)c2cnccc12 |
| E3 Binder | CHEMBL5195875 | ChEMBL | 7.66 | — | — | CCc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(CO)cc(-c4cnn(C)c4)c3F)c2c1 |
| E3 Binder | CHEMBL4213692 | ChEMBL | 7.42 | — | — | CCc1cncc2c(-c3nn(C4CCOCC4)c4c3CN(C(C)=O)CC4)cccc12 |
| E3 Binder | CHEMBL4078019 | ChEMBL | 6.51 | — | — | CCc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccccc1)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4068497 | ChEMBL | 6.3 | — | — | CCn1cc(-c2ccc3c(c2)nc(CCc2ccccc2)n3CCN2CCOCC2)ccc1=O |
| E3 Binder | CHEMBL3654293 | ChEMBL | 6.2 | — | — | CCn1nc(C)c2c1C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1F |
| E3 Binder | CHEMBL4104751 | ChEMBL | 6.51 | — | — | CN(C)C(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1 |
| E3 Binder | CHEMBL4095016 | ChEMBL | 7.42 | — | — | CN1C(=O)CCc2ccc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)cc21 |
| E3 Binder | CHEMBL4795699 | ChEMBL | 7.71 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4cc[nH]n4)cc3)cc21 |
| E3 Binder | CHEMBL4776036 | ChEMBL | 6.71 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc21 |
| E3 Binder | CHEMBL4755792 | ChEMBL | 6.99 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4ccccn4)cc3)cc21 |
| E3 Binder | CHEMBL4779896 | ChEMBL | 7.27 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4cccnc4)cc3)cc21 |
| E3 Binder | CHEMBL4776578 | ChEMBL | 7.28 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4ccn(C(C)=O)n4)cc3)cc21 |
| E3 Binder | CHEMBL4741233 | ChEMBL | 7.4 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4ccn(C)n4)cc3)cc21 |
| E3 Binder | CHEMBL4784945 | ChEMBL | 7.13 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4ccn(S(C)(=O)=O)n4)cc3)cc21 |
| E3 Binder | CHEMBL4756910 | ChEMBL | 7.05 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4ccncc4)cc3)cc21 |
| E3 Binder | CHEMBL4791519 | ChEMBL | 7.32 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4cn[nH]c4)cc3)cc21 |
| E3 Binder | CHEMBL4778341 | ChEMBL | 7.07 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4cnn(C(C)=O)c4)cc3)cc21 |
| E3 Binder | CHEMBL4790542 | ChEMBL | 7.43 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4cnn(C)c4)cc3)cc21 |
| E3 Binder | CHEMBL4791402 | ChEMBL | 7.03 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4cnn(S(C)(=O)=O)c4)cc3)cc21 |
| E3 Binder | CHEMBL4792407 | ChEMBL | 7.03 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4cc[nH]n4)c3)cc21 |
| E3 Binder | CHEMBL4783911 | ChEMBL | 6.99 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4ccn(C(C)=O)n4)c3)cc21 |
| E3 Binder | CHEMBL4793642 | ChEMBL | 7.34 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4ccn(C)n4)c3)cc21 |
| E3 Binder | CHEMBL4740324 | ChEMBL | 7.02 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4ccn(S(C)(=O)=O)n4)c3)cc21 |
| E3 Binder | CHEMBL4758366 | ChEMBL | 7.22 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4ccncc4)c3)cc21 |
| E3 Binder | CHEMBL4743523 | ChEMBL | 7.04 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4cn[nH]c4)c3)cc21 |
| E3 Binder | CHEMBL4780426 | ChEMBL | 6.54 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4cnn(C(C)=O)c4)c3)cc21 |
| E3 Binder | CHEMBL4783664 | ChEMBL | 7.26 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4cnn(C)c4)c3)cc21 |
| E3 Binder | CHEMBL4755549 | ChEMBL | 7.12 | — | — | CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4cnn(S(C)(=O)=O)c4)c3)cc21 |
| E3 Binder | CHEMBL4076254 | ChEMBL | 7.89 | — | — | CNC(=O)N1CCOc2ccc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)cc2C1 |
| E3 Binder | CHEMBL4068063 | ChEMBL | 6.92 | — | — | CNC(=O)Nc1cc(OC)cc(N2CCCc3cc(-c4cnn(C)c4)c(C(F)F)cc32)n1 |
| E3 Binder | CHEMBL1738935 | ChEMBL | 6.57 | YCU | — | CNC(=O)Nc1cc(OC)cc(NC(=O)NS(=O)(=O)c2cc(C)c(CCOC)s2)n1 |
| E3 Binder | CHEMBL4065346 | ChEMBL | 8.02 | C3J | — | CNC(=O)c1c[nH]c2ccc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)cc12 |
| E3 Binder | CHEMBL4059634 | ChEMBL | 7.47 | — | — | CNC(=O)c1ccc2nccc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)c2c1 |
| E3 Binder | CHEMBL5179328 | ChEMBL | 8.68 | — | — | CNc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(CO)cc(-c4cnn(C)c4)c3F)c2c1 |
| E3 Binder | CHEMBL4103593 | ChEMBL | 6.68 | 3OT | — | COc1cc(-c2ccc3c(c2)nc(CCc2ccccc2)n3CCN2CCOCC2)cccc1=O |
| E3 Binder | CHEMBL4215815 | ChEMBL | 7.16 | — | — | COc1cc(-c2nn(C3CCOCC3)c3c2CN(C(C)=O)CC3)c2cnccc2c1 |
| E3 Binder | CHEMBL3581661 | ChEMBL | 6.17 | — | — | COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C4CC4)n[nH]c3C)c12 |
| E3 Binder | CHEMBL4072979 | ChEMBL | 8.33 | — | — | COc1cc2c(cc1-c1cnn(C)c1)CCCN2c1nn([C@H]2CCOC2)c2c1CN(C(C)=O)CC2 |
| E3 Binder | CHEMBL3814246 | ChEMBL | 6.89 | — | — | COc1ccc(-c2cccc3c2N[C@H](C)CC(=O)N3)cc1OC |
| E3 Binder | CHEMBL4217552 | ChEMBL | 7.57 | — | — | COc1ccc(-c2nn(C3CCOCC3)c3c2CN(C(C)=O)CC3)c2cnccc12 |
| E3 Binder | CHEMBL4078551 | ChEMBL | 6.3 | — | — | COc1ccc(CCc2c(C#N)c3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 |
| E3 Binder | CHEMBL3752200 | ChEMBL | 7.68 | — | — | COc1ccc(CCc2cc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1F |
| E3 Binder | CHEMBL4074405 | ChEMBL | 6.77 | — | — | COc1ccc(CCc2cc3nc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 |
| E3 Binder | CHEMBL4096429 | ChEMBL | 6.62 | — | — | COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)c(OC)c1 |
| E3 Binder | CHEMBL4084580 | ChEMBL | 6.92 | — | — | COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 |
| E3 Binder | CHEMBL4754613 | ChEMBL | 7.55 | — | — | COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1Cl |
| E3 Binder | CHEMBL3753048 | ChEMBL | 7.66 | — | — | COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1F |
| E3 Binder | CHEMBL4078384 | ChEMBL | 6.33 | — | — | COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1OC |
| E3 Binder | CHEMBL4875068 | ChEMBL | 6.54 | — | — | COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC(C)C)cc1 |
| E3 Binder | CHEMBL4864701 | ChEMBL | 6.04 | — | — | COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC23CC4CC(CC(C4)C2)C3)cc1 |
| E3 Binder | CHEMBL4876541 | ChEMBL | 6.12 | — | — | COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC2CCCCC2)cc1OC |
| E3 Binder | CHEMBL4878741 | ChEMBL | 6.34 | — | — | COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NCCN2CCOCC2)cc1 |
| E3 Binder | CHEMBL4086250 | ChEMBL | 6.04 | — | — | COc1ccc(OCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 |
| E3 Binder | CHEMBL3110353 | ChEMBL | 6.1 | — | — | COc1ccc(S(=O)(=O)Nc2cc(-c3nn4c(C)nnc4c4ccccc34)ccc2N2CCN(C)CC2)cc1 |
| E3 Binder | CHEMBL5085444 | ChEMBL | 6.5 | — | — | COc1ccc2c(c1)N(CCC/C=C\c1cccc3c1N[C@H](C)CC(=O)N3)CCC2 |
| E3 Binder | CHEMBL5085843 | ChEMBL | 6.81 | — | — | COc1ccc2c(c1)N(CCCC#Cc1cccc3c1N[C@H](C)CC(=O)N3)CCC2 |
| E3 Binder | CHEMBL4790788 | ChEMBL | 6.5 | — | — | COc1ccc2c(c1)N(CCCNC(=O)c1cc(C)cc3c1N[C@H](C)C(=O)N3)CCC2 |
| E3 Binder | CHEMBL3752296 | ChEMBL | 6.5 | 2O4 | — | COc1ccc2c(c1)N(CCCNC(=O)c1cccc3c1N[C@H](C)C(=O)N3)CCC2 |
| E3 Binder | CHEMBL5076790 | ChEMBL | 6.33 | OS8 | — | COc1ccc2c(c1)N(CCCNC(=O)c1cccc3c1N[C@H](C)CC(=O)N3)CCC2 |
| E3 Binder | CHEMBL4163435 | ChEMBL | 6.16 | — | — | COc1ccc2c(c1)c(C(=O)Nc1cc(C(=O)O)cc(-c3ccc4c(c3)OCCO4)c1)cn2C(C)=O |
| E3 Binder | CHEMBL4174134 | ChEMBL | 6.54 | — | — | COc1ccc2c(c1)c(C(=O)Nc1cc(C(=O)O)cc(-c3ccc4c(cnn4C)c3)c1)cn2C(C)=O |
| E3 Binder | CHEMBL4173925 | ChEMBL | 6.85 | — | — | COc1ccc2c(c1)c(C(=O)Nc1cc(C(=O)O)cc(-c3ccco3)c1)cn2C(C)=O |
| E3 Binder | CHEMBL4075476 | ChEMBL | 6.51 | — | — | COc1cccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)c1 |
| E3 Binder | CHEMBL4070185 | ChEMBL | 6.24 | — | — | COc1cccc2c1N(CCCNC(=O)c1cccc3c1N[C@H](C)C(=O)N3)CCC2 |
| E3 Binder | CHEMBL4095141 | ChEMBL | 6.01 | — | — | COc1ccccc1CCc1nc2cc(-c3c(C)noc3C)ccc2n1CCN1CCOCC1 |
| E3 Binder | CHEMBL5205974 | ChEMBL | 8.01 | — | — | COc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(C(=O)O)cc(-c4cnn(C)c4)c3F)c2c1 |
| E3 Binder | CHEMBL5179520 | ChEMBL | 8.38 | — | — | COc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(C(C)O)cc(-c4cnn(C5CC5)c4)c3F)c2c1 |
| E3 Binder | CHEMBL5195756 | ChEMBL | 7.89 | — | — | COc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(C=O)cc(-c4cnn(C)c4)c3F)c2c1 |
| E3 Binder | CHEMBL5198394 | ChEMBL | 7.92 | — | — | COc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(CO)cc(-c4cnn(C)c4)c3F)c2c1 |
| E3 Binder | CHEMBL5207470 | ChEMBL | 7.26 | — | — | COc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(Cl)cc(-c4cnn(C)c4)c3F)c2c1 |
| E3 Binder | CHEMBL5179738 | ChEMBL | 7.16 | — | — | COc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(F)cc(-c4cnn(C)c4)c3F)c2c1 |
| E3 Binder | CHEMBL4209359 | ChEMBL | 7.64 | — | — | COc1cncc2c(-c3nn(C4CCOCC4)c4c3CN(C(C)=O)CC4)cccc12 |
| E3 Binder | CHEMBL3650905 | ChEMBL | 6.25 | — | — | COc1ncc(-n2nc3c(c2C)C(c2ccc(Cl)cc2)N(c2cc(Cl)c(=O)n(C)c2)C3=O)c(OC)n1 |
| E3 Binder | CHEMBL3814602 | ChEMBL | 6.6 | — | — | C[C@@H]1CC(=O)Nc2cccc(-c3ccc4c(c3)c(C#N)nn4C)c2N1 |
| E3 Binder | CHEMBL3813929 | ChEMBL | 7.11 | — | — | C[C@@H]1CC(=O)Nc2cccc(-c3ccc4c(c3)c(C(N)=O)nn4C)c2N1 |
| E3 Binder | CHEMBL3814550 | ChEMBL | 7.48 | 69B | — | C[C@@H]1CC(=O)Nc2cccc(-c3ccc4c(c3)c(C3CC3)nn4C)c2N1 |
| E3 Binder | CHEMBL3814197 | ChEMBL | 6.62 | — | — | C[C@@H]1CC(=O)Nc2cccc(-c3ccc4c(cnn4C)c3)c2N1 |
| E3 Binder | CHEMBL3813846 | ChEMBL | 6.96 | 69F | — | C[C@@H]1CC(=O)Nc2cccc(-c3cccc(OCc4ccccc4)c3)c2N1 |
| E3 Binder | CHEMBL4762972 | ChEMBL | 6.75 | — | — | C[C@@H]1CC(=O)Nc2cccc(/C=C/c3ccccc3S(N)(=O)=O)c2N1 |
| E3 Binder | CHEMBL3814881 | ChEMBL | 6.17 | — | — | C[C@@H]1CC(=O)Nc2cccc(C(=O)NC3CCOc4ccccc43)c2N1 |
| E3 Binder | CHEMBL3814891 | ChEMBL | 6.28 | 69A | — | C[C@@H]1CC(=O)Nc2cccc(C(=O)NCc3ccccc3)c2N1 |
| E3 Binder | CHEMBL3813713 | ChEMBL | 6.05 | — | — | C[C@@H]1CC(=O)Nc2cccc(C(=O)N[C@H](C)c3ccccc3)c2N1 |
| E3 Binder | CHEMBL3814896 | ChEMBL | 7.41 | — | — | C[C@@H]1CC(=O)Nc2cccc(C(=O)Nc3cccc(-c4cnco4)c3)c2N1 |
| E3 Binder | CHEMBL4068116 | ChEMBL | 8.47 | — | — | C[C@@H]1CC(=O)Nc2cccc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)c2N1 |
| E3 Binder | CHEMBL4216748 | ChEMBL | 6.12 | 2O3 | — | C[C@H]1Nc2c(cccc2C(=O)NCCCN2CCCc3ccccc32)NC1=O |
| E3 Binder | CHEMBL4064118 | ChEMBL | 7.21 | — | — | C[C@H]1Nc2c(cccc2N2CCCc3cc(-c4cnn(C)c4)c(C(F)F)cc32)NC1=O |
| E3 Binder | CHEMBL5274107 | ChEMBL | 6.82 | — | — | C[C@H]1[C@H]2N(C(=O)CN(C)N2C(=O)NCc2ccccc2)[C@@H](Cc2ccc(OP(=O)(O)O)cc2)C(=O)N1Cc1cccc2cccnc12 |
| E3 Binder | CHEMBL4063051 | ChEMBL | 6.0 | 87P | — | Cc1[nH]c(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)c2c1C(=O)CCC2 |
| E3 Binder | CHEMBL3786012 | ChEMBL | 6.0 | — | — | Cc1[nH]c(-c2cc(S(C)(=O)=O)ccc2Oc2ccc(F)cc2F)c2c1C(=O)NCC2 |
| E3 Binder | CHEMBL3650914 | ChEMBL | 6.38 | — | — | Cc1c2c(nn1C(C)C)C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 |
| E3 Binder | CHEMBL1370704 | ChEMBL | 6.36 | — | — | Cc1cc(C)c2c(=O)n(CC(=O)Nc3ccc(Cl)cc3)sc2n1 |
| E3 Binder | CHEMBL3650913 | ChEMBL | 6.4 | — | — | Cc1cc(N2C(=O)c3nn(C(C)C)c(C)c3C2c2ccc(Cl)cc2)cn(C)c1=O |
| E3 Binder | CHEMBL3650892 | ChEMBL | 6.42 | — | — | Cc1cc(N2C(=O)c3nn(C(C)C)cc3C2c2ccc(Cl)cc2)cn(C)c1=O |
| E3 Binder | CHEMBL3650894 | ChEMBL | 6.18 | — | — | Cc1cc(N2C(=O)c3nn(C4CC4)c(C(F)(F)F)c3C2c2ccc(Cl)cc2)cn(C)c1=O |
| E3 Binder | CHEMBL4751783 | ChEMBL | 6.12 | — | — | Cc1cc2c(c(C(=O)NCCCN3CCCc4ccccc43)c1)N[C@H](C)C(=O)N2 |
| E3 Binder | CHEMBL3650929 | ChEMBL | 6.04 | — | — | Cc1ncccc1-n1nc2c(c1C)C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O |
| E3 Binder | CHEMBL3650940 | ChEMBL | 6.19 | — | — | Cc1nn(C2CCC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O |
| E3 Binder | CHEMBL3108803 | ChEMBL | 6.2 | — | — | Cc1nnc2c3ccccc3c(-c3ccc(N4CCOCC4)c(NS(=O)(=O)c4ccc(Cl)cc4)c3)nn12 |
| E3 Binder | CHEMBL3108801 | ChEMBL | 6.7 | Y1Z | — | Cc1nnc2c3ccccc3c(-c3ccc(N4CCOCC4)c(NS(=O)(=O)c4ccccc4Cl)c3)nn12 |
| E3 Binder | CHEMBL3108800 | ChEMBL | 6.2 | — | — | Cc1nnc2c3ccccc3c(-c3ccc(N4CCOCC4)c(NS(C)(=O)=O)c3)nn12 |
| E3 Binder | CHEMBL2335154 | ChEMBL | 6.11 | 1H3 | — | Cc1noc(C)c1-c1cc(O)cc([C@@H](O)c2ccccc2)c1 |
| E3 Binder | CHEMBL4101368 | ChEMBL | 6.89 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc(-c1cnn3c1CCC3)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4068021 | ChEMBL | 6.13 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1c[nH]c3ccccc13)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4065507 | ChEMBL | 6.52 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccc(C#N)cc1)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4071814 | ChEMBL | 6.19 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccc(CCCN(C)C)cc1)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4094643 | ChEMBL | 6.68 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccc(N(C)C)cc1)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4074125 | ChEMBL | 7.05 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccc(N)cc1)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4094017 | ChEMBL | 6.62 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccc(O)cc1)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4075074 | ChEMBL | 6.7 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccc(OC(C)C)cc1)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4210853 | ChEMBL | 6.19 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccc(OCCCN(C)C)cc1)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4063290 | ChEMBL | 6.8 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccc3ccccc3n1)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4074676 | ChEMBL | 6.44 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccccc1)n2CC(=O)N1CCOCC1 |
| E3 Binder | CHEMBL3775371 | ChEMBL | 7.68 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccccc1)n2C[C@H](C)N1CCOCC1 |
| E3 Binder | CHEMBL4064489 | ChEMBL | 6.48 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccccn1)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4092184 | ChEMBL | 6.11 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1cccnc1)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4077279 | ChEMBL | 6.4 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccncc1)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4104158 | ChEMBL | 6.4 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc(COc1ccccc1)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4066064 | ChEMBL | 7.12 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc([C@@H]1CCO[C@H]1c1ccccc1)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4093638 | ChEMBL | 6.85 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc([C@H]1CCO[C@@H]1c1ccccc1)n2CCN1CCOCC1 |
| E3 Binder | CHEMBL4085900 | ChEMBL | 6.35 | — | — | Cc1noc(C)c1-c1ccc2c(c1)nc1n2[C@H](CN2CCOCC2)C[C@@H]1Cc1ccccc1 |
| E3 Binder | CHEMBL4848135 | ChEMBL | 6.02 | — | — | Cc1noc(C)c1-c1ccn2c(NC(C)(C)C)c(CCc3ccccc3)nc2c1 |
| E3 Binder | CHEMBL4878894 | ChEMBL | 6.29 | — | — | Cc1noc(C)c1-c1ccn2c(NC34CC5CC(CC(C5)C3)C4)c(CCc3ccccc3)nc2c1 |
| E3 Binder | CHEMBL4848215 | ChEMBL | 6.14 | — | — | Cc1noc(C)c1-c1ccn2c(NC3CCCCC3)c(CCc3ccccc3)nc2c1 |
| E3 Binder | CHEMBL4081585 | ChEMBL | 7.16 | C3V | — | Cn1cc(-c2cc3c(cc2C(F)F)N(c2ccc4sc(=O)n(C)c4c2)CCC3)cn1 |
| E3 Binder | CHEMBL4069831 | ChEMBL | 9.0 | — | — | Cn1cc(-c2cc3c(cc2C(F)F)N(c2nn(C4CCOCC4)c4c2CN(C(N)=O)CC4)CCC3)cn1 |
| E3 Binder | CHEMBL3650891 | ChEMBL | 6.13 | — | — | Cn1cc(N2C(=O)c3nn(C4CC4)c(C(F)(F)F)c3C2c2ccc(Cl)cc2)cc(Cl)c1=O |
| E3 Binder | CHEMBL3650889 | ChEMBL | 6.02 | — | — | Cn1cc(N2C(=O)c3nn(C4CC4)cc3C2c2ccc(Cl)cc2)cc(Cl)c1=O |