REQU

Details:

UniProt Entry: Q92785
Gene: DPF2
Class: RING
Family: RING1
Protein length: 391
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 3iuf, 5b79, 5vdc, 6lth, 6ltj

Protein Sequence ▾

>Q92785
MAAVVENVVK LLGEQYYKDA MEQCHNYNAR LCAERSVRLP FLDSQTGVAQ SNCYIWMEKR
HRGPGLASGQ LYSYPARRWR KKRRAHPPED PRLSFPSIKP DTDQTLKKEG LISQDGSSLE
ALLRTDPLEK RGAPDPRVDD DSLGEFPVTN SRARKRILEP DDFLDDLDDE DYEEDTPKRR
GKGKSKGKGV GSARKKLDAS ILEDRDKPYA CDICGKRYKN RPGLSYHYAH SHLAEEEGED
KEDSQPPTPV SQRSEEQKSK KGPDGLALPN NYCDFCLGDS KINKKTGQPE ELVSCSDCGR
SGHPSCLQFT PVMMAAVKTY RWQCIECKCC NICGTSENDD QLLFCDDCDR GYHMYCLTPS
MSEPPEGSWS CHLCLDLLKE KASIYQNQNS S

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
14	84	Domain	DPF1-3, N-terminal domain	IPR025750	PF14051
205	233	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
209	237	Domain	Zinc finger C2H2-type	IPR013087	PS50157
209	232	Domain	Zinc finger C2H2-type	IPR013087	SM00355
211	232	Domain	Zinc finger C2H2-type	IPR013087	PS00028
266	328	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
268	391	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
270	330	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
272	328	Domain	Zinc finger, PHD-type	IPR001965	SM00249
313	380	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
327	377	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
329	375	Domain	Zinc finger, PHD-type	IPR001965	SM00249
330	374	Domain	Zinc finger, PHD-finger	IPR019787	PF00628

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	TAS	PMID:28533407
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0006338	chromatin remodeling	Biological Process	NAS	PMID:10078207
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	NAS	PMID:18809673
GO:0007399	nervous system development	Biological Process	IBA	GO_REF:0000033
GO:0030071	regulation of mitotic metaphase/anaphase transition	Biological Process	NAS	PMID:25066234
GO:0070316	regulation of G0 to G1 transition	Biological Process	NAS	PMID:11790558
GO:0097190	apoptotic signaling pathway	Biological Process	TAS	PMID:7961935
GO:1902459	positive regulation of stem cell population maintenance	Biological Process	NAS	PMID:19279220
GO:1905454	negative regulation of myeloid progenitor cell differentiation	Biological Process	IMP	PMID:28533407
GO:2000045	regulation of G1/S transition of mitotic cell cycle	Biological Process	NAS	PMID:10778858
GO:2000781	positive regulation of double-strand break repair	Biological Process	NAS	PMID:25066234
GO:2000819	regulation of nucleotide-excision repair	Biological Process	NAS	PMID:12215535
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005813	centrosome	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0000785	chromatin	Cellular Component	NAS	PMID:12192000
GO:0016514	SWI/SNF complex	Cellular Component	NAS	PMID:8804307
GO:0071565	nBAF complex	Cellular Component	IBA	GO_REF:0000033
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0062072	histone H3K9me2/3 reader activity	Molecular Function	IDA	PMID:29429572
GO:0003714	transcription corepressor activity	Molecular Function	TAS	PMID:28533407
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0140015	histone H3K14ac reader activity	Molecular Function	IDA	PMID:28533407
GO:0140046	histone H4K16ac reader activity	Molecular Function	IDA	PMID:28533407

Enzyme–Substrate Interactions ▾

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