KLHL6

Details:

UniProt Entry: Q8WZ60
Gene: KLHL6
Class: Other E3 Components
Family: Adaptor
Protein length: 621
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8WZ60
MLMAGQRGAW TMGDVVEKSL EGPLAPSTDE PSQKTGDLVE ILNGEKVKFD DAGLSLILQN
GLETLRMENA LTDVILCVDI QEFSCHRVVL AAASNYFRAM FCNDLKEKYE KRIIIKGVDA
ETMHTLLDYT YTSKALITKQ NVQRVLEAAN LFQFLRMVDA CASFLTEALN PENCVGILRL
ADTHSLDSLK KQVQSYIIQN FVQILNSEEF LDLPVDTLHH ILKSDDLYVT EEAQVFETVM
SWVRHKPSER LCLLPYVLEN VRLPLLDPWY FVETVEADPL IRQCPEVFPL LQEARMYHLS
GNEIISERTK PRMHEFQSEV FMIIGGCTKD ERFVAEVTCL DPLRRSRLEV AKLPLTEHEL
ESENKKWVEF ACVTLKNEVY ISGGKETQHD VWKYNSSINK WIQIEYLNIG RWRHKMVVLG
GKVYVIGGFD GLQRINNVET YDPFHNCWSE AAPLLVHVSS FAATSHKKKL YVIGGGPNGK
LATDKTQCYD PSTNKWSLKA AMPVEAKCIN AVSFRDRIYV VGGAMRALYA YSPLEDSWCL
VTQLSHERAS CGIAPCNNRL YITGGRDEKN EVIATVLCWD PEAQKLTEEC VLPRGVSHHG
SVTIRKSYTH IRRIVPGAVS V

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
32	611	Family	BTB-kelch protein	IPR017096	PIRSF037037
48	176	Domain	Kelch-like protein 6, BTB/POZ domain	IPR029851	cd18236
55	167	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
55	197	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
63	167	Domain	BTB/POZ domain	IPR000210	PF00651
72	139	Domain	BTB/POZ domain	IPR000210	PS50097
72	169	Domain	BTB/POZ domain	IPR000210	SM00225
174	276	Domain	BTB/Kelch-associated	IPR011705	SM00875
174	276	Domain	BTB/Kelch-associated	IPR011705	PF07707
304	605	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
319	603	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
378	421	Repeat	Kelch repeat type 1	IPR006652	SM00612
414	454	Repeat	Kelch repeat type 1	IPR006652	PF01344
422	468	Repeat	Kelch repeat type 1	IPR006652	SM00612
459	503	Repeat	Kelch repeat type 1	IPR006652	PF01344
469	516	Repeat	Kelch repeat type 1	IPR006652	SM00612
517	558	Repeat	Kelch repeat type 1	IPR006652	SM00612
548	584	Repeat	Kelch repeat type 1	IPR006652	PF01344
559	606	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0002467	germinal center formation	Biological Process	IEA	GO_REF:0000002
GO:0050853	B cell receptor signaling pathway	Biological Process	IEA	GO_REF:0000002
GO:0009617	response to bacterium	Biological Process	IEA	GO_REF:0000107
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:25036637
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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