BACD1

Details:

UniProt Entry: Q8WZ19
Gene: KCTD13
Class: Other E3 Components
Family: Adaptor
Protein length: 329
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8WZ19
MSAEASGPAA AAAPSLEAPK PSGLEPGPAA YGLKPLTPNS KYVKLNVGGS LHYTTLRTLT
GQDTMLKAMF SGRVEVLTDA GGWVLIDRSG RHFGTILNYL RDGSVPLPES TRELGELLGE
ARYYLVQGLI EDCQLALQQK RETLSPLCLI PMVTSPREEQ QLLASTSKPV VKLLHNRSNN
KYSYTSTSDD NLLKNIELFD KLALRFHGRL LFLKDVLGDE ICCWSFYGQG RKIAEVCCTS
IVYATEKKQT KVEFPEARIF EETLNILIYE TPRGPDPALL EATGGAAGAG GAGRGEDEEN
REHRVRRIHV RRHITHDERP HGQQIVFKD

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
36	143	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
37	288	Family	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1/2/3	IPR045068	PTHR11145
41	109	Domain	BTB/POZ domain	IPR000210	PS50097
41	136	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
41	141	Domain	BTB/POZ domain	IPR000210	SM00225
43	133	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0061351	neural precursor cell proliferation	Biological Process	ISS	GO_REF:0000024
GO:0016477	cell migration	Biological Process	IMP	PMID:19782033
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0035024	negative regulation of Rho protein signal transduction	Biological Process	ISS	GO_REF:0000024
GO:0043149	stress fiber assembly	Biological Process	IMP	PMID:19782033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0045740	positive regulation of DNA replication	Biological Process	IEA	GO_REF:0000120
GO:0050806	positive regulation of synaptic transmission	Biological Process	ISS	GO_REF:0000024
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-9696266
GO:0016604	nuclear body	Cellular Component	IDA	GO_REF:0000052
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0019904	protein domain specific binding	Molecular Function	IEA	GO_REF:0000120
GO:0031267	small GTPase binding	Molecular Function	IDA	PMID:19782033
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000107

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.