MYLIP

Details:

UniProt Entry: Q8WY64
Gene: MYLIP
Class: RING
Family: RING3
Protein length: 445
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 2yhn, 2yho, 6qly, 6qlz

Protein Sequence ▾

>Q8WY64
MLCYVTRPDA VLMEVEVEAK ANGEDCLNQV CRRLGIIEVD YFGLQFTGSK GESLWLNLRN
RISQQMDGLA PYRLKLRVKF FVEPHLILQE QTRHIFFLHI KEALLAGHLL CSPEQAVELS
ALLAQTKFGD YNQNTAKYNY EELCAKELSS ATLNSIVAKH KELEGTSQAS AEYQVLQIVS
AMENYGIEWH SVRDSEGQKL LIGVGPEGIS ICKDDFSPIN RIAYPVVQMA TQSGKNVYLT
VTKESGNSIV LLFKMISTRA ASGLYRAITE THAFYRCDTV TSAVMMQYSR DLKGHLASLF
LNENINLGKK YVFDIKRTSK EVYDHARRAL YNAGVVDLVS RNNQSPSHSP LKSSESSMNC
SSCEGLSCQQ TRVLQEKLRK LKEAMLCMVC CEEEINSTFC PCGHTVCCES CAAQLQSCPV
CRSRVEHVQH VYLPTHTSLL NLTVI

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	83	Homologous_superfamily	Ubiquitin-like domain superfamily	IPR029071	SSF54236
1	190	Domain	Band 4.1 domain	IPR019749	SM00295
1	279	Domain	FERM domain	IPR000299	PS50057
5	67	Domain	FERM, N-terminal	IPR018979	PF09379
14	33	Family	Ezrin/radixin/moesin-like	IPR000798	PR00661
34	46	Domain	Band 4.1 domain	IPR019749	PR00935
65	84	Family	Ezrin/radixin/moesin-like	IPR000798	PR00661
80	182	Homologous_superfamily	FERM/acyl-CoA-binding protein superfamily	IPR014352	G3DSA:1.20.80.10
84	180	Homologous_superfamily	FERM superfamily, second domain	IPR035963	SSF47031
84	190	Domain	FERM central domain	IPR019748	PF00373
92	180	Domain	FERM central domain	IPR019748	cd14473
98	111	Domain	Band 4.1 domain	IPR019749	PR00935
107	128	Family	Ezrin/radixin/moesin-like	IPR000798	PR00661
111	131	Domain	Band 4.1 domain	IPR019749	PR00935
170	186	Domain	Band 4.1 domain	IPR019749	PR00935
185	295	Domain	MYLIP, FERM domain C-lobe	IPR041790	cd13195
185	278	Homologous_superfamily	PH-like domain superfamily	IPR011993	G3DSA:2.30.29.30
193	213	Family	Ezrin/radixin/moesin-like	IPR000798	PR00661
194	283	Domain	FERM, C-terminal PH-like domain	IPR018980	SM01196
367	445	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
387	422	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0007399	nervous system development	Biological Process	IMP	PMID:10593918
GO:0010977	negative regulation of neuron projection development	Biological Process	IMP	PMID:10593918
GO:0010989	negative regulation of low-density lipoprotein particle clearance	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0031648	protein destabilization	Biological Process	IEA	GO_REF:0000107
GO:0032803	regulation of low-density lipoprotein particle receptor catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0042632	cholesterol homeostasis	Biological Process	IEA	GO_REF:0000107
GO:0045732	positive regulation of protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8854628
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:12826659
GO:0008092	cytoskeletal protein binding	Molecular Function	IEA	GO_REF:0000002
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾


Q8WY64	MYLIP	Yes	Yes	No	Yes	12826659	EBI-10919757	E3-specific
P98155	VLDLR	Yes	Yes	No	No	—	No	E3-specific
P01130	LDLR	Yes	Yes	No	No	—	No	E3-specific
Q14114	LRP8	Yes	Yes	No	No	—	No	E3-specific

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q8WY64	MYLIP	Yes	Yes	No	Yes	12826659	EBI-10919757	E3-specific
P98155	VLDLR	Yes	Yes	No	No	—	No	E3-specific
P01130	LDLR	Yes	Yes	No	No	—	No	E3-specific
Q14114	LRP8	Yes	Yes	No	No	—	No	E3-specific