RB40A

Details:

UniProt Entry: Q8WXH6
Gene: RAB40A
Class: Other E3 Components
Family: Receptor
Protein length: 277
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8WXH6
MSAPGSPDQA YDFLLKFLLV GDRDVGKSEI LESLQDGAAE SPYSHLGGID YKTTTILLDG
QRVKLKLWDT SGQGRFCTIF RSYSRGAQGV ILVYDIANRW SFEGMDRWIK KIEEHAPGVP
KILVGNRLHL AFKRQVPREQ AQAYAERLGV TFFEVSPLCN FNIIESFTEL ARIVLLRHRM
NWLGRPSKVL SLQDLCCRTI VSCTPVHLVD KLPLPSTLRS HLKSFSMAKG LNARMMRGLS
YSLTTSSTHK SSLCKVEIVC PPQSPPKNCT RNSCKIS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	236	Family	Small GTPase	IPR001806	PS51421
6	187	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	G3DSA:3.40.50.300
10	183	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
16	156	Domain	Small GTP-binding protein domain	IPR005225	TIGR00231
16	174	Family	Small GTPase	IPR001806	PF00071
17	177	Family	Small GTPase	IPR001806	SM00174
175	228	Domain	SOCS box domain	IPR001496	PS50225
183	226	Domain	SOCS box domain	IPR001496	SM00253
189	225	Domain	SOCS box domain	IPR001496	SM00969
189	223	Domain	SOCS box domain	IPR001496	PF07525
189	227	Homologous_superfamily	SOCS box-like domain superfamily	IPR036036	SSF158235

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006887	exocytosis	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0035556	intracellular signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:26598620
GO:0120184	negative regulation of focal adhesion disassembly	Biological Process	IMP	PMID:26598620
GO:0005794	Golgi apparatus	Cellular Component	IDA	PMID:34469730
GO:0005811	lipid droplet	Cellular Component	IDA	PMID:34469730
GO:0005768	endosome	Cellular Component	IBA	GO_REF:0000033
GO:0005886	plasma membrane	Cellular Component	IBA	GO_REF:0000033
GO:0008021	synaptic vesicle	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0031466	Cul5-RING ubiquitin ligase complex	Cellular Component	IMP	PMID:26598620
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0003924	GTPase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005525	GTP binding	Molecular Function	IEA	GO_REF:0000120
GO:0016787	hydrolase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IMP	PMID:26598620

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.