SOCS4

Details:

UniProt Entry: Q8WXH5
Gene: SOCS4
Class: Other E3 Components
Family: Receptor
Protein length: 440
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8WXH5
MAENNENISK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESYSDAE TVNGIEKTEV
SLRNQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSGLPSKR
KIHISELMLD KCPFPPRSDL AFRWHFIKRH TAPINSKSDE WVSTDLSQTE LRDGQLKRRN
MEENINCFSH TNVQPCVITT DNALCREGPM TGSVMNLVSN NSIEDSDMDS DDEILTLCTS
SRKRNKPKWD LDDEILQLET PPKYHTQIDY VHCLVPDLLQ INNNPCYWGV MDKYAAEALL
EGKPEGTFLL RDSAQEDYLF SVSFRRYSRS LHARIEQWNH NFSFDAHDPC VFHSPDITGL
LEHYKDPSAC MFFEPLLSTP LIRTFPFSLQ HICRTVICNC TTYDGIDALP IPSSMKLYLK
EYHYKSKVRV LRIDAPEQQC

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
58	110	Domain	SOCS4/SOCS5 domain	IPR022252	PF12610
267	437	Homologous_superfamily	SH2 domain superfamily	IPR036860	G3DSA:3.30.505.10
275	383	Homologous_superfamily	SH2 domain superfamily	IPR036860	SSF55550
275	375	Domain	SOCS4, SH2 domain	IPR035864	cd10385
284	370	Domain	SH2 domain	IPR000980	SM00252
286	381	Domain	SH2 domain	IPR000980	PS50001
287	341	Domain	SH2 domain	IPR000980	PF00017
376	425	Domain	SOCS box domain	IPR001496	PS50225
380	423	Domain	SOCS box domain	IPR001496	SM00253
384	439	Domain	SOCS4, SOCS box domain	IPR037342	cd03738
386	422	Domain	SOCS box domain	IPR001496	SM00969
386	420	Domain	SOCS box domain	IPR001496	PF07525
387	427	Homologous_superfamily	SOCS box-like domain superfamily	IPR036036	SSF158235

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	Biological Process	IDA	PMID:15590694
GO:0009968	negative regulation of signal transduction	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0019221	cytokine-mediated signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0035556	intracellular signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:25814554

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