ZNRF4

Details:

UniProt Entry: Q8WWF5
Gene: ZNRF4
Class: RING
Family: RING3
Protein length: 429
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q8WWF5
MPLCRPEHLM PRASRVPVAA SLPLSHAVIP TQLPSRPGHR PPGRPRRCPK ASCLPPPVGP
SSTQTAKRVT MGWPRPGRAL VAVKALLVLS LLQVPAQAVV RAVLEDNSSS VDFADLPALF
GVPLAPEGIR GYLMEVKPAN ACHPIEAPRL GNRSLGAIVL IRRYDCTFDL KVLNAQRAGF
EAAIVHNVHS DDLVSMTHVY EDLRGQIAIP SVFVSEAASQ DLRVILGCNK SAHALLLPDD
PPCHDLGCHP VLTVSWVLGC TLALVVSAFF VLNHLWLWAQ ACCSHRRPVK TSTCQKAQVR
TFTWHNDLCA ICLDEYEEGD QLKILPCSHT YHCKCIDPWF SQAPRRSCPV CKQSVAATED
SFDSTTYSFR DEDPSLPGHR PPIWAIQVQL RSRRLELLGR ASPHCHCSTT SLEAEYTTVS
SAPPEAPGQ

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
86	244	Domain	ZNRF4 /RNF13/RNF167, PA domain	IPR044744	cd02123
155	199	Homologous_superfamily	PA domain superfamily	IPR046450	SSF52025
155	222	Domain	PA domain	IPR003137	PF02225
298	368	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
308	352	Domain	Zinc finger, RING-type	IPR001841	PF13639
309	351	Domain	Zinc finger, RING-type	IPR001841	SM00184
309	352	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0042742	defense response to bacterium	Biological Process	IDA	PMID:16824733
GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	Biological Process	IDA	PMID:16824733
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:28656966
GO:0045786	negative regulation of cell cycle	Biological Process	IBA	GO_REF:0000033
GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	Biological Process	IDA	PMID:28656966
GO:1902532	negative regulation of intracellular signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005783	endoplasmic reticulum	Cellular Component	IDA	PMID:28656966
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IDA	PMID:28656966
GO:0012505	endomembrane system	Cellular Component	IEA	GO_REF:0000117
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0031090	organelle membrane	Cellular Component	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:21205830
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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