KBTB7

Details:

UniProt Entry: Q8WVZ9
Gene: KBTBD7
Class: Other E3 Components
Family: Adaptor
Protein length: 684
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8WVZ9
MQSREDVPRS RRLASPRGGR RPKRISKPSV SAFFTGPEEL KDTAHSAALL AQLKSFYDAR
LLCDVTIEVV TPGSGPGTGR LFSCNRNVLA AACPYFKSMF TGGMYESQQA SVTMHDVDAE
SFEVLVDYCY TGRVSLSEAN VQRLYAASDM LQLEYVREAC ASFLARRLDL TNCTAILKFA
DAFDHHKLRS QAQSYIAHNF KQLSRMGSIR EETLADLTLA QLLAVLRLDS LDIESERTVC
HVAVQWLEAA AKERGPSAAE VFKCVRWMHF TEEDQDYLEG LLTKPIVKKY CLDVIEGALQ
MRYGDLLYKS LVPVPNSSSS SSSSNSLVSA AENPPQRLGM CAKEMVIFFG HPRDPFLCYD
PYSGDIYTMP SPLTSFAHTK TVTSSAVCVS PDHDIYLAAQ PRKDLWVYKP AQNSWQQLAD
RLLCREGMDV AYLNGYIYIL GGRDPITGVK LKEVECYSVQ RNQWALVAPV PHSFYSFELI
VVQNYLYAVN SKRMLCYDPS HNMWLNCASL KRSDFQEACV FNDEIYCICD IPVMKVYNPA
RGEWRRISNI PLDSETHNYQ IVNHDQKLLL ITSTTPQWKK NRVTVYEYDT REDQWINIGT
MLGLLQFDSG FICLCARVYP SCLEPGQSFI TEEDDARSES STEWDLDGFS ELDSESGSSS
SFSDDEVWVQ VAPQRNAQDQ QGSL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
26	619	Family	BTB-kelch protein	IPR017096	PIRSF037037
37	169	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
42	166	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
54	166	Domain	BTB/POZ domain	IPR000210	PF00651
63	168	Domain	BTB/POZ domain	IPR000210	SM00225
63	138	Domain	BTB/POZ domain	IPR000210	PS50097
173	273	Domain	BTB/Kelch-associated	IPR011705	PF07707
173	279	Domain	BTB/Kelch-associated	IPR011705	SM00875
331	623	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
345	603	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
394	435	Repeat	Kelch repeat type 1	IPR006652	SM00612
429	469	Repeat	Kelch repeat type 1	IPR006652	PF01344
436	484	Repeat	Kelch repeat type 1	IPR006652	SM00612
663	674	Conserved_site	KBTB, W-type LIR motif	IPR046790	PF20165

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0009968	negative regulation of signal transduction	Biological Process	IEA	GO_REF:0000043
GO:0035020	regulation of Rac protein signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0070936	protein K48-linked ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000117
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:16169070
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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