RN138

Details:

UniProt Entry: Q8WVD3
Gene: RNF138
Class: RING
Family: RING4
Protein length: 245
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q8WVD3
MAEDLSAATS YTEDDFYCPV CQEVLKTPVR TTACQHVFCR KCFLTAMRES GAHCPLCRGN
VTRRERACPE RALDLENIMR KFSGSCRCCA KQIKFYRMRH HYKSCKKYQD EYGVSSIIPN
FQISQDSVGN SNRSETSTSD NTETYQENTS SSGHPTFKCP LCQESNFTRQ RLLDHCNSNH
LFQIVPVTCP ICVSLPWGDP SQITRNFVSH LNQRHQFDYG EFVNLQLDEE TQYQTAVEES
FQVNI

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
4	112	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
18	58	Domain	Zinc finger, RING-type	IPR001841	PS50089
18	57	Domain	Zinc finger, RING-type	IPR001841	SM00184
80	112	Domain	Zinc finger C2HC RNF-type	IPR034734	PF18574
86	105	Domain	Zinc finger C2HC RNF-type	IPR034734	PS51803
156	216	Domain	Drought induced 19 protein type, zinc-binding domain	IPR008598	PF05605
159	192	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0016055	Wnt signaling pathway	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:1990830	cellular response to leukemia inhibitory factor	Biological Process	IEA	GO_REF:0000107
GO:0000724	double-strand break repair via homologous recombination	Biological Process	IBA	GO_REF:0000033
GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing	Biological Process	IBA	GO_REF:0000033
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0035861	site of double-strand break	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	HDA	PMID:21630459
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0003697	single-stranded DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:19549727
GO:0019901	protein kinase binding	Molecular Function	IPI	PMID:16714285

Enzyme–Substrate Interactions ▾


Q8WVD3	RN138	Yes	Yes	No	No	—	No	E3-specific
Q9UJU2	LEF1	Yes	Yes	No	No	—	No	E3-specific
Q9NQB0	TF7L2	Yes	Yes	No	No	—	No	E3-specific

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q8WVD3	RN138	Yes	Yes	No	No	—	No	E3-specific
Q9UJU2	LEF1	Yes	Yes	No	No	—	No	E3-specific
Q9NQB0	TF7L2	Yes	Yes	No	No	—	No	E3-specific