TRI41

Details:

UniProt Entry: Q8WV44
Gene: TRIM41
Class: RING
Family: RING5
Protein length: 630
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2egm

Protein Sequence ▾

>Q8WV44
MAAVAMTPNP VQTLQEEAVC AICLDYFTDP VSIGCGHNFC RVCVTQLWGG EDEEDRDELD
REEEEEDGEE EEVEAVGAGA GWDTPMRDED YEGDMEEEVE EEEEGVFWTS GMSRSSWDNM
DYVWEEEDEE EDLDYYLGDM EEEDLRGEDE EDEEEVLEEV EEEDLDPVTP LPPPPAPRRC
FTCPQCRKSF PRRSFRPNLQ LANMVQVIRQ MHPTPGRGSR VTDQGICPKH QEALKLFCEV
DEEAICVVCR ESRSHKQHSV VPLEEVVQEY KAKLQGHVEP LRKHLEAVQK MKAKEERRVT
ELKSQMKSEL AAVASEFGRL TRFLAEEQAG LERRLREMHE AQLGRAGAAA SRLAEQAAQL
SRLLAEAQER SQQGGLRLLQ DIKETFNRCE EVQLQPPEVW SPDPCQPHSH DFLTDAIVRK
MSRMFCQAAR VDLTLDPDTA HPALMLSPDR RGVRLAERRQ EVADHPKRFS ADCCVLGAQG
FRSGRHYWEV EVGGRRGWAV GAARESTHHK EKVGPGGSSV GSGDASSSRH HHRRRRLHLP
QQPLLQREVW CVGTNGKRYQ AQSSTEQTLL SPSEKPRRFG VYLDYEAGRL GFYNAETLAH
VHTFSAAFLG ERVFPFFRVL SKGTRIKLCP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
5	78	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
20	186	Domain	Zinc finger, RING-type	IPR001841	SM00184
20	61	Domain	Zinc finger, RING-type	IPR001841	PS50089
35	44	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
222	263	Domain	B-box-type zinc finger	IPR000315	PS50119
222	263	Domain	B-box-type zinc finger	IPR000315	SM00336
224	263	Domain	B-box-type zinc finger	IPR000315	PF00643
413	630	Domain	B30.2/SPRY domain	IPR001870	PS50188
423	630	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
428	627	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
429	446	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
430	482	Domain	SPRY-associated	IPR006574	SM00589
432	630	Domain	TRIM41, PRY/SPRY domain	IPR042828	cd13741
433	481	Domain	SPRY-associated	IPR006574	PF13765
446	463	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
468	492	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
483	630	Domain	SPRY domain	IPR003877	SM00449
485	620	Domain	SPRY domain	IPR003877	PF00622
570	594	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
601	619	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006513	protein monoubiquitination	Biological Process	IDA	PMID:29760876
GO:0009967	positive regulation of signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0051607	defense response to virus	Biological Process	IEA	GO_REF:0000117
GO:0060340	positive regulation of type I interferon-mediated signaling pathway	Biological Process	IDA	PMID:29760876
GO:0071222	cellular response to lipopolysaccharide	Biological Process	IMP	PMID:27812135
GO:0071225	cellular response to muramyl dipeptide	Biological Process	IMP	PMID:27812135
GO:0001650	fibrillar center	Cellular Component	IDA	GO_REF:0000052
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:22493164
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


Q9Y5A6	ZSC21	Yes	No	Yes	No	25416956	EBI-10328749	Cluster-specific
Q8N884	CGAS	Yes	No	No	No	—	No	E3-specific
Q02156	KPCE	Yes	Yes	No	No	—	No	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q9Y5A6	ZSC21	Yes	No	Yes	No	25416956	EBI-10328749	Cluster-specific
Q8N884	CGAS	Yes	No	No	No	—	No	E3-specific
Q02156	KPCE	Yes	Yes	No	No	—	No	E3-specific