NSE1

Details:

UniProt Entry: Q8WV22
Gene: NSMCE1
Class: RING
Family: RING4
Protein length: 266
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2ct0, 5hvq, 5wy5

Protein Sequence ▾

>Q8WV22
MQGSTRRMGV MTDVHRRFLQ LLMTHGVLEE WDVKRLQTHC YKVHDRNATV DKLEDFINNI
NSVLESLYIE IKRGVTEDDG RPIYALVNLA TTSISKMATD FAENELDLFR KALELIIDSE
TGFASSTNIL NLVDQLKGKK MRKKEAEQVL QKFVQNKWLI EKEGEFTLHG RAILEMEQYI
RETYPDAVKI CNICHSLLIQ GQSCETCGIR MHLPCVAKYF QSNAEPRCPH CNDYWPHEIP
KVFDPEKERE SGVLKSNKKS LRSRQH

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
10	250	Family	Non-structural maintenance of chromosomes element 1	IPR011513	PTHR20973
15	176	Family	Non-structural maintenance of chromosomes element 1	IPR011513	PF07574
91	188	Homologous_superfamily	Winged helix-like DNA-binding domain superfamily	IPR036388	G3DSA:1.10.10.10
176	228	Domain	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	IPR002219	PS50081
189	246	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
190	234	Domain	Non-structural maintenance of chromosomes element 1, RING C4HC3-type	IPR014857	cd16493
191	232	Domain	Zinc finger, RING-type	IPR001841	PS50089
191	231	Domain	Non-structural maintenance of chromosomes element 1, RING C4HC3-type	IPR014857	PF08746

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000120
GO:0006310	DNA recombination	Biological Process	IEA	GO_REF:0000043
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0000724	double-strand break repair via homologous recombination	Biological Process	IBA	GO_REF:0000033
GO:0016925	protein sumoylation	Biological Process	NAS	PMID:32389690
GO:0032204	regulation of telomere maintenance	Biological Process	NAS	PMID:17589526
GO:0140588	chromatin looping	Biological Process	NAS	PMID:32389690
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0030915	Smc5-Smc6 complex	Cellular Component	IEA	GO_REF:0000120
GO:0000781	chromosome, telomeric region	Cellular Component	IEA	GO_REF:0000120
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000043
GO:0000775	chromosome, centromeric region	Cellular Component	IEA	GO_REF:0000107
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0097431	mitotic spindle pole	Cellular Component	IEA	GO_REF:0000107
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:14701739
GO:0046983	protein dimerization activity	Molecular Function	IDA	PMID:27427983

Enzyme–Substrate Interactions ▾

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