RN139

Details:

UniProt Entry: Q8WU17
Gene: RNF139
Class: RING
Family: RING7
Protein length: 664
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q8WU17
MAAVGPPQQQ VRMAHQQVWA ALEVALRVPC LYIIDAIFNS YPDSSQSRFC IVLQIFLRLF
GVFASSIVLI LSQRSLFKFY TYSSAFLLAA TSVLVNYYAS LHIDFYGAYN TSAFGIELLP
RKGPSLWMAL IVLQLTFGIG YVTLLQIHSI YSQLIILDLL VPVIGLITEL PLHIRETLLF
TSSLILTLNT VFVLAVKLKW FYYSTRYVYL LVRHMYRIYG LQLLMEDTWK RIRFPDILRV
FWLTRVTAQA TVLMYILRMA NETDSFFISW DDFWDLICNL IISGCDSTLT VLGMSAVISS
VAHYLGLGIL AFIGSTEEDD RRLGFVAPVL FFILALQTGL SGLRPEERLI RLSRNMCLLL
TAVLHFIHGM TDPVLMSLSA SHVSSFRRHF PVLFVSACLF ILPVLLSYVL WHHYALNTWL
FAVTAFCVEL CLKVIVSLTV YTLFMIDGYY NVLWEKLDDY VYYVRSTGSI IEFIFGVVMF
GNGAYTMMFE SGSKIRAFMM CLHAYFNIYL QAKNGWKTFM NRRTAVKKIN SLPEIKGSRL
QEINDVCAIC YHEFTTSARI TPCNHYFHAL CLRKWLYIQD TCPMCHQKVY IEDDIKDNSN
VSNNNGFIPP NETPEEAVRE AAAESDRELN EDDSTDCDDD VQRERNGVIQ HTGAAAEEFN
DDTD

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
20	516	Domain	TRC8-like, N-terminal domain	IPR025754	PF13705
521	599	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
546	586	Domain	Zinc finger, RING-CH-type	IPR011016	SM00744
546	585	Domain	Zinc finger, RING-type	IPR001841	PF13639
547	586	Domain	Zinc finger, RING-type	IPR001841	PS50089
547	585	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0008285	negative regulation of cell population proliferation	Biological Process	IDA	PMID:17016439
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0017148	negative regulation of translation	Biological Process	IDA	PMID:20068067
GO:0031648	protein destabilization	Biological Process	IMP	PMID:25239945
GO:0036503	ERAD pathway	Biological Process	IBA	GO_REF:0000033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0060628	regulation of ER to Golgi vesicle-mediated transport	Biological Process	IDA	PMID:19706601
GO:0070613	regulation of protein processing	Biological Process	IDA	PMID:19706601
GO:1904380	endoplasmic reticulum mannose trimming	Biological Process	TAS	Reactome:R-HSA-901032
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:25239945
GO:0012505	endomembrane system	Cellular Component	IBA	GO_REF:0000033
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000120
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0044322	endoplasmic reticulum quality control compartment	Cellular Component	IEA	GO_REF:0000108
GO:0036513	Derlin-1 retrotranslocation complex	Cellular Component	IBA	GO_REF:0000033
GO:0002020	protease binding	Molecular Function	IPI	PMID:25239945
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:17016439
GO:0005515	protein binding	Molecular Function	IPI	PMID:12032852
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019787	ubiquitin-like protein transferase activity	Molecular Function	IDA	PMID:17016439
GO:0038023	signaling receptor activity	Molecular Function	TAS	PMID:9689122
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q8WU17	RN139	Yes	No	No	No	—	No	E3-specific

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