UBP33

Details:

UniProt Entry: Q8TEY7
Gene: USP33
Class: RING
Family: RING7
Protein length: 942
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 2uzg

Protein Sequence ▾

>Q8TEY7
MTGSNSHITI LTLKVLPHFE SLGKQEKIPN KMSAFRNHCP HLDSVGEITK EDLIQKSLGT
CQDCKVQGPN LWACLENRCS YVGCGESQVD HSTIHSQETK HYLTVNLTTL RVWCYACSKE
VFLDRKLGTQ PSLPHVRQPH QIQENSVQDF KIPSNTTLKT PLVAVFDDLD IEADEEDELR
ARGLTGLKNI GNTCYMNAAL QALSNCPPLT QFFLDCGGLA RTDKKPAICK SYLKLMTELW
HKSRPGSVVP TTLFQGIKTV NPTFRGYSQQ DAQEFLRCLM DLLHEELKEQ VMEVEEDPQT
ITTEETMEED KSQSDVDFQS CESCSNSDRA ENENGSRCFS EDNNETTMLI QDDENNSEMS
KDWQKEKMCN KINKVNSEGE FDKDRDSISE TVDLNNQETV KVQIHSRASE YITDVHSNDL
STPQILPSNE GVNPRLSASP PKSGNLWPGL APPHKKAQSA SPKRKKQHKK YRSVISDIFD
GTIISSVQCL TCDRVSVTLE TFQDLSLPIP GKEDLAKLHS SSHPTSIVKA GSCGEAYAPQ
GWIAFFMEYV KRFVVSCVPS WFWGPVVTLQ DCLAAFFARD ELKGDNMYSC EKCKKLRNGV
KFCKVQNFPE ILCIHLKRFR HELMFSTKIS THVSFPLEGL DLQPFLAKDS PAQIVTYDLL
SVICHHGTAS SGHYIAYCRN NLNNLWYEFD DQSVTEVSES TVQNAEAYVL FYRKSSEEAQ
KERRRISNLL NIMEPSLLQF YISRQWLNKF KTFAEPGPIS NNDFLCIHGG VPPRKAGYIE
DLVLMLPQNI WDNLYSRYGG GPAVNHLYIC HTCQIEAEKI EKRRKTELEI FIRLNRAFQK
EDSPATFYCI SMQWFREWES FVKGKDGDPP GPIDNTKIAV TKCGNVMLRQ GADSGQISEE
TWNFLQSIYG GGPEVILRPP VVHVDPDILQ AEEKIEVETR SL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
34	130	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
37	140	Domain	Zinc finger, UBP-type	IPR001607	PS50271
60	112	Domain	Zinc finger, UBP-type	IPR001607	SM00290
61	122	Domain	Zinc finger, UBP-type	IPR001607	PF02148
181	714	Homologous_superfamily	Papain-like cysteine peptidase superfamily	IPR038765	SSF54001
185	715	Domain	Ubiquitin specific protease domain	IPR028889	PS50235
185	712	Domain	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	IPR001394	PF00443
186	201	Conserved_site	Ubiquitin specific protease, conserved site	IPR018200	PS00972
657	674	Conserved_site	Ubiquitin specific protease, conserved site	IPR018200	PS00973
711	811	Homologous_superfamily	DUSP-like superfamily	IPR035927	SSF143791
714	817	Homologous_superfamily	DUSP-like superfamily	IPR035927	G3DSA:3.30.2230.10
717	810	Domain	Peptidase C19, ubiquitin-specific peptidase, DUSP domain	IPR006615	PS51283
732	815	Domain	Peptidase C19, ubiquitin-specific peptidase, DUSP domain	IPR006615	SM00695
740	809	Domain	Peptidase C19, ubiquitin-specific peptidase, DUSP domain	IPR006615	PF06337
807	918	Homologous_superfamily	DUSP-like superfamily	IPR035927	SSF143791
818	937	Homologous_superfamily	DUSP-like superfamily	IPR035927	G3DSA:3.30.2230.10
818	921	Domain	Peptidase C19, ubiquitin-specific peptidase, DUSP domain	IPR006615	PS51283
840	924	Domain	Peptidase C19, ubiquitin-specific peptidase, DUSP domain	IPR006615	SM00695
847	916	Domain	Peptidase C19, ubiquitin-specific peptidase, DUSP domain	IPR006615	PF06337

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006508	proteolysis	Biological Process	IEA	GO_REF:0000043
GO:0006897	endocytosis	Biological Process	IEA	GO_REF:0000043
GO:0016579	protein deubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	TAS	PMID:11739384
GO:0007399	nervous system development	Biological Process	IBA	GO_REF:0000033
GO:0007411	axon guidance	Biological Process	ISS	GO_REF:0000024
GO:0008277	regulation of G protein-coupled receptor signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0016477	cell migration	Biological Process	ISS	GO_REF:0000024
GO:0050821	protein stabilization	Biological Process	IMP	PMID:23486064
GO:0051298	centrosome duplication	Biological Process	IMP	PMID:23486064
GO:0070536	protein K63-linked deubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0071108	protein K48-linked deubiquitination	Biological Process	IEA	GO_REF:0000117
GO:2000786	positive regulation of autophagosome assembly	Biological Process	IMP	PMID:24056301
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005794	Golgi apparatus	Cellular Component	IDA	GO_REF:0000052
GO:0005925	focal adhesion	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005813	centrosome	Cellular Component	IEA	GO_REF:0000044
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-5696945
GO:0043025	neuronal cell body	Cellular Component	IEA	GO_REF:0000107
GO:0030891	VCB complex	Cellular Component	TAS	PMID:11739384
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0004843	cysteine-type deubiquitinase activity	Molecular Function	IEA	GO_REF:0000120
GO:0008233	peptidase activity	Molecular Function	IEA	GO_REF:0000043
GO:0008234	cysteine-type peptidase activity	Molecular Function	IEA	GO_REF:0000043
GO:0016787	hydrolase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0043130	ubiquitin binding	Molecular Function	IDA	PMID:17766394
GO:0001664	G protein-coupled receptor binding	Molecular Function	IPI	PMID:19424180
GO:0004197	cysteine-type endopeptidase activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:11739384
GO:0031267	small GTPase binding	Molecular Function	IPI	PMID:24056301

Enzyme–Substrate Interactions ▾

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