SH3R3

Details:

UniProt Entry: Q8TEJ3
Gene: SH3RF3
Class: RING
Family: RING9
Protein length: 882
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q8TEJ3
MLLGASWLCA SKAAAAAAQS EGDEDRPGER RRRRAAATAA GAGEDMDESS LLDLLECSVC
LERLDTTAKV LPCQHTFCRR CLESIVCSRH ELRCPECRIL VGCGVDELPA NILLVRLLDG
IRQRPRAGTS PGGSPPARPI PGQSAAPTLA GGGGGAAGST PGSPVFLSAA AGSTAGSLRE
LATSRTAPAA KNPCLLPYGK ALYSYEGKEP GDLKFNKGDI IVLRRKVDEQ WYHGELHGTQ
GFLPASYIQC IQPLPHAPPQ GKALYDFEMK DKDQDKDCLT FTKDEILTVL RRVDENWAEG
MLGDKIGIFP LLYVELNDSA KQLIEMDKPC PAAASSCNAS LPSDSGAVAS VAPSPTLSSS
GAVSAFQRRV DGKKNTKKRH SFTALSVTHR SSQAASHRHS MEISAPVLIS SSDPRAAARI
GDLAHLSCAA PTQDVSSSAG STPTAVPRAA SVSGEQGTPP KVQLPLNVYL ALYAYKPQKS
DELELHKGEM YRVLEKCQDG WFKGASLRTG VSGVFPGNYV TPVSRVPAGG AGPPRNNVVG
GSPLAKGITT TMHPGSGSLS SLATATRPAL PITTPQAHAQ HPTASPPTGS CLRHSAQPTA
SQARSTISTA AHSAAQAQDR PTATVSPLRT QNSPSRLPAT SLRPHSVVSP QHSHQPPVQM
CPRPAIPLTS AASAITPPNV SAANLNGEAG GGPIGVLSTS SPTNTGCKLD EKKSEKKEKK
SGLLKLLAGA STKKKSRSPP SVSPTHDPQV AVDALLQGAV GPEVSSLSIH GRAGSCPIES
EMQGAMGMEP LHRKAGSLDL NFTSPSRQAP LSMAAIRPEP KLLPRERYRV VVSYPPQSEA
EIELKEGDIV FVHKKREDGW YKGTLQRNGR TGLFPGSFVE SF

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
44	127	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
57	98	Domain	Zinc finger, RING-type	IPR001841	PS50089
57	97	Domain	Zinc finger, RING-type	IPR001841	SM00184
57	97	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
73	82	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
194	253	Domain	SH3 domain	IPR001452	PS50002
194	259	Homologous_superfamily	SH3-like domain superfamily	IPR036028	SSF50044
197	252	Domain	SH3 domain	IPR001452	SM00326
200	245	Domain	SH3 domain	IPR001452	PF00018
255	318	Homologous_superfamily	SH3-like domain superfamily	IPR036028	SSF50044
256	319	Domain	SH3 domain	IPR001452	PS50002
259	318	Domain	SH3 domain	IPR001452	SM00326
262	310	Domain	SH3 domain	IPR001452	PF00018
459	550	Homologous_superfamily	SH3-like domain superfamily	IPR036028	SSF50044
464	525	Domain	SH3 domain	IPR001452	PS50002
467	524	Domain	SH3 domain	IPR001452	SM00326
467	523	Domain	SH3RF3, SH3 domain 3	IPR035612	cd11925
471	521	Domain	SH3 domain	IPR001452	PF14604
812	881	Homologous_superfamily	SH3-like domain superfamily	IPR036028	SSF50044
823	882	Domain	SH3 domain	IPR001452	PS50002
826	882	Domain	SH3 domain	IPR001452	SM00326
827	881	Domain	SH3RF1/SH3RF3, fourth SH3 domain	IPR035816	cd11785
830	880	Domain	SH3 domain	IPR001452	PF14604

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0046330	positive regulation of JNK cascade	Biological Process	IBA	GO_REF:0000033
GO:0051865	protein autoubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:16374509
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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