SH3R2

Details:

UniProt Entry: Q8TEC5
Gene: SH3RF2
Class: RING
Family: RING9
Protein length: 729
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q8TEC5
MDDLTLLDLL ECPVCFEKLD VTAKVLPCQH TFCKPCLQRV FKAHKELRCP ECRTPVFSNI
EALPANLLLV RLLDGVRSGQ SSGRGGSFRR PGTMTLQDGR KSRTNPRRLQ ASPFRLVPNV
RIHMDGVPRA KALCNYRGQN PGDLRFNKGD IILLRRQLDE NWYQGEINGI SGNFPASSVE
VIKQLPQPPP LCRALYNFDL RGKDKSENQD CLTFLKDDII TVISRVDENW AEGKLGDKVG
IFPILFVEPN LTARHLLEKN KGRQSSRTKN LSLVSSSSRG NTSTLRRGPG SRRKVPGQFS
ITTALNTLNR MVHSPSGRHM VEISTPVLIS SSNPSVITQP MEKADVPSSC VGQVSTYHPA
PVSPGHSTAV VSLPGSQQHL SANMFVALHS YSAHGPDELD LQKGEGVRVL GKCQDGWLRG
VSLVTGRVGI FPNNYVIPIF RKTSSFPDSR SPGLYTTWTL STSSVSSQGS ISEGDPRQSR
PFKSVFVPTA IVNPVRSTAG PGTLGQGSLR KGRSSMRKNG SLQRPLQSGI PTLVVGSLRR
SPTMVLRPQQ FQFYQPQGIP SSPSAVVVEM GSKPALTGEP ALTCISRGSE AWIHSAASSL
IMEDKEIPIK SEPLPKPPAS APPSILVKPE NSRNGIEKQV KTVRFQNYSP PPTKHYTSHP
TSGKPEQPAT LKASQPEAAS LGPEMTVLFA HRSGCHSGQQ TDLRRKSALG KATTLVSTAS
GTQTVFPSK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
3	82	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
12	52	Domain	Zinc finger, RING-type	IPR001841	SM00184
12	53	Domain	Zinc finger, RING-type	IPR001841	PS50089
12	50	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
28	37	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
124	190	Homologous_superfamily	SH3-like domain superfamily	IPR036028	SSF50044
125	184	Domain	SH3 domain	IPR001452	PS50002
128	181	Domain	E3 ubiquitin-protein ligase SH3RF2, first SH3 domain	IPR035792	cd11929
128	183	Domain	SH3 domain	IPR001452	SM00326
129	181	Domain	SH3 domain	IPR001452	PF07653
185	249	Homologous_superfamily	SH3-like domain superfamily	IPR036028	SSF50044
187	252	Domain	SH3 domain	IPR001452	PS50002
190	251	Domain	SH3 domain	IPR001452	SM00326
191	247	Domain	E3 ubiquitin-protein ligase SH3RF2, second SH3 domain	IPR035794	cd11932
207	243	Domain	SH3 domain	IPR001452	PF00018
379	458	Homologous_superfamily	SH3-like domain superfamily	IPR036028	SSF50044
380	441	Domain	SH3 domain	IPR001452	PS50002
383	393	Domain	SH3 domain	IPR001452	PR00452
383	440	Domain	SH3 domain	IPR001452	SM00326
384	438	Domain	SH3RF2, third SH3 domain	IPR035822	cd11784
387	436	Domain	SH3 domain	IPR001452	PF14604
397	412	Domain	SH3 domain	IPR001452	PR00452
427	439	Domain	SH3 domain	IPR001452	PR00452

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0043066	negative regulation of apoptotic process	Biological Process	IEA	GO_REF:0000117
GO:0046328	regulation of JNK cascade	Biological Process	IEA	GO_REF:0000117
GO:0051865	protein autoubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0030335	positive regulation of cell migration	Biological Process	IMP	PMID:24130170
GO:0031397	negative regulation of protein ubiquitination	Biological Process	IMP	PMID:24130170
GO:0046329	negative regulation of JNK cascade	Biological Process	ISS	GO_REF:0000024
GO:0046330	positive regulation of JNK cascade	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0004864	protein phosphatase inhibitor activity	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000117
GO:0008157	protein phosphatase 1 binding	Molecular Function	IBA	GO_REF:0000033
GO:0019902	phosphatase binding	Molecular Function	IDA	PMID:19389623

Enzyme–Substrate Interactions ▾

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