RN128

Details:

UniProt Entry: Q8TEB7
Gene: RNF128
Class: RING
Family: RING3
Protein length: 428
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 3icu

Protein Sequence ▾

>Q8TEB7
MGPPPGAGVS CRGGCGFSRL LAWCFLLALS PQAPGSRGAE AVWTAYLNVS WRVPHTGVNR
TVWELSEEGV YGQDSPLEPV AGVLVPPDGP GALNACNPHT NFTVPTVWGS TVQVSWLALI
QRGGGCTFAD KIHLAYERGA SGAVIFNFPG TRNEVIPMSH PGAVDIVAIM IGNLKGTKIL
QSIQRGIQVT MVIEVGKKHG PWVNHYSIFF VSVSFFIITA ATVGYFIFYS ARRLRNARAQ
SRKQRQLKAD AKKAIGRLQL RTLKQGDKEI GPDGDSCAVC IELYKPNDLV RILTCNHIFH
KTCVDPWLLE HRTCPMCKCD ILKALGIEVD VEDGSVSLQV PVSNEISNSA SSHEEDNRSE
TASSGYASVQ GTDEPPLEEH VQSTNESLQL VNHEANSVAV DVIPHVDNPT FEEDETPNQE
TAVREIKS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
82	178	Domain	PA domain	IPR003137	PF02225
117	153	Homologous_superfamily	PA domain superfamily	IPR046450	SSF52025
234	323	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
275	318	Domain	Zinc finger, RING-type	IPR001841	PF13639
277	318	Domain	Zinc finger, RING-type	IPR001841	PS50089
277	317	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0001818	negative regulation of cytokine production	Biological Process	IEA	GO_REF:0000107
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0031647	regulation of protein stability	Biological Process	IMP	PMID:25635054
GO:0061462	protein localization to lysosome	Biological Process	IC	PMID:25635054
GO:1904352	positive regulation of protein catabolic process in the vacuole	Biological Process	IC	PMID:25635054
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005770	late endosome	Cellular Component	IBA	GO_REF:0000033
GO:0005783	endoplasmic reticulum	Cellular Component	IBA	GO_REF:0000033
GO:0005794	Golgi apparatus	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-5690196
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0012505	endomembrane system	Cellular Component	IEA	GO_REF:0000044
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


O15511	ARPC5	Yes	Yes	No	No	—	No	E3-specific
P31146	COR1A	Yes	Yes	No	No	—	No	E3-specific
P16070	CD44	Yes	No	No	No	—	No	E3-specific
P52565	GDIR1	Yes	Yes	No	No	—	No	E3-specific
P52566	GDIR2	Yes	Yes	No	No	—	No	E3-specific
Q01151	CD83	Yes	Yes	No	No	—	No	E3-specific
P29965	CD40L	Yes	Yes	No	No	—	No	E3-specific

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