OTU7A

Details:

UniProt Entry: Q8TE49
Gene: OTUD7A
Class: RING
Family: RING7
Protein length: 926
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 2l2d

Protein Sequence ▾

>Q8TE49
MVSSVLPNPT SAECWAALLH DPMTLDMDAV LSDFVRSTGA EPGLARDLLE GKNWDLTAAL
SDYEQLRQVH TANLPHVFNE GRGPKQPERE PQPGHKVERP CLQRQDDIAQ EKRLSRGISH
ASSAIVSLAR SHVASECNNE QFPLEMPIYT FQLPDLSVYS EDFRSFIERD LIEQATMVAL
EQAGRLNWWS TVCTSCKRLL PLATTGDGNC LLHAASLGMW GFHDRDLVLR KALYTMMRTG
AEREALKRRW RWQQTQQNKE EEWEREWTEL LKLASSEPRT HFSKNGGTGG GVDNSEDPVY
ESLEEFHVFV LAHILRRPIV VVADTMLRDS GGEAFAPIPF GGIYLPLEVP PNRCHCSPLV
LAYDQAHFSA LVSMEQRDQQ REQAVIPLTD SEHKLLPLHF AVDPGKDWEW GKDDNDNARL
AHLILSLEAK LNLLHSYMNV TWIRIPSETR APLAQPESPT ASAGEDVQSL ADSLDSDRDS
VCSNSNSNNG KNGKDKEKEK QRKEKDKTRA DSVANKLGSF SKTLGIKLKK NMGGLGGLVH
GKMGRANSAN GKNGDSAERG KEKKAKSRKG SKEESGASAS TSPSEKTTPS PTDKAAGASP
AEKGGGPRGD AWKYSTDVKL SLNILRAAMQ GERKFIFAGL LLTSHRHQFH EEMIGYYLTS
AQERFSAEQE QRRRDAATAA AAAAAAAAAT AKRPPRRPET EGVPVPERAS PGPPTQLVLK
LKERPSPGPA AGRAARAAAG GTASPGGGAR RASASGPVPG RSPPAPARQS VIHVQASGAR
DEACAPAVGA LRPCATYPQQ NRSLSSQSYS PARAAALRTV NTVESLARAV PGALPGAAGT
AGAAEHKSQT YTNGFGALRD GLEFADADAP TARSNGECGR GGPGPVQRRC QRENCAFYGR
AETEHYCSYC YREELRRRRE ARGARP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
199	374	Domain	OTU domain	IPR003323	PS50802
205	368	Domain	OTU domain	IPR003323	PF02338
884	919	Domain	Zinc finger, A20-type	IPR002653	PS51036
887	912	Domain	Zinc finger, A20-type	IPR002653	SM00259
889	912	Domain	Zinc finger, A20-type	IPR002653	PF01754

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006508	proteolysis	Biological Process	IEA	GO_REF:0000043
GO:0035871	protein K11-linked deubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0016579	protein deubiquitination	Biological Process	TAS	Reactome:R-HSA-5688426
GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8865182
GO:0004843	cysteine-type deubiquitinase activity	Molecular Function	IEA	GO_REF:0000117
GO:0008233	peptidase activity	Molecular Function	IEA	GO_REF:0000043
GO:0008234	cysteine-type peptidase activity	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016787	hydrolase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:35512704
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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