CHD5

Details:

UniProt Entry: Q8TDI0
Gene: CHD5
Class: RING
Family: RING10
Protein length: 1954
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 6guu

Protein Sequence ▾

>Q8TDI0
MRGPVGTEEE LPRLFAEEME NEDEMSEEED GGLEAFDDFF PVEPVSLPKK KKPKKLKENK
CKGKRKKKEG SNDELSENEE DLEEKSESEG SDYSPNKKKK KKLKDKKEKK AKRKKKDEDE
DDNDDGCLKE PKSSGQLMAE WGLDDVDYLF SEEDYHTLTN YKAFSQFLRP LIAKKNPKIP
MSKMMTVLGA KWREFSANNP FKGSSAAAAA AAVAAAVETV TISPPLAVSP PQVPQPVPIR
KAKTKEGKGP GVRKKIKGSK DGKKKGKGKK TAGLKFRFGG ISNKRKKGSS SEEDEREESD
FDSASIHSAS VRSECSAALG KKSKRRRKKK RIDDGDGYET DHQDYCEVCQ QGGEIILCDT
CPRAYHLVCL DPELEKAPEG KWSCPHCEKE GIQWEPKDDD DEEEEGGCEE EEDDHMEFCR
VCKDGGELLC CDACPSSYHL HCLNPPLPEI PNGEWLCPRC TCPPLKGKVQ RILHWRWTEP
PAPFMVGLPG PDVEPSLPPP KPLEGIPERE FFVKWAGLSY WHCSWVKELQ LELYHTVMYR
NYQRKNDMDE PPPFDYGSGD EDGKSEKRKN KDPLYAKMEE RFYRYGIKPE WMMIHRILNH
SFDKKGDVHY LIKWKDLPYD QCTWEIDDID IPYYDNLKQA YWGHRELMLG EDTRLPKRLL
KKGKKLRDDK QEKPPDTPIV DPTVKFDKQP WYIDSTGGTL HPYQLEGLNW LRFSWAQGTD
TILADEMGLG KTVQTIVFLY SLYKEGHSKG PYLVSAPLST IINWEREFEM WAPDFYVVTY
TGDKESRSVI RENEFSFEDN AIRSGKKVFR MKKEVQIKFH VLLTSYELIT IDQAILGSIE
WACLVVDEAH RLKNNQSKFF RVLNSYKIDY KLLLTGTPLQ NNLEELFHLL NFLTPERFNN
LEGFLEEFAD ISKEDQIKKL HDLLGPHMLR RLKADVFKNM PAKTELIVRV ELSQMQKKYY
KFILTRNFEA LNSKGGGNQV SLLNIMMDLK KCCNHPYLFP VAAVEAPVLP NGSYDGSSLV
KSSGKLMLLQ KMLKKLRDEG HRVLIFSQMT KMLDLLEDFL EYEGYKYERI DGGITGGLRQ
EAIDRFNAPG AQQFCFLLST RAGGLGINLA TADTVIIYDS DWNPHNDIQA FSRAHRIGQN
KKVMIYRFVT RASVEERITQ VAKRKMMLTH LVVRPGLGSK SGSMTKQELD DILKFGTEEL
FKDDVEGMMS QGQRPVTPIP DVQSSKGGNL AASAKKKHGS TPPGDNKDVE DSSVIHYDDA
AISKLLDRNQ DATDDTELQN MNEYLSSFKV AQYVVREEDG VEEVEREIIK QEENVDPDYW
EKLLRHHYEQ QQEDLARNLG KGKRIRKQVN YNDASQEDQE WQDELSDNQS EYSIGSEDED
EDFEERPEGQ SGRRQSRRQL KSDRDKPLPP LLARVGGNIE VLGFNARQRK AFLNAIMRWG
MPPQDAFNSH WLVRDLRGKS EKEFRAYVSL FMRHLCEPGA DGAETFADGV PREGLSRQHV
LTRIGVMSLV RKKVQEFEHV NGKYSTPDLI PEGPEGKKSG EVISSDPNTP VPASPAHLLP
APLGLPDKME AQLGYMDEKD PGAQKPRQPL EVQALPAALD RVESEDKHES PASKERAREE
RPEETEKAPP SPEQLPREEV LPEKEKILDK LELSLIHSRG DSSELRPDDT KAEEKEPIET
QQNGDKEEDD EGKKEDKKGK FKFMFNIADG GFTELHTLWQ NEERAAVSSG KIYDIWHRRH
DYWLLAGIVT HGYARWQDIQ NDPRYMILNE PFKSEVHKGN YLEMKNKFLA RRFKLLEQAL
VIEEQLRRAA YLNMTQDPNH PAMALNARLA EVECLAESHQ HLSKESLAGN KPANAVLHKV
LNQLEELLSD MKADVTRLPS MLSRIPPVAA RLQMSERSIL SRLTNRAGDP TIQQGAFGSS
QMYSNNFGPN FRGPGPGGIV NYNQMPLGPY VTDI

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
150	200	Domain	CHD, N-terminal	IPR012958	PF08073
316	389	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
335	393	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
343	390	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
345	388	Domain	Zinc finger, PHD-type	IPR001965	SM00249
345	389	Domain	Zinc finger, PHD-finger	IPR019787	PF00628
346	387	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
409	468	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
416	463	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
418	461	Domain	Zinc finger, PHD-type	IPR001965	SM00249
418	462	Domain	Zinc finger, PHD-finger	IPR019787	PF00628
431	552	Homologous_superfamily	Chromo-like domain superfamily	IPR016197	SSF54160
466	546	Domain	Chromo/chromo shadow domain	IPR000953	SM00298
497	554	Domain	Chromo/chromo shadow domain	IPR000953	PS50013
572	643	Homologous_superfamily	Chromo-like domain superfamily	IPR016197	SSF54160
590	646	Domain	Chromo/chromo shadow domain	IPR000953	SM00298
592	625	Domain	Chromo/chromo shadow domain	IPR000953	PS50013
593	631	Domain	Chromo domain	IPR023780	PF00385
673	931	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
696	908	Domain	Helicase superfamily 1/2, ATP-binding domain	IPR014001	SM00487
696	940	Homologous_superfamily	SNF2-like, N-terminal domain superfamily	IPR038718	G3DSA:3.40.50.10810
700	931	Domain	Chromodomain-helicase-DNA-binding protein 5, DEAH-box helicase domain	IPR028727	cd18057
712	896	Domain	Helicase superfamily 1/2, ATP-binding domain	IPR014001	PS51192
719	998	Domain	SNF2, N-terminal	IPR000330	PF00176
842	851	Conserved_site	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site	IPR002464	PS00690
933	1202	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
941	1169	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	G3DSA:3.40.50.300
1026	1138	Domain	Helicase, C-terminal	IPR001650	PF00271
1028	1193	Domain	Helicase, C-terminal	IPR001650	PS51194
1054	1138	Domain	Helicase, C-terminal	IPR001650	SM00490
1295	1359	Domain	Domain of unknown function DUF1087	IPR009463	SM01147
1302	1358	Domain	Domain of unknown function DUF1087	IPR009463	PF06465
1372	1531	Domain	CHD subfamily II, SANT-like domain	IPR009462	SM01146
1390	1528	Domain	CHD subfamily II, SANT-like domain	IPR009462	PF06461
1733	1878	Domain	CHD, C-terminal 2	IPR012957	PF08074

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0006338	chromatin remodeling	Biological Process	IEA	GO_REF:0000117
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IMP	PMID:23948251
GO:0007283	spermatogenesis	Biological Process	IEA	GO_REF:0000043
GO:0007399	nervous system development	Biological Process	IEA	GO_REF:0000043
GO:0008285	negative regulation of cell population proliferation	Biological Process	ISS	GO_REF:0000024
GO:0021895	cerebral cortex neuron differentiation	Biological Process	ISS	GO_REF:0000024
GO:0030154	cell differentiation	Biological Process	IEA	GO_REF:0000043
GO:0035092	sperm DNA condensation	Biological Process	ISS	GO_REF:0000024
GO:1901798	positive regulation of signal transduction by p53 class mediator	Biological Process	ISS	GO_REF:0000024
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0000785	chromatin	Cellular Component	IBA	GO_REF:0000033
GO:0000792	heterochromatin	Cellular Component	ISS	GO_REF:0000024
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0016020	membrane	Cellular Component	HDA	PMID:19946888
GO:0016607	nuclear speck	Cellular Component	IDA	GO_REF:0000052
GO:0016581	NuRD complex	Cellular Component	ISS	GO_REF:0000024
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0004386	helicase activity	Molecular Function	IEA	GO_REF:0000043
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016787	hydrolase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0003682	chromatin binding	Molecular Function	IBA	GO_REF:0000033
GO:0016887	ATP hydrolysis activity	Molecular Function	IBA	GO_REF:0000033
GO:0042393	histone binding	Molecular Function	IBA	GO_REF:0000033
GO:0061628	histone H3K27me3 reader activity	Molecular Function	IDA	PMID:23948251
GO:0140658	ATP-dependent chromatin remodeler activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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