DTX3L

>Q8TDB6
MASHLRPPSP LLVRVYKSGP RVRRKLESYF QSSKSSGGGE CTVSTQEHEA PGTFRVEFSE
RAAKERVLKK GEHQILVDEK PVPIFLVPTE NSIKKNTRPQ ISSLTQSQAE TPSGDMHQHE
GHIPNAVDSC LQKIFLTVTA DLNCNLFSKE QRAYITTLCP SIRKMEGHDG IEKVCGDFQD
IERIHQFLSE QFLESEQKQQ FSPSMTERKP LSQQERDSCI SPSEPETKAE QKSNYFEVPL
PYFEYFKYIC PDKINSIEKR FGVNIEIQES SPNMVCLDFT SSRSGDLEAA RESFASEFQK
NTEPLKQECV SLADSKQANK FKQELNHQFT KLLIKEKGGE LTLLGTQDDI SAAKQKISEA
FVKIPVKLFA ANYMMNVIEV DSAHYKLLET ELLQEISEIE KRYDICSKVS EKGQKTCILF
ESKDRQVDLS VHAYASFIDA FQHASCQLMR EVLLLKSLGK ERKHLHQTKF ADDFRKRHPN
VHFVLNQESM TLTGLPNHLA KAKQYVLKGG GMSSLAGKKL KEGHETPMDI DSDDSKAASP
PLKGSVSSEA SELDKKEKGI CVICMDTISN KKVLPKCKHE FCAPCINKAM SYKPICPTCQ
TSYGIQKGNQ PEGSMVFTVS RDSLPGYESF GTIVITYSMK AGIQTEEHPN PGKRYPGIQR
TAYLPDNKEG RKVLKLLYRA FDQKLIFTVG YSRVLGVSDV ITWNDIHHKT SRFGGPEMYG
YPDPSYLKRV KEELKAKGIE

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
20	83	Homologous_superfamily	Nucleotide-binding alpha-beta plait domain superfamily	IPR012677	G3DSA:3.30.70.330
36	740	Family	Deltex family	IPR039398	PTHR12622
543	610	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
560	600	Domain	DTX3L, RING-HC finger	IPR042843	cd16712
561	600	Domain	Zinc finger, RING-type	IPR001841	PS50089
561	599	Domain	Zinc finger, RING-type	IPR001841	SM00184
577	586	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
607	739	Domain	Deltex, C-terminal	IPR039396	PF18102
608	738	Domain	Deltex, C-terminal	IPR039396	cd09633
611	740	Homologous_superfamily	Deltex, C-terminal domain superfamily	IPR039399	G3DSA:3.30.390.130

GO term	Name	Ontology	Evidence	Reference
GO:0000077	DNA damage checkpoint signaling	Biological Process	IMP	PMID:28525742
GO:0002230	positive regulation of defense response to virus by host	Biological Process	IGI	PMID:26479788
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006302	double-strand break repair	Biological Process	IMP	PMID:23230272
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:26479788
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0007219	Notch signaling pathway	Biological Process	IEA	GO_REF:0000002
GO:0008333	endosome to lysosome transport	Biological Process	IMP	PMID:24790097
GO:0015031	protein transport	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0032092	positive regulation of protein binding	Biological Process	IMP	PMID:26479788
GO:0035563	positive regulation of chromatin binding	Biological Process	IGI	PMID:26479788
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000043
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IGI	PMID:26479788
GO:0051444	negative regulation of ubiquitin-protein transferase activity	Biological Process	IMP	PMID:24790097
GO:0051607	defense response to virus	Biological Process	IEA	GO_REF:0000043
GO:0051865	protein autoubiquitination	Biological Process	IMP	PMID:24790097
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:26479788
GO:0140861	DNA repair-dependent chromatin remodeling	Biological Process	IMP	PMID:19818714
GO:1900182	positive regulation of protein localization to nucleus	Biological Process	IGI	PMID:26479788
GO:1902966	positive regulation of protein localization to early endosome	Biological Process	IMP	PMID:24790097
GO:2000646	positive regulation of receptor catabolic process	Biological Process	IMP	PMID:24790097
GO:0005634	nucleus	Cellular Component	IDA	PMID:26479788
GO:0005769	early endosome	Cellular Component	IDA	PMID:24790097
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000043
GO:0005765	lysosomal membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000043
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0031901	early endosome membrane	Cellular Component	IEA	GO_REF:0000044
GO:0032991	protein-containing complex	Cellular Component	IDA	PMID:24790097
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:19818714
GO:0004857	enzyme inhibitor activity	Molecular Function	IMP	PMID:24790097
GO:0005515	protein binding	Molecular Function	IPI	PMID:16809771
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019899	enzyme binding	Molecular Function	IPI	PMID:28525742
GO:0042393	histone binding	Molecular Function	IDA	PMID:19818714
GO:0044389	ubiquitin-like protein ligase binding	Molecular Function	IPI	PMID:24790097
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0097677	STAT family protein binding	Molecular Function	IPI	PMID:26479788
GO:0140768	protein ADP-ribosyltransferase-substrate adaptor activity	Molecular Function	IDA	PMID:28525742
GO:0140852	histone ubiquitin ligase activity	Molecular Function	IMP	PMID:26479788
GO:0141000	histone H4K91 ubiquitin ligase activity	Molecular Function	IDA	PMID:19818714

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q8TDB6	DTX3L	Yes	No	No	No	—	No	E3-specific
P06899	H2B1J	Yes	Yes	No	No	—	No	E3-specific