MARH1

Details:

UniProt Entry: Q8TCQ1
Gene: MARCHF1
Class: RING
Family: RING2
Protein length: 289
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q8TCQ1
MLGWCEAIAR NPHRIPNNTR TPEISGDLAD ASQTSTLNEK SPGRSASRSS NISKASSPTT
GTAPRSQSRL SVCPSTQDIC RICHCEGDEE SPLITPCRCT GTLRFVHQSC LHQWIKSSDT
RCCELCKYDF IMETKLKPLR KWEKLQMTTS ERRKIFCSVT FHVIAITCVV WSLYVLIDRT
AEEIKQGNDN GVLEWPFWTK LVVVAIGFTG GLVFMYVQCK VYVQLWRRLK AYNRVIFVQN
CPDTAKKLEK NFSCNVNTDI KDAVVVPVPQ TGANSLPSAE GGPPEVVSV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
65	141	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
72	133	Domain	Zinc finger, RING-CH-type	IPR011016	PS51292
79	127	Domain	Zinc finger, RING-CH-type	IPR011016	SM00744
80	127	Domain	Zinc finger, RING-type	IPR001841	PS50089
80	126	Domain	Zinc finger, RING-CH-type	IPR011016	PF12906

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0002495	antigen processing and presentation of peptide antigen via MHC class II	Biological Process	IBA	GO_REF:0000033
GO:0006955	immune response	Biological Process	IBA	GO_REF:0000033
GO:0000139	Golgi membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000043
GO:0005765	lysosomal membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000043
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000043
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0030659	cytoplasmic vesicle membrane	Cellular Component	IEA	GO_REF:0000044
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0031901	early endosome membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005783	endoplasmic reticulum	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0031902	late endosome membrane	Cellular Component	IBA	GO_REF:0000033
GO:0005789	endoplasmic reticulum membrane	Cellular Component	ISS	GO_REF:0000024
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0032588	trans-Golgi network membrane	Cellular Component	ISS	GO_REF:0000024
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0042287	MHC protein binding	Molecular Function	IBA	GO_REF:0000033
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P49327	FAS	Yes	Yes	No	No	—	No	Cluster-specific
P02786	TFR1	Yes	Yes	No	No	—	No	Cluster-specific
P33076	C2TA	Yes	Yes	No	No	—	No	Cluster-specific
P42081	CD86	Yes	Yes	No	No	—	No	Cluster-specific
P01911	DRB1	Yes	Yes	No	No	—	No	Cluster-specific
Q30154	DRB5	Yes	Yes	No	No	—	No	Cluster-specific
P01730	CD4	Yes	Yes	No	No	—	No	Cluster-specific
P13762	DRB4	Yes	Yes	No	No	—	No	Cluster-specific
P79483	DRB3	Yes	Yes	No	No	—	No	Cluster-specific
P01903	DRA	Yes	Yes	No	No	—	No	Cluster-specific

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