SHKB1

Details:

UniProt Entry: Q8TBC3
Gene: SHKBP1
Class: Other E3 Components
Family: Adaptor
Protein length: 707
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8TBC3
MAAAATAAEG VPSRGPPGEV IHLNVGGKRF STSRQTLTWI PDSFFSSLLS GRISTLKDET
GAIFIDRDPT VFAPILNFLR TKELDPRGVH GSSLLHEAQF YGLTPLVRRL QLREELDRSS
CGNVLFNGYL PPPVFPVKRR NRHSLVGPQQ LGGRPAPVRR SNTMPPNLGN AGLLGRMLDE
KTPPSPSGQP EEPGMVRLVC GHHNWIAVAY TQFLVCYRLK EASGWQLVFS SPRLDWPIER
LALTARVHGG ALGEHDKMVA AATGSEILLW ALQAEGGGSE IGVFHLGVPV EALFFVGNQL
IATSHTGRIG VWNAVTKHWQ VQEVQPITSY DAAGSFLLLG CNNGSIYYVD VQKFPLRMKD
NDLLVSELYR DPAEDGVTAL SVYLTPKTSD SGNWIEIAYG TSSGGVRVIV QHPETVGSGP
QLFQTFTVHR SPVTKIMLSE KHLISVCADN NHVRTWSVTR FRGMISTQPG STPLASFKIL
ALESADGHGG CSAGNDIGPY GERDDQQVFI QKVVPSASQL FVRLSSTGQR VCSVRSVDGS
PTTAFTVLEC EGSRRLGSRP RRYLLTGQAN GSLAMWDLTT AMDGLGQAPA GGLTEQELME
QLEHCELAPP APSAPSWGCL PSPSPRISLT SLHSASSNTS LSGHRGSPSP PQAEARRRGG
GSFVERCQEL VRSGPDLRRP PTPAPWPSSG LGTPLTPPKM KLNETSF

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
18	120	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
19	88	Domain	BTB/POZ domain	IPR000210	PS50097
19	113	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
19	118	Domain	BTB/POZ domain	IPR000210	SM00225
21	106	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214
222	580	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
255	587	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
277	313	Repeat	WD40 repeat	IPR001680	SM00320
419	457	Repeat	WD40 repeat	IPR001680	SM00320
527	577	Repeat	WD40 repeat	IPR001680	SM00320

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:21145461
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:32296183

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