LNX1

Details:

UniProt Entry: Q8TBB1
Gene: LNX1
Class: RING
Family: RING9
Protein length: 728
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 3b76, 5h7r, 5h7s

Protein Sequence ▾

>Q8TBB1
MNQPESANDP EPLCAVCGQA HSLEENHFYS YPEEVDDDLI CHICLQALLD PLDTPCGHTY
CTLCLTNFLV EKDFCPMDRK PLVLQHCKKS SILVNKLLNK LLVTCPFREH CTQVLQRCDL
EHHFQTSCKG ASHYGLTKDR KRRSQDGCPD GCASLTATAP SPEVSAAATI SLMTDEPGLD
NPAYVSSAED GQPAISPVDS GRSNRTRARP FERSTIRSRS FKKINRALSV LRRTKSGSAV
ANHADQGREN SENTTAPEVF PRLYHLIPDG EITSIKINRV DPSESLSIRL VGGSETPLVH
IIIQHIYRDG VIARDGRLLP GDIILKVNGM DISNVPHNYA VRLLRQPCQV LWLTVMREQK
FRSRNNGQAP DAYRPRDDSF HVILNKSSPE EQLGIKLVRK VDEPGVFIFN VLDGGVAYRH
GQLEENDRVL AINGHDLRYG SPESAAHLIQ ASERRVHLVV SRQVRQRSPD IFQEAGWNSN
GSWSPGPGER SNTPKPLHPT ITCHEKVVNI QKDPGESLGM TVAGGASHRE WDLPIYVISV
EPGGVISRDG RIKTGDILLN VDGVELTEVS RSEAVALLKR TSSSIVLKAL EVKEYEPQED
CSSPAALDSN HNMAPPSDWS PSWVMWLELP RCLYNCKDIV LRRNTAGSLG FCIVGGYEEY
NGNKPFFIKS IVEGTPAYND GRIRCGDILL AVNGRSTSGM IHACLARLLK ELKGRITLTI
VSWPGTFL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
11	138	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
41	79	Domain	Zinc finger, RING-type	IPR001841	PS50089
41	78	Domain	Zinc finger, RING-type	IPR001841	SM00184
56	65	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
259	360	Homologous_superfamily	PDZ superfamily	IPR036034	SSF50156
264	372	Homologous_superfamily	PDZ superfamily	IPR036034	G3DSA:2.30.42.10
274	359	Domain	PDZ domain	IPR001478	PS50106
276	356	Domain	PDZ domain	IPR001478	PF00595
284	359	Domain	PDZ domain	IPR001478	SM00228
373	463	Homologous_superfamily	PDZ superfamily	IPR036034	G3DSA:2.30.42.10
375	465	Homologous_superfamily	PDZ superfamily	IPR036034	SSF50156
381	464	Domain	PDZ domain	IPR001478	PS50106
382	460	Domain	PDZ domain	IPR001478	PF00595
391	464	Domain	PDZ domain	IPR001478	SM00228
482	590	Homologous_superfamily	PDZ superfamily	IPR036034	SSF50156
500	596	Homologous_superfamily	PDZ superfamily	IPR036034	G3DSA:2.30.42.10
507	593	Domain	PDZ domain	IPR001478	PS50106
508	588	Domain	PDZ domain	IPR001478	PF00595
516	593	Domain	PDZ domain	IPR001478	SM00228
613	725	Homologous_superfamily	PDZ superfamily	IPR036034	SSF50156
633	724	Homologous_superfamily	PDZ superfamily	IPR036034	G3DSA:2.30.42.10
638	724	Domain	PDZ domain	IPR001478	PS50106
639	720	Domain	PDZ domain	IPR001478	PF00595
647	724	Domain	PDZ domain	IPR001478	SM00228

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0007399	nervous system development	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0060074	synapse maturation	Biological Process	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0098686	hippocampal mossy fiber to CA3 synapse	Cellular Component	IEA	GO_REF:0000107
GO:0098794	postsynapse	Cellular Component	IEA	GO_REF:0000107
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:16002321
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0030165	PDZ domain binding	Molecular Function	IEA	GO_REF:0000120
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
O60828	PQBP1	Yes	Yes	No	No	—	No	E3-specific
O76021	RL1D1	Yes	Yes	No	No	—	No	E3-specific
P56750	CLD17	Yes	Yes	No	No	—	No	E3-specific
P48546	GIPR	Yes	Yes	No	No	—	No	E3-specific
P41595	5HT2B	Yes	Yes	No	No	—	No	E3-specific
Q96BR9	ZBT8A	Yes	Yes	Yes	Yes	29892012, 16189514	EBI-755482	E3-specific
Q96KB5	TOPK	Yes	Yes	No	No	—	No	Cluster-specific
P22459	KCNA4	Yes	Yes	No	No	—	No	E3-specific
Q05586	NMDZ1	Yes	Yes	No	No	—	No	E3-specific
Q9UKL4	CXD2	Yes	No	No	No	—	No	Cluster-specific
P01732	CD8A	Yes	Yes	No	No	—	No	E3-specific

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