COP1

Details:

UniProt Entry: Q8NHY2
Gene: COP1
Class: RING
Family: RING9
Protein length: 731
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 5hqg, 5igq

Protein Sequence ▾

>Q8NHY2
MSGSRQAGSG SAGTSPGSSA ASSVTSASSS LSSSPSPPSV AVSAAALVSG GVAQAAGSGG
LGGPVRPVLV APAVSGSGGG AVSTGLSRHS CAARPSAGVG GSSSSLGSGS RKRPLLAPLC
NGLINSYEDK SNDFVCPICF DMIEEAYMTK CGHSFCYKCI HQSLEDNNRC PKCNYVVDNI
DHLYPNFLVN ELILKQKQRF EEKRFKLDHS VSSTNGHRWQ IFQDWLGTDQ DNLDLANVNL
MLELLVQKKK QLEAESHAAQ LQILMEFLKV ARRNKREQLE QIQKELSVLE EDIKRVEEMS
GLYSPVSEDS TVPQFEAPSP SHSSIIDSTE YSQPPGFSGS SQTKKQPWYN STLASRRKRL
TAHFEDLEQC YFSTRMSRIS DDSRTASQLD EFQECLSKFT RYNSVRPLAT LSYASDLYNG
SSIVSSIEFD RDCDYFAIAG VTKKIKVYEY DTVIQDAVDI HYPENEMTCN SKISCISWSS
YHKNLLASSD YEGTVILWDG FTGQRSKVYQ EHEKRCWSVD FNLMDPKLLA SGSDDAKVKL
WSTNLDNSVA SIEAKANVCC VKFSPSSRYH LAFGCADHCV HYYDLRNTKQ PIMVFKGHRK
AVSYAKFVSG EEIVSASTDS QLKLWNVGKP YCLRSFKGHI NEKNFVGLAS NGDYIACGSE
NNSLYLYYKG LSKTLLTFKF DTVKSVLDKD RKEDDTNEFV SAVCWRALPD GESNVLIAAN
SQGTIKVLEL V

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
13	731	Family	E3 ubiquitin-protein ligase COP1	IPR042755	PTHR44080
122	219	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
136	173	Domain	Zinc finger, RING-type	IPR001841	SM00184
136	174	Domain	Zinc finger, RING-type	IPR001841	PS50089
151	160	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
391	731	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
410	449	Repeat	WD40 repeat	IPR001680	SM00320
421	727	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
460	499	Repeat	WD40 repeat	IPR001680	SM00320
470	499	Repeat	WD40 repeat	IPR001680	PF00400
502	542	Repeat	WD40 repeat	IPR001680	SM00320
504	542	Repeat	WD40 repeat	IPR001680	PF00400
509	551	Repeat	WD40 repeat	IPR001680	PS50082
545	584	Repeat	WD40 repeat	IPR001680	SM00320
557	584	Repeat	WD40 repeat	IPR001680	PF00400
588	626	Repeat	WD40 repeat	IPR001680	SM00320
590	626	Repeat	WD40 repeat	IPR001680	PF00400
595	635	Repeat	WD40 repeat	IPR001680	PS50082
613	627	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
629	668	Repeat	WD40 repeat	IPR001680	SM00320
632	667	Repeat	WD40 repeat	IPR001680	PF00400

Enzyme–Substrate Interactions ▾

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P50991	TCPD	Yes	Yes	No	No	—	No	E3-specific
P03956	MMP1	Yes	Yes	No	No	—	No	E3-specific
Q6UUV9	CRTC1	Yes	No	No	No	—	No	E3-specific
O00399	DCTN6	Yes	No	No	No	—	No	E3-specific
Q13085	ACACA	Yes	Yes	No	No	—	No	E3-specific
O00763	ACACB	Yes	Yes	No	No	—	No	E3-specific
P50549	ETV1	Yes	Yes	No	No	25117710, 21572435, 28514442	EBI-15926602	E3-specific
Q53ET0	CRTC2	Yes	Yes	No	No	—	No	E3-specific
Q8NHY2	COP1	Yes	Yes	No	No	—	No	E3-specific
P41161	ETV5	Yes	Yes	No	No	25117710, 28514442, 35140242	EBI-29000238	E3-specific
P21589	5NTD	Yes	No	No	No	—	No	E3-specific

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