>Q8NHM5 MAGPQMGGSA EDHPPRKRHA AEKQKKKTVI YTKCFEFESA TQRPIDRQRY DENEDLSDVE EIVSVRGFSL EEKLRSQLYQ GDFVHAMEGK DFNYEYVQRE ALRVPLIFRE KDGLGIKMPD PDFTVRDVKL LVGSRRLVDV MDVNTQKGTE MSMSQFVRYY ETPEAQRDKL YNVISLEFSH TKLEHLVKRP TVVDLVDWVD NMWPQHLKEK QTEATNAIAE MKYPKVKKYC LMSVKGCFTD FHIDFGGTSV WYHVFRGGKI FWLIPPTLHN LALYEEWVLS GKQSDIFLGD RVERCQRIEL KQGYTFFIPS GWIHAVYTPV DSLVFGGNIL HSFNVPMQLR IYEIEDRTRV QPKFRYPFYY EMCWYVLERY VYCVTQRSHL TQEYQRESML IDAPRKPSID GFSSDSWLEM EEEACDQQPQ EEEEKDEEGE GRDRAPKPPT DGSTSPTSTP SEDQEALGKK PKAPALRFLK RTLSNESEES VKSTTLAVDY PKTPTGSPAT EVSAKWTHLT EFELKGLKAL VEKLESLPEN KKCVPEGIED PQALLEGVKN VLKEHADDDP SLAITGVPVV TWPKKTPKNR AVGRPKGKLG PASAVKLAAN RTTAGARRRR TRCRKCEACL RTECGECHFC KDMKKFGGPG RMKQSCIMRQ CIAPVLPHTA VCLVCGEAGK EDTVEEEEGK FNLMLMECSI CNEIIHPGCL KIKESEGVVN DELPNCWECP KCNHAGKTGK QKRGPGFKYA SNLPGSLLKE QKMNRDNKEG QEPAKRRSEC EEAPRRRSDE HSKKVPPDGL LRRKSDDVHL RKKRKYEKPQ ELSGRKRASS LQTSPGSSSH LSPRPPLGSS LSPWWRSSLT YFQQQLKPGK EDKLFRKKRR SWKNAEDRMA LANKPLRRFK QEPEDELPEA PPKTRESDHS RSSSPTAGPS TEGAEGPEEK KKVKMRRKRR LPNKELSREL SKELNHEIQR TENSLANENQ QPIKSEPESE GEEPKRPPGI CERPHRFSKG LNGTPRELRH QLGPSLRSPP RVISRPPPSV SPPKCIQMER HVIRPPPISP PPDSLPLDDG AAHVMHREVW MAVFSYLSHQ DLCVCMRVCR TWNRWCCDKR LWTRIDLNHC KSITPLMLSG IIRRQPVSLD LSWTNISKKQ LSWLINRLPG LRDLVLSGCS WIAVSALCSS SCPLLRTLDV QWVEGLKDAQ MRDLLSPPTD NRPGQMDNRS KLRNIVELRL AGLDITDASL RLIIRHMPLL SKLHLSYCNH VTDQSINLLT AVGTTTRDSL TEINLSDCNK VTDQCLSFFK RCGNICHIDL RYCKQVTKEG CEQFIAEMSV SVQFGQVEEK LLQKLS
The same domains may appear in multiple rows, following InterPro convention.
| Start | End | Type | Name | InterPro | Source |
|---|---|---|---|---|---|
| 178 | 346 | Domain | JmjC domain | IPR003347 | PS51184 |
| 178 | 346 | Domain | JmjC domain | IPR003347 | SM00558 |
| 334 | 372 | Domain | Jumonji, helical domain | IPR041070 | PF17811 |
| 606 | 652 | Domain | Zinc finger, CXXC-type | IPR002857 | PS51058 |
| 607 | 651 | Domain | Zinc finger, CXXC-type | IPR002857 | PF02008 |
| 647 | 723 | Homologous_superfamily | Zinc finger, RING/FYVE/PHD-type | IPR013083 | G3DSA:3.30.40.10 |
| 654 | 732 | Homologous_superfamily | Zinc finger, FYVE/PHD-type | IPR011011 | SSF57903 |
| 656 | 722 | Domain | Zinc finger, PHD-finger | IPR019787 | PF16866 |
| 659 | 725 | Domain | Zinc finger, PHD-finger | IPR019787 | PS50016 |
| 661 | 723 | Domain | Zinc finger, PHD-type | IPR001965 | SM00249 |
| 1054 | 1103 | Domain | F-box domain | IPR001810 | PF00646 |
| 1062 | 1327 | Homologous_superfamily | Leucine-rich repeat domain superfamily | IPR032675 | G3DSA:3.80.10.10 |
| 1148 | 1170 | Repeat | Leucine-rich repeat, cysteine-containing subtype | IPR006553 | SM00367 |
| 1172 | 1197 | Repeat | Leucine-rich repeat, cysteine-containing subtype | IPR006553 | SM00367 |
| 1212 | 1236 | Repeat | Leucine-rich repeat, cysteine-containing subtype | IPR006553 | SM00367 |
| 1237 | 1262 | Repeat | Leucine-rich repeat, cysteine-containing subtype | IPR006553 | SM00367 |
| 1267 | 1291 | Repeat | Leucine-rich repeat, cysteine-containing subtype | IPR006553 | SM00367 |
| 1292 | 1317 | Repeat | Leucine-rich repeat, cysteine-containing subtype | IPR006553 | SM00367 |
| GO term | Name | Ontology | Evidence | Reference |
|---|---|---|---|---|
| GO:0006338 | chromatin remodeling | Biological Process | IEA | GO_REF:0000108 |
| GO:0006325 | chromatin organization | Biological Process | IEA | GO_REF:0000043 |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | Biological Process | IEA | GO_REF:0000107 |
| GO:0030307 | positive regulation of cell growth | Biological Process | IEA | GO_REF:0000107 |
| GO:1902459 | positive regulation of stem cell population maintenance | Biological Process | IEA | GO_REF:0000107 |
| GO:0006357 | regulation of transcription by RNA polymerase II | Biological Process | IBA | GO_REF:0000033 |
| GO:0007283 | spermatogenesis | Biological Process | ISS | GO_REF:0000024 |
| GO:0021555 | midbrain-hindbrain boundary morphogenesis | Biological Process | ISS | GO_REF:0000024 |
| GO:0021592 | fourth ventricle development | Biological Process | ISS | GO_REF:0000024 |
| GO:0021670 | lateral ventricle development | Biological Process | ISS | GO_REF:0000024 |
| GO:0021678 | third ventricle development | Biological Process | ISS | GO_REF:0000024 |
| GO:0021993 | initiation of neural tube closure | Biological Process | ISS | GO_REF:0000024 |
| GO:0030900 | forebrain development | Biological Process | ISS | GO_REF:0000024 |
| GO:0030901 | midbrain development | Biological Process | ISS | GO_REF:0000024 |
| GO:0030902 | hindbrain development | Biological Process | ISS | GO_REF:0000024 |
| GO:0043524 | negative regulation of neuron apoptotic process | Biological Process | ISS | GO_REF:0000024 |
| GO:0048596 | embryonic camera-type eye morphogenesis | Biological Process | ISS | GO_REF:0000024 |
| GO:2000178 | negative regulation of neural precursor cell proliferation | Biological Process | ISS | GO_REF:0000024 |
| GO:0005654 | nucleoplasm | Cellular Component | IDA | GO_REF:0000052 |
| GO:0005634 | nucleus | Cellular Component | IEA | GO_REF:0000120 |
| GO:0005694 | chromosome | Cellular Component | IEA | GO_REF:0000120 |
| GO:0005730 | nucleolus | Cellular Component | IEA | GO_REF:0000044 |
| GO:0031519 | PcG protein complex | Cellular Component | IDA | PMID:16943429 |
| GO:0003677 | DNA binding | Molecular Function | IEA | GO_REF:0000043 |
| GO:0008270 | zinc ion binding | Molecular Function | IEA | GO_REF:0000120 |
| GO:0045322 | unmethylated CpG binding | Molecular Function | IEA | GO_REF:0000117 |
| GO:0046872 | metal ion binding | Molecular Function | IEA | GO_REF:0000043 |
| GO:0051864 | histone H3K36 demethylase activity | Molecular Function | IEA | GO_REF:0000117 |
| GO:0016491 | oxidoreductase activity | Molecular Function | IEA | GO_REF:0000043 |
| GO:0051213 | dioxygenase activity | Molecular Function | IEA | GO_REF:0000043 |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | Molecular Function | IEA | GO_REF:0000107 |
| GO:0003712 | transcription coregulator activity | Molecular Function | IBA | GO_REF:0000033 |
| GO:0003723 | RNA binding | Molecular Function | IEA | GO_REF:0000043 |
| GO:0005515 | protein binding | Molecular Function | IPI | PMID:16943429 |
| GO:0019843 | rRNA binding | Molecular Function | IEA | GO_REF:0000043 |
| GO:0032452 | histone demethylase activity | Molecular Function | IBA | GO_REF:0000033 |
| GO:0140680 | histone H3K36me/H3K36me2 demethylase activity | Molecular Function | IEA | GO_REF:0000120 |
| Substrate | Name | Known ESI (UbiBrowser) |
Known ESI (UbiNet) |
PPI (IntAct direct) PSI-MI score ≥ 0.5 |
PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs |
PubMed Ref. | IntAct Ref. | Substrate Specificity |
|---|---|---|---|---|---|---|---|---|
| P01100 | FOS | Yes | Yes | No | No | 35140242 | EBI-29015727 | E3-specific |
| Type | ChEMBL Compound ID | Source | pChEMBL | PDB Compound ID | PDB Codes | SMILES |
|---|---|---|---|---|---|---|
| E3 Binder | CHEMBL3786952 | ChEMBL | 7.0 | 6EP | — | Cc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 |
| E3 Binder | CHEMBL4283409 | ChEMBL | 7.0 | — | — | Clc1cccc(-n2cnc(-c3cc4[nH]nnc4cn3)c2)c1 |
| E3 Binder | CHEMBL4290020 | ChEMBL | 7.0 | — | — | CC(=O)OCn1nnc(-c2ccnc(-c3cn(Cc4ccccc4Cl)cn3)c2)n1 |
| E3 Binder | CHEMBL4289480 | ChEMBL | 6.0 | — | — | CC(=O)OCn1nnc(-c2ccnc(-c3ncn(Cc4ccccc4Cl)c3-c3ccc(F)cc3)c2)n1 |
| E3 Binder | CHEMBL4286299 | ChEMBL | 6.0 | — | — | CC(C)(C)C(=O)OCn1nnc(-c2ccnc(-c3cn(Cc4ccccc4Cl)cn3)c2)n1 |
| E3 Binder | CHEMBL4285770 | ChEMBL | 6.0 | — | — | CC(C)(C)C(=O)OCn1nnc(-c2ccnc(-c3ncn(Cc4ccccc4Cl)c3-c3ccc(F)cc3)c2)n1 |
| E3 Binder | CHEMBL4281270 | ChEMBL | 7.0 | — | — | CC(C)(C)c1ccc(CCn2cnc(-c3cc(-c4nn[nH]c4C(F)(F)F)ccn3)c2)cc1 |
| E3 Binder | CHEMBL4293028 | ChEMBL | 7.0 | — | — | CC(C)C(c1ccccc1)n1cnc(-c2cc(-c3nn[nH]c3C(F)(F)F)ccn2)c1 |
| E3 Binder | CHEMBL4281159 | ChEMBL | 6.0 | — | — | CC(C)COc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 |
| E3 Binder | CHEMBL4283306 | ChEMBL | 7.0 | — | — | CC(C)COc1ccccc1Cn1cnc(-c2cc(-c3nn[nH]n3)ccn2)c1 |
| E3 Binder | CHEMBL4291030 | ChEMBL | 7.0 | — | — | CC(Cc1ccccc1)n1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 |
| E3 Binder | CHEMBL4287296 | ChEMBL | 6.0 | — | — | CCCCOc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 |
| E3 Binder | CHEMBL4287794 | ChEMBL | 7.0 | — | — | CCCc1cc(O)n(-c2cc(C(=O)O)ccn2)n1 |
| E3 Binder | CHEMBL3787669 | ChEMBL | 7.0 | — | — | CCN(CCN(C)C)C(=O)CNCc1cc(C(=O)O)ccn1 |
| E3 Binder | CHEMBL4277960 | ChEMBL | 7.0 | — | — | CCOc1cc(Cl)ccc1-c1c(-c2cc(C(=O)O)ccn2)ncn1C |
| E3 Binder | CHEMBL4285443 | ChEMBL | 7.0 | — | — | CCOc1ccc(-c2c(-c3cc(C(=O)O)ccn3)ncn2C)cc1 |
| E3 Binder | CHEMBL4276861 | ChEMBL | 7.0 | — | — | CCOc1ccccc1CCn1cnc(-c2cc(-c3nn[nH]c3C(F)(F)F)ccn2)c1 |
| E3 Binder | CHEMBL4288034 | ChEMBL | 7.0 | — | — | CCc1ccc(-c2c(-c3cc(C(=O)O)ccn3)ncn2C)cc1 |
| E3 Binder | CHEMBL4287332 | ChEMBL | 7.0 | — | — | CCc1ccc(CCn2cnc(-c3cc(-c4nn[nH]c4C(F)(F)F)ccn3)c2)cc1 |
| E3 Binder | CHEMBL4227237 | ChEMBL | 6.0 | — | — | CCc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)cc1 |
| E3 Binder | CHEMBL4279284 | ChEMBL | 7.0 | — | — | CN(C)CCOCCn1cnc(-c2cc(C(=O)O)ccn2)c1 |
| E3 Binder | CHEMBL4288025 | ChEMBL | 7.0 | — | — | CN(CCn1cnc(-c2cc(C(=O)O)ccn2)c1)CC1CC1 |
| E3 Binder | CHEMBL4287989 | ChEMBL | 6.0 | — | — | CN1CCC(Cn2cnc(-c3cc(C(=O)O)ccn3)c2)CC1 |
| E3 Binder | CHEMBL4291702 | ChEMBL | 7.0 | — | — | CN1CCC(n2cnc(-c3cc(C(=O)O)ccn3)c2)CC1 |
| E3 Binder | CHEMBL4288884 | ChEMBL | 6.0 | — | — | COc1cc(C)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 |
| E3 Binder | CHEMBL3786803 | ChEMBL | 7.0 | — | — | COc1ccc(-c2c(-c3cc(C(=O)O)ccn3)ncn2C)cc1 |
| E3 Binder | CHEMBL4277565 | ChEMBL | 7.0 | — | — | COc1ccc2c(c1)C(Cn1cnc(-c3cc(-c4nn[nH]c4C(F)(F)F)ccn3)c1)CCC2 |
| E3 Binder | CHEMBL4277381 | ChEMBL | 7.0 | — | — | COc1ccc2c(c1)CCCC2Cn1cnc(-c2cc(-c3nn[nH]c3C(F)(F)F)ccn2)c1 |
| E3 Binder | CHEMBL4292396 | ChEMBL | 7.0 | — | — | COc1cccc2c1C(Cn1cnc(-c3cc(-c4nn[nH]c4C(F)(F)F)ccn3)c1)CCC2 |
| E3 Binder | CHEMBL4294417 | ChEMBL | 7.0 | — | — | COc1cccc2c1CCCC2Cn1cnc(-c2cc(-c3nn[nH]c3C(F)(F)F)ccn2)c1 |
| E3 Binder | CHEMBL4286275 | ChEMBL | 7.0 | — | — | Cc1cc(O)n(-c2cc(C(=O)O)ccn2)n1 |
| E3 Binder | CHEMBL4288406 | ChEMBL | 7.0 | — | — | Cc1ccc(-c2c(-c3cc(C(=O)O)ccn3)ncn2C)cc1 |
| E3 Binder | CHEMBL4292111 | ChEMBL | 7.0 | — | — | Cc1ccc(-c2c(-c3cc(C(=O)O)ccn3)ncn2C)cc1O |
| E3 Binder | CHEMBL4289921 | ChEMBL | 6.0 | — | — | Cc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)c(C)c1 |
| E3 Binder | CHEMBL4283926 | ChEMBL | 6.0 | — | — | Cc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)c(Cl)c1 |
| E3 Binder | CHEMBL4228087 | ChEMBL | 6.0 | — | — | Cc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)cc1 |
| E3 Binder | CHEMBL4286133 | ChEMBL | 6.0 | — | — | Cc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)cc1Cl |
| E3 Binder | CHEMBL4279372 | ChEMBL | 7.0 | — | — | Cc1ccc(OCC2CC2)c(-c2c(-c3cc(C(=O)O)ccn3)ncn2C)c1 |
| E3 Binder | CHEMBL4291852 | ChEMBL | 7.0 | — | — | Cc1ccc2c(c1)C(Cn1cnc(-c3cc(-c4nn[nH]c4C(F)(F)F)ccn3)c1)CCC2 |
| E3 Binder | CHEMBL4290800 | ChEMBL | 6.0 | — | — | Cc1ccc2c(c1)CCCC2Cn1cnc(-c2cc(-c3nn[nH]c3C(F)(F)F)ccn2)c1 |
| E3 Binder | CHEMBL4293636 | ChEMBL | 7.0 | — | — | Cc1nn(-c2cc(C(=O)O)ccn2)c(O)c1-c1ccccc1 |
| E3 Binder | CHEMBL4292883 | ChEMBL | 7.0 | — | — | Cc1nn(-c2cc(C(=O)O)ccn2)c(O)c1C |
| E3 Binder | CHEMBL4294250 | ChEMBL | 7.0 | — | — | Clc1cc(Cl)cc(-n2cnc(-c3cc4[nH]nnc4cn3)c2)c1 |
| E3 Binder | CHEMBL4288414 | ChEMBL | 7.0 | — | — | Clc1ccc(-c2c(-c3cc(-c4nn[nH]n4)ccn3)ncn2CCc2ccccc2Cl)cc1 |
| E3 Binder | CHEMBL4281254 | ChEMBL | 7.0 | — | — | Cn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 |
| E3 Binder | CHEMBL4277370 | ChEMBL | 6.0 | — | — | Cn1cnc(-c2cc(-c3nn[nH]c3F)ccn2)c1-c1ccc(F)cc1OCC1CC1 |
| E3 Binder | CHEMBL4294755 | ChEMBL | 7.0 | — | — | Cn1cnc(-c2cc(-c3nn[nH]n3)ccn2)c1-c1ccc(F)c(C(=O)Nc2ccccc2)c1 |
| E3 Binder | CHEMBL4294432 | ChEMBL | 7.0 | — | — | Cn1cnc(-c2cc(-c3nn[nH]n3)ccn2)c1-c1ccc(F)c(OCC(F)(F)F)c1 |
| E3 Binder | CHEMBL4286418 | ChEMBL | 7.0 | — | — | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(-n2cccn2)cc1 |
| E3 Binder | CHEMBL4286983 | ChEMBL | 7.0 | — | — | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(C(F)(F)F)cc1 |
| E3 Binder | CHEMBL4284869 | ChEMBL | 7.0 | — | — | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(C2CC2)cc1 |
| E3 Binder | CHEMBL4283146 | ChEMBL | 7.0 | — | — | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(Cl)c(C(F)(F)F)c1 |
| E3 Binder | CHEMBL4286705 | ChEMBL | 7.0 | — | — | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(Cl)c(Cl)c1 |
| E3 Binder | CHEMBL4288145 | ChEMBL | 7.0 | — | — | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(OC(F)(F)F)cc1 |
| E3 Binder | CHEMBL3787664 | ChEMBL | 7.0 | — | — | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(OCC2CC2)cc1 |
| E3 Binder | CHEMBL4293936 | ChEMBL | 7.0 | — | — | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1cccc(CO)c1 |
| E3 Binder | CHEMBL4278863 | ChEMBL | 7.0 | — | — | Cn1cnc(-c2cc(C(=O)O)ccn2)c1Br |
| E3 Binder | CHEMBL4286185 | ChEMBL | 7.0 | — | — | Cn1cnc(-c2cc3[nH]nnc3cn2)c1-c1ccc(F)cc1 |
| E3 Binder | CHEMBL4289929 | ChEMBL | 7.0 | — | — | Cn1cnc(-c2cc3[nH]nnc3cn2)c1-c1ccc(F)cc1OCC1CC1 |
| E3 Binder | CHEMBL4290631 | ChEMBL | 7.0 | — | — | Cn1ncc2ccc(COc3ccnn3-c3cc(C(=O)O)ccn3)cc21 |
| E3 Binder | CHEMBL4285921 | ChEMBL | 6.0 | — | — | Cn1nnc(-c2ccnc(-c3cn(Cc4ccccc4Cl)cn3)c2)n1 |
| E3 Binder | CHEMBL4279214 | ChEMBL | 7.0 | — | — | FC(F)(F)COc1ccccc1Cn1cnc(-c2cc(-c3nn[nH]c3C(F)(F)F)ccn2)c1 |
| E3 Binder | CHEMBL4287712 | ChEMBL | 7.0 | — | — | FC(F)(F)Cn1cnc(-c2cc3[nH]nnc3cn2)c1 |
| E3 Binder | CHEMBL4289252 | ChEMBL | 7.0 | — | — | FC(F)(F)c1[nH]nnc1-c1ccnc(-c2cn(CC3CCc4ccccc43)cn2)c1 |
| E3 Binder | CHEMBL4294747 | ChEMBL | 7.0 | — | — | FC(F)(F)c1[nH]nnc1-c1ccnc(-c2cn(CCc3cccc4ccccc34)cn2)c1 |
| E3 Binder | CHEMBL4285698 | ChEMBL | 7.0 | — | — | FC(F)(F)c1ccc(CCn2cnc(-c3cc(-c4nn[nH]c4C(F)(F)F)ccn3)c2)cc1 |
| E3 Binder | CHEMBL4278662 | ChEMBL | 7.0 | — | — | FC(F)(F)c1ccccc1CCn1cnc(-c2cc(-c3nn[nH]c3C(F)(F)F)ccn2)c1 |
| E3 Binder | CHEMBL4289127 | ChEMBL | 7.0 | — | — | Fc1c(Cn2cnc(-c3cc(-c4c[nH]nn4)ccn3)c2)cccc1OC(F)(F)F |
| E3 Binder | CHEMBL4290366 | ChEMBL | 7.0 | — | — | Fc1ccc(-c2c(-c3cc(-c4nn[nH]n4)ccn3)ncn2Cc2cccc(Cl)c2)c(OCC2CC2)c1 |
| E3 Binder | CHEMBL4287778 | ChEMBL | 7.0 | — | — | Fc1ccc2c(c1)C(Cn1cnc(-c3cc(-c4nn[nH]c4C(F)(F)F)ccn3)c1)CCC2 |
| E3 Binder | CHEMBL4286728 | ChEMBL | 7.0 | — | — | Fc1ccc2c(c1)CCCC2Cn1cnc(-c2cc(-c3nn[nH]c3C(F)(F)F)ccn2)c1 |
| E3 Binder | CHEMBL4289631 | ChEMBL | 7.0 | — | — | Fc1cccc(Cl)c1CCn1cnc(-c2cc(-c3nn[nH]c3C(F)(F)F)ccn2)c1 |
| E3 Binder | CHEMBL4286353 | ChEMBL | 7.0 | — | — | Fc1cccc2c1CCCC2Cn1cnc(-c2cc(-c3nn[nH]c3C(F)(F)F)ccn2)c1 |
| E3 Binder | CHEMBL4229271 | ChEMBL | 6.0 | — | — | N#Cc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)cc1 |
| E3 Binder | CHEMBL4286314 | ChEMBL | 7.0 | — | — | O=C(O)c1ccnc(-c2cn(C3CCNC3)cn2)c1 |
| E3 Binder | CHEMBL4286674 | ChEMBL | 7.0 | — | — | O=C(O)c1ccnc(-c2cn(CC3CCCN3)cn2)c1 |
| E3 Binder | CHEMBL4294777 | ChEMBL | 6.0 | — | — | O=C(O)c1ccnc(-c2cn(CCN3CCCC3)cn2)c1 |
| E3 Binder | CHEMBL4293359 | ChEMBL | 7.0 | — | — | O=C(O)c1ccnc(-c2cn(CCN3CCc4cc(F)ccc43)cn2)c1 |
| E3 Binder | CHEMBL4290028 | ChEMBL | 7.0 | — | — | O=C(O)c1ccnc(-c2cn(CCn3cccn3)cn2)c1 |
| E3 Binder | CHEMBL4284987 | ChEMBL | 6.0 | — | — | O=C(O)c1ccnc(-n2ccc(Cc3ccccc3)n2)c1 |
| E3 Binder | CHEMBL4281922 | ChEMBL | 7.0 | — | — | O=C(O)c1ccnc(-n2nc(Cc3cc(Cl)cc(Cl)c3)cc2O)c1 |
| E3 Binder | CHEMBL4285977 | ChEMBL | 6.0 | — | — | O=C(O)c1ccnc(-n2nccc2Cc2ccccc2)c1 |
| E3 Binder | CHEMBL4287317 | ChEMBL | 7.0 | — | — | O=C(O)c1ccnc(-n2nccc2O)c1 |
| E3 Binder | CHEMBL4287561 | ChEMBL | 6.0 | — | — | O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)c(OCC3CC3)c2)c1 |
| E3 Binder | CHEMBL4292430 | ChEMBL | 6.0 | — | — | O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)cc2OCC(F)(F)F)c1 |
| E3 Binder | CHEMBL4225515 | ChEMBL | 6.0 | — | — | O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)cc2OCC2CC2)c1 |
| E3 Binder | CHEMBL4289695 | ChEMBL | 6.0 | — | — | O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)cc2OCc2ccc(F)cc2)c1 |
| E3 Binder | CHEMBL4227526 | ChEMBL | 7.0 | — | — | O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)cc2OCc2ccccc2)c1 |
| E3 Binder | CHEMBL4290069 | ChEMBL | 6.0 | — | — | O=C(O)c1ccnc(-n2nccc2OCc2ccc(F)cc2OCc2ccc(F)cc2)c1 |
| E3 Binder | CHEMBL4285840 | ChEMBL | 7.0 | — | — | O=C(O)c1ccnc(-n2nccc2OCc2ccc3cn[nH]c3c2)c1 |
| E3 Binder | CHEMBL4283417 | ChEMBL | 7.0 | — | — | c1cc(-c2nn[nH]n2)cc(-c2cn(CCN3CCCC3)cn2)n1 |
| E3 Binder | CHEMBL4292175 | ChEMBL | 7.0 | — | — | c1ccc(-c2ccccc2CCn2cnc(-c3cc(-c4c[nH]nn4)ccn3)c2)cc1 |