ZNRF2

Details:

UniProt Entry: Q8NHG8
Gene: ZNRF2
Class: RING
Family: RING4
Protein length: 242
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q8NHG8
MGAKQSGPAA ANGRTRAYSG SDLPSSSSGG ANGTAGGGGG ARAAAAGRFP AQVPSAHQPS
ASGGAAAAAA APAAPAAPRS RSLGGAVGSV ASGARAAQSP FSIPNSSSGP YGSQDSVHSS
PEDGGGGRDR PVGGSPGGPR LVIGSLPAHL SPHMFGGFKC PVCSKFVSSD EMDLHLVMCL
TKPRITYNED VLSKDAGECA ICLEELQQGD TIARLPCLCI YHKGCIDEWF EVNRSCPEHP
SD

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
181	240	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
198	237	Domain	Zinc finger, RING-type	IPR001841	PF13639
199	239	Domain	Zinc finger, RING-type	IPR001841	PS50089
199	239	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0030007	intracellular potassium ion homeostasis	Biological Process	IDA	PMID:10636900
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0070936	protein K48-linked ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0160177	positive regulation of autophagosome-lysosome fusion	Biological Process	IGI	PMID:38360932
GO:0001650	fibrillar center	Cellular Component	IDA	GO_REF:0000052
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000120
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0042734	presynaptic membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005765	lysosomal membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-983140
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000043
GO:0010008	endosome membrane	Cellular Component	IEA	GO_REF:0000044
GO:0030659	cytoplasmic vesicle membrane	Cellular Component	IDA	PMID:22797923
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000043
GO:0032991	protein-containing complex	Cellular Component	IDA	PMID:22797923
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q8NHG8	ZNRF2	Yes	No	No	No	—	No	E3-specific

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