TRI58

Details:

UniProt Entry: Q8NG06
Gene: TRIM58
Class: RING
Family: RING5
Protein length: 486
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q8NG06
MAWAPPGERL REDARCPVCL DFLQEPVSVD CGHSFCLRCI SEFCEKSDGA QGGVYACPQC
RGPFRPSGFR PNRQLAGLVE SVRRLGLGAG PGARRCARHG EDLSRFCEED EAALCWVCDA
GPEHRTHRTA PLQEAAGSYQ VKLQMALELM RKELEDALTQ EANVGKKTVI WKEKVEMQRQ
RFRLEFEKHR GFLAQEEQRQ LRRLEAEERA TLQRLRESKS RLVQQSKALK ELADELQERC
QRPALGLLEG VRGVLSRSKA VTRLEAENIP MELKTACCIP GRRELLRKFQ VDVKLDPATA
HPSLLLTADL RSVQDGEPWR DVPNNPERFD TWPCILGLQS FSSGRHYWEV LVGEGAEWGL
GVCQDTLPRK GETTPSPENG VWALWLLKGN EYMVLASPSV PLLQLESPRC IGIFLDYEAG
EISFYNVTDG SYIYTFNQLF SGLLRPYFFI CDATPLILPP TTIAGSGNWA SRDHLDPASD
VRDDHL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
7	87	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
13	63	Domain	E3 ubiquitin-protein ligase TRIM58, RING finger, HC subclass	IPR042699	cd16606
16	61	Domain	Zinc finger, RING-type	IPR001841	PS50089
16	60	Domain	Zinc finger, RING-type	IPR001841	SM00184
31	40	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
91	132	Domain	B-box-type zinc finger	IPR000315	PS50119
91	132	Domain	B-box-type zinc finger	IPR000315	SM00336
94	132	Domain	B-box-type zinc finger	IPR000315	PF00643
273	463	Domain	B30.2/SPRY domain	IPR001870	PS50188
283	460	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
284	466	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
289	306	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
290	342	Domain	SPRY-associated	IPR006574	SM00589
292	459	Domain	E3 ubiquitin-protein ligase TRIM58, PRY/SPRY domain	IPR035787	cd15816
293	341	Domain	SPRY-associated	IPR006574	PF13765
306	323	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
328	352	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
343	462	Domain	SPRY domain	IPR003877	SM00449
345	450	Domain	SPRY domain	IPR003877	PF00622
358	371	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
402	426	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
432	450	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0010468	regulation of gene expression	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0051865	protein autoubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0061931	positive regulation of erythrocyte enucleation	Biological Process	IEA	GO_REF:0000107
GO:1902838	regulation of nuclear migration along microtubule	Biological Process	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0045504	dynein heavy chain binding	Molecular Function	IEA	GO_REF:0000107
GO:0045505	dynein intermediate chain binding	Molecular Function	IEA	GO_REF:0000107
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


O43237	DC1L2	Yes	Yes	No	No	—	No	E3-specific
O14576	DC1I1	Yes	Yes	No	No	—	No	E3-specific

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
O43237	DC1L2	Yes	Yes	No	No	—	No	E3-specific
O14576	DC1I1	Yes	Yes	No	No	—	No	E3-specific