KBTB8

Details:

UniProt Entry: Q8NFY9
Gene: KBTBD8
Class: Other E3 Components
Family: Adaptor
Protein length: 601
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8NFY9
MAASADLSKS SPTPNGIPSS DPASDAMDPF HACSILKQLK TMYDEGQLTD IVVEVDHGKT
FSCHRNVLAA ISPYFRSMFT SGLTESTQKE VRIVGVEAES MDLVLNYAYT SRVILTEANV
QALFTAASIF QIPSIQDQCA KYMISHLDPQ NSIGVFIFAD HYGHQELGDR SKEYIRKKFL
CVTKEQEFLQ LTKDQLISIL DSDDLNVDRE EHVYESIIRW FEHEQNEREV HLPEIFAKCI
RFPLMEDTFI EKIPPQFAQA IAKSCVEKGP SNTNGCTQRL GMTASEMIIC FDAAHKHSGK
KQTVPCLDIV TGRVFKLCKP PNDLREVGIL VSPDNDIYIA GGYRPSSSEV SIDHKAENDF
WMYDHSTNRW LSKPSLLRAR IGCKLVYCCG KMYAIGGRVY EGDGRNSLKS VECYDSRENC
WTTVCAMPVA MEFHNAVEYK EKIYVLQGEF FLFYEPQKDY WGFLTPMTVP RIQGLAAVYK
DSIYYIAGTC GNHQRMFTVE AYDIELNKWT RKKDFPCDQS INPYLKLVLF QNKLHLFVRA
TQVTVEEHVF RTSRKNSLYQ YDDIADQWMK VYETPDRLWD LGRHFECAVA KLYPQCLQKV
L

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
15	573	Family	BTB-kelch protein	IPR017096	PIRSF037037
23	148	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
27	155	Domain	Kelch repeat and BTB domain-containing protein 8, BTB/POZ domain	IPR028764	cd18274
29	145	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
40	146	Domain	BTB/POZ domain	IPR000210	PF00651
49	117	Domain	BTB/POZ domain	IPR000210	PS50097
49	147	Domain	BTB/POZ domain	IPR000210	SM00225
152	254	Domain	BTB/Kelch-associated	IPR011705	SM00875
153	252	Domain	BTB/Kelch-associated	IPR011705	PF07707
274	599	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
298	580	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
331	376	Repeat	Kelch repeat type 1	IPR006652	PF01344
336	390	Repeat	Kelch repeat type 1	IPR006652	SM00612
379	424	Repeat	Kelch repeat type 1	IPR006652	PF01344
391	441	Repeat	Kelch repeat type 1	IPR006652	SM00612
476	514	Repeat	Kelch repeat type 1	IPR006652	PF01344
482	532	Repeat	Kelch repeat type 1	IPR006652	SM00612
549	582	Family	BTB-kelch protein	IPR017096	PIRSF037037

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006417	regulation of translation	Biological Process	IEA	GO_REF:0000043
GO:0006513	protein monoubiquitination	Biological Process	IDA	PMID:26399832
GO:0014029	neural crest formation	Biological Process	IEA	GO_REF:0000117
GO:0014032	neural crest cell development	Biological Process	IEA	GO_REF:0000120
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000120
GO:0005819	spindle	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952630
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:21145461
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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