FBX22

Details:

UniProt Entry: Q8NEZ5
Gene: FBXO22
Class: Other E3 Components
Family: Receptor
Protein length: 403
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8NEZ5
MEPVGCCGEC RGSSVDPRST FVLSNLAEVV ERVLTFLPAK ALLRVACVCR LWRECVRRVL
RTHRSVTWIS AGLAEAGHLE GHCLVRVVAE ELENVRILPH TVLYMADSET FISLEECRGH
KRARKRTSME TALALEKLFP KQCQVLGIVT PGIVVTPMGS GSNRPQEIEI GESGFALLFP
QIEGIKIQPF HFIKDPKNLT LERHQLTEVG LLDNPELRVV LVFGYNCCKV GASNYLQQVV
STFSDMNIIL AGGQVDNLSS LTSEKNPLDI DASGVVGLSF SGHRIQSATV LLNEDVSDEK
TAEAAMQRLK AANIPEHNTI GFMFACVGRG FQYYRAKGNV EADAFRKFFP SVPLFGFFGN
GEIGCDRIVT GNFILRKCNE VKDDDLFHSY TTIMALIHLG SSK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
28	68	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
28	59	Domain	F-box domain	IPR001810	PF00646
232	366	Domain	FIST, C-domain	IPR019494	SM01204
300	364	Domain	FIST, C-domain	IPR019494	PF10442

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0006913	nucleocytoplasmic transport	Biological Process	IEA	GO_REF:0000107
GO:0009267	cellular response to starvation	Biological Process	IEA	GO_REF:0000107
GO:0010830	regulation of myotube differentiation	Biological Process	IEA	GO_REF:0000107
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0048742	regulation of skeletal muscle fiber development	Biological Process	IEA	GO_REF:0000107
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0036211	protein modification process	Biological Process	TAS	PMID:10531035
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0030018	Z disc	Cellular Component	IEA	GO_REF:0000044
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	TAS	PMID:10531037
GO:0005515	protein binding	Molecular Function	IPI	PMID:21145461

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